ZRdb KZFP & Repeats
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Human_ZNF221

  • Protein
    Zinc finger protein 221
  • Length
    617
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    74.0 Mya
  • Time of Changing in binding specificity
    74.0 Mya
  • Uniprot_ID
    Q9UK13
  • NCBI_ID
    7638
Sequence:
MISPSLELLHSGLCKFPEVEGKMTTFKEAVTFKDVAVVFTEEELGLLDPAQRKLYRDVMLENFRNLLSVGNQPFHQDTFHFLGKEKFWKMKTTSQREGNSGGKIQIEMETVPEAGPHEEWSCQQIWEQIASDLTRSQNSIRNSSQFFKEGDVPCQIEARLSISHVQQKPYRCNECKQSFSDVSVFDLHQQSHSGEKSHTCGECGKSFCYSPALHIHQRVHMGEKCYKCDVCGKEFNQSSHLQTHQRVHTGEKPFKCGQCGKGFHSRSALNVHCKLHTGEKPYNCEECGKAFIHDSQLQEHQRIHTGEKPFKCDICGKSFRVRSRLNRHSMVHTGEKPFRCDTCGKNFRQRSALNSHSMVHIEEKPYKCEQCGKGFICRRDFCKHQMVHTGEKPYNCKECGKTFRWSSCLLNHQQVHSGQKSFKCEECGKGFYTNSRRSSHQRSHNGEKPYNCEECGKDYKRRLDLEFHQRVHTGERPYNCKECGKSFGWASCLLKHQRLHSGEKPFKCEECGKRFTQSSQLHSHQTCHTGEKLYKCEQCEKGYNSKFNLDMHQRVHGGERPYNCKECGKSFGWASCLLKHQRLHSGEKPLKSGVWEEIYSEFTASFTSVSLCGRKAI
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 30..100
2 C2h2 170..192
3 C2h2 198..220
4 C2h2 226..248
5 dec2h2 254..276
6 C2h2 282..304
7 C2h2 310..332
8 C2h2 338..360
9 C2h2 366..388
10 C2h2 394..416
11 C2h2 422..444
12 C2h2 450..472
13 C2h2 478..500
14 C2h2 506..528
15 C2h2 534..556
16 C2h2 562..584
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of DNA-templated transcription
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 AluSc8 8 **** 74.0 Highly correlated
2 AluYj4 7 **** 0.0 Weakly correlated
3 AluJb 4 n.s 74.0 Highly correlated
4 LTR10A 4 **** 28.9 Weakly correlated
5 LTR10F 3 **** 28.9 Weakly correlated
6 L1P3 3 ** 74.0 Highly correlated
7 SVA_F 2 *** 0.0 Weakly correlated
8 LTR24 2 **** 74.0 Highly correlated
9 FRAM 2 ** 74.0 Highly correlated
10 AluYm1 2 ** 19.6 Weakly correlated
11 AluYa8 2 **** 15.2 Weakly correlated
12 AluY 2 n.s 74.0 Highly correlated
13 HERV17-int 1 * 28.9 Weakly correlated
14 L1M4 1 n.s 99.0 Weakly correlated
15 L1MB8 1 n.s 99.0 Weakly correlated
16 L1P4 1 n.s 74.0 Highly correlated
17 L2a 1 n.s 99.0 Weakly correlated
18 LTR10B1 1 **** 28.9 Weakly correlated
19 AluSz 1 n.s 74.0 Highly correlated
20 MIRb 1 n.s 99.0 Weakly correlated
21 MLT1L 1 n.s 99.0 Weakly correlated
22 SVA_D 1 n.s 15.2 Weakly correlated
23 AluSp 1 n.s 74.0 Highly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 AluYj4 2 *** 0.0 Weakly correlated
2 L1P3 2 * 74.0 Highly correlated
3 L1P4 1 n.s 74.0 Highly correlated
4 AluSc8 1 n.s 74.0 Highly correlated
5 AluY 1 n.s 74.0 Highly correlated
6 AluYa8 1 **** 15.2 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP