ZRdb KZFP & Repeats
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Human_ZNF215

  • Protein
    Zinc finger protein 215
  • Length
    517
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    99.0 Mya
  • Uniprot_ID
    Q9UL58
  • NCBI_ID
    7762
Sequence:
MQPLSKLMAISKPRNLSLREQREVLRADMSWQQETNPVVETHDSEASRQKFRHFQYLKVSGPHEALSQLWELCLQWLRPEIHTKKQIIELLVLEQFLAILPEEVRTWVNLQHPNNSKDMVTLIEDVIEMLEDEDMPCKDSALQMGSIKEKMKAGSRTGKPQEPVTFKDVVVEFSKEEWGQLDSAVKNLYRNVMLENFRNLNSLRKAHLLSKPFESLKLESKKKRWIMEKEIPRKTIFDMKSISGEESSHGVIMTRLTESGHPSSDAWKGENWLYRNQKKWDINLPQEAFIPETIYTEEEDFECSENKKSFDINSVSSICAIQVGIPSRKGSPKCDKFKTYFKFNLDSVGKQHSEYEYGNDLSLSTDIRHQKSHTTMNSYECYQCGKAFCRSSSLIRHQIIHTGEKPYKCSECGRFFNRRTNLTKHQKLHAEAKACTSNKCGKAFSKSEDSNNPTLHFGNNFYQCVNCGKSFNRSSSLIRHQMIHTGEKPFKCKECSKAFNRSSNLVKHQKLHTRDKS
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 scan 48..126
2 KRAB 164..237
3 C2h2 379..401
4 C2h2 407..429
5 C2h2 462..484
6 C2h2 490..512
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity
3 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
4 Molecular Function metal ion binding
5 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
6 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 AluYj4 18 **** 0.0 Weakly correlated
2 L1P3 8 **** 74.0 Weakly correlated
3 AluSc8 8 ** 74.0 Weakly correlated
4 LTR8 7 **** 43.0 Weakly correlated
5 FRAM 6 **** 74.0 Weakly correlated
6 AluYa8 4 **** 15.2 Weakly correlated
7 AluJo 3 n.s 74.0 Weakly correlated
8 MER21B 3 ** 99.0 Highly correlated
9 AluY 3 n.s 74.0 Weakly correlated
10 AluJb 3 n.s 74.0 Weakly correlated
11 L1PA4 2 n.s 19.6 Weakly correlated
12 AluYh9 2 **** 15.2 Weakly correlated
13 L1PA10 2 n.s 74.0 Weakly correlated
14 SVA_C 2 ** 15.2 Weakly correlated
15 HUERS-P3b-int 2 ** 43.0 Weakly correlated
16 AluSp 2 n.s 74.0 Weakly correlated
17 LTR13 2 ** 19.6 Weakly correlated
18 MER21C 1 n.s 99.0 Highly correlated
19 L2 1 n.s 99.0 Highly correlated
20 L2a 1 n.s 99.0 Highly correlated
21 SVA_F 1 n.s 0.0 Weakly correlated
22 MIRb 1 n.s 99.0 Highly correlated
23 MLT1L 1 n.s 99.0 Highly correlated
24 MLT-int 1 ** 99.0 Highly correlated
25 MLT1A0 1 n.s 99.0 Highly correlated
26 L1PA5 1 n.s 19.6 Weakly correlated
27 L1PA2 1 n.s 15.2 Weakly correlated
28 L1P4 1 n.s 74.0 Weakly correlated
29 L1MEg 1 n.s 99.0 Highly correlated
30 L1MB8 1 n.s 99.0 Highly correlated
31 L1M3 1 n.s 99.0 Highly correlated
32 L1HS 1 n.s 8.6 Weakly correlated
33 AluYm1 1 n.s 19.6 Weakly correlated
34 AluYi6 1 *** 15.2 Weakly correlated
35 AluSz 1 n.s 74.0 Weakly correlated
36 AluSx3 1 n.s 74.0 Weakly correlated
37 AluSq 1 n.s 74.0 Weakly correlated
38 AluJr 1 n.s 74.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 HUERS-P3b-int 2 ** 43.0 Weakly correlated
2 AluY 1 n.s 74.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP