ZRdb KZFP & Repeats
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Human_ZNF211

  • Protein
    Zinc finger protein 211
  • Length
    564
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    94.0 Mya
  • Time of Changing in binding specificity
    94.0 Mya
  • Uniprot_ID
    Q13398
  • NCBI_ID
    10520
Sequence:
MLGFPPGRPQLPVQLRPQTRMATALRDPASGSVTFEDVAVYFSWEEWDLLDEAQKHLYFDVMLENFALTSSLGCWCGVEHEETPSEQRISGERVPQFRTSKEGSSSQNADSCEICCLVLRDILHLAEHQGTNCGQKLHTCGKQFYISANLQQHQRQHITEAPFRSYVDTASFTQSCIVHVSEKPFTCREIRKDFLANMRFLHQDATQTGEKPNNSNKCAVAFYSGKSHHNWGKCSKAFSHIDTLVQDQRILTREGLFECSKCGKACTRRCNLIQHQKVHSEERPYECNECGKFFTYYSSFIIHQRVHTGERPYACPECGKSFSQIYSLNSHRKVHTGERPYECGECGKSFSQRSNLMQHRRVHTGERPYECSECGKSFSQNFSLIYHQRVHTGERPHECNECGKSFSRSSSLIHHRRLHTGERPYECSKCGKSFKQSSSFSSHRKVHTGERPYVCGECGKSFSHSSNLKNHQRVHTGERPVECSECSKSFSCKSNLIKHLRVHTGERPYECSECGKSFSQSSSLIQHRRVHTGKRPYQCSQCGKSFGCKSVLIQHQRVHIGEKP
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 33..106
2 C2h2 131..157
3 C2h2 257..279
4 C2h2 285..307
5 C2h2 313..335
6 C2h2 341..363
7 C2h2 369..391
8 C2h2 397..419
9 C2h2 425..447
10 C2h2 453..475
11 C2h2 481..503
12 C2h2 509..531
13 C2h2 537..559
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 MER34A 114 **** 99.0 Moderately correlated
2 L1PB1 31 **** 74.0 Weakly correlated
3 AluJb 30 *** 74.0 Weakly correlated
4 AluY 28 ** 74.0 Weakly correlated
5 L1MCa 23 **** 99.0 Moderately correlated
6 AluSz 16 n.s 74.0 Weakly correlated
7 AluSx 15 n.s 74.0 Weakly correlated
8 L1ME1 15 ** 99.0 Moderately correlated
9 AluSq2 14 * 74.0 Weakly correlated
10 AluJr 13 n.s 74.0 Weakly correlated
11 AluSp 13 * 74.0 Weakly correlated
12 L1MB7 12 ** 99.0 Moderately correlated
13 L1M4 11 ** 99.0 Moderately correlated
14 L1MC1 11 *** 99.0 Moderately correlated
15 AluSx1 10 n.s 74.0 Weakly correlated
16 L1PB2 10 **** 74.0 Weakly correlated
17 L2c 10 n.s 99.0 Moderately correlated
18 L1MEc 9 * 99.0 Moderately correlated
19 MER34A1 9 **** 99.0 Moderately correlated
20 AluJo 8 n.s 74.0 Weakly correlated
21 AluSz6 8 n.s 74.0 Weakly correlated
22 LTR10A 8 **** 28.9 Weakly correlated
23 AluJr4 7 ** 74.0 Weakly correlated
24 L1PA16 7 n.s 74.0 Weakly correlated
25 L2a 7 n.s 99.0 Moderately correlated
26 MIR 6 n.s 99.0 Moderately correlated
27 AluSc 5 n.s 74.0 Weakly correlated
28 AluSc8 5 n.s 74.0 Weakly correlated
29 AluSg 5 n.s 74.0 Weakly correlated
30 L1M3 5 ** 99.0 Moderately correlated
31 L1MC4 5 n.s 99.0 Moderately correlated
32 L1MD 5 ** 99.0 Moderately correlated
33 L1MEf 5 n.s 99.0 Moderately correlated
34 L1MEg 5 n.s 99.0 Moderately correlated
35 L1PA13 5 n.s 74.0 Weakly correlated
36 L1PA15 5 n.s 74.0 Weakly correlated
37 L1PA2 5 n.s 15.2 Weakly correlated
38 L1PA5 5 n.s 19.6 Weakly correlated
39 L1PB3 5 ** 74.0 Weakly correlated
40 AluSq 4 n.s 74.0 Weakly correlated
41 HAL1 4 n.s 99.0 Moderately correlated
42 L1MA5A 4 ** 87.0 Weakly correlated
43 L1MB1 4 * 99.0 Moderately correlated
44 L1MB2 4 * 99.0 Moderately correlated
45 L1MB8 4 n.s 99.0 Moderately correlated
46 L1ME4b 4 n.s 99.0 Moderately correlated
47 L1P3 4 * 74.0 Weakly correlated
48 MIRb 4 n.s 99.0 Moderately correlated
49 AluSg4 3 * 74.0 Weakly correlated
50 AluSx3 3 n.s 74.0 Weakly correlated
51 ERV3-16A3_I-int 3 n.s 99.0 Moderately correlated
52 FLAM_A 3 ** 74.0 Weakly correlated
53 FLAM_C 3 n.s 74.0 Weakly correlated
54 L1MA8 3 n.s 87.0 Weakly correlated
55 L1MB3 3 n.s 99.0 Moderately correlated
56 L1MB5 3 n.s 99.0 Moderately correlated
57 L1MC 3 * 99.0 Moderately correlated
58 L1MC3 3 n.s 99.0 Moderately correlated
59 L1ME3G 3 n.s 99.0 Moderately correlated
60 L1P1 3 n.s 19.6 Weakly correlated
61 L1PA4 3 n.s 19.6 Weakly correlated
62 LTR29 3 **** 43.0 Weakly correlated
63 MER34C2 3 **** 74.0 Weakly correlated
64 MER50 3 ** 43.0 Weakly correlated
65 MLT1A0 3 n.s 99.0 Moderately correlated
66 AluYa5 2 * 15.2 Weakly correlated
67 HUERS-P1-int 2 ** 43.0 Weakly correlated
68 L1M1 2 n.s 74.0 Weakly correlated
69 L1M4a1 2 * 99.0 Moderately correlated
70 L1M5 2 n.s 99.0 Moderately correlated
71 L1MA6 2 n.s 87.0 Weakly correlated
72 L1MA9 2 n.s 99.0 Moderately correlated
73 L1MB4 2 n.s 99.0 Moderately correlated
74 L1MDa 2 n.s 99.0 Moderately correlated
75 L1PA11 2 n.s 74.0 Weakly correlated
76 L1PA7 2 n.s 74.0 Weakly correlated
77 L1PREC2 2 n.s 43.0 Weakly correlated
78 LTR10F 2 *** 28.9 Weakly correlated
79 LTR13 2 ** 19.6 Weakly correlated
80 MER34C_ 2 *** 87.0 Weakly correlated
81 MER39B 2 ** 74.0 Weakly correlated
82 MER50-int 2 ** 43.0 Weakly correlated
83 MIR3 2 n.s 99.0 Moderately correlated
84 MLT1F1 2 * 99.0 Moderately correlated
85 MLT2A2 2 * 74.0 Weakly correlated
86 MLT2D 2 * 99.0 Moderately correlated
87 AluSx4 1 n.s 74.0 Weakly correlated
88 AluYj4 1 * 0.0 Weakly correlated
89 AluYm1 1 n.s 19.6 Weakly correlated
90 FAM 1 * 87.0 Weakly correlated
91 FRAM 1 n.s 74.0 Weakly correlated
92 L1M4a2 1 n.s 99.0 Moderately correlated
93 L1M4b 1 n.s 99.0 Moderately correlated
94 L1M4c 1 n.s 99.0 Moderately correlated
95 L1MA1 1 n.s 74.0 Weakly correlated
96 L1MA10 1 n.s 99.0 Moderately correlated
97 L1MA2 1 n.s 74.0 Weakly correlated
98 L1MA3 1 n.s 74.0 Weakly correlated
99 L1MA4A 1 n.s 87.0 Weakly correlated
100 L1MA7 1 n.s 87.0 Weakly correlated
101 L1MC2 1 n.s 99.0 Moderately correlated
102 L1MCb 1 n.s 99.0 Moderately correlated
103 L1MD1 1 n.s 99.0 Moderately correlated
104 L1ME2 1 n.s 99.0 Moderately correlated
105 L1ME3D 1 n.s 99.0 Moderately correlated
106 L1ME3F 1 n.s 99.0 Moderately correlated
107 L1ME4a 1 n.s 99.0 Moderately correlated
108 L1MEi 1 n.s 99.0 Moderately correlated
109 L1P4 1 n.s 74.0 Weakly correlated
110 L1P4a 1 * 74.0 Weakly correlated
111 L1PA10 1 n.s 74.0 Weakly correlated
112 L1PA15-16 1 n.s 74.0 Weakly correlated
113 L1PA8A 1 n.s 74.0 Weakly correlated
114 L1PB 1 n.s 74.0 Weakly correlated
115 L2b 1 n.s 99.0 Moderately correlated
116 LTR47B2 1 *** 74.0 Weakly correlated
117 LTR9 1 * 43.0 Weakly correlated
118 MER11A 1 n.s 28.9 Weakly correlated
119 MER34 1 * 87.0 Weakly correlated
120 MER34B 1 ** 87.0 Weakly correlated
121 MER87 1 *** 43.0 Weakly correlated
122 MLT1G1 1 n.s 99.0 Moderately correlated
123 MLT1H2 1 n.s 99.0 Moderately correlated
124 MLT1L 1 n.s 99.0 Moderately correlated
125 MLT1N2 1 n.s 99.0 Moderately correlated
126 MLT2A1 1 n.s 74.0 Weakly correlated
127 MSTA-int 1 n.s 43.0 Weakly correlated
128 MSTB 1 n.s 43.0 Weakly correlated
129 MamRTE1 1 n.s 99.0 Moderately correlated
130 PABL_A-int 1 ** 74.0 Weakly correlated
131 THE1B 1 n.s 43.0 Weakly correlated
132 THE1B-int 1 n.s 43.0 Weakly correlated
133 THE1C 1 n.s 43.0 Weakly correlated
134 THE1D-int 1 n.s 28.9 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 MER34A 84 **** 99.0 Moderately correlated
2 L1PB1 18 **** 74.0 Weakly correlated
3 L1MCa 11 **** 99.0 Moderately correlated
4 MER34A1 7 **** 99.0 Moderately correlated
5 L1PB2 6 *** 74.0 Weakly correlated
6 L1M4 6 n.s 99.0 Moderately correlated
7 L1MC1 6 n.s 99.0 Moderately correlated
8 L1MEc 5 n.s 99.0 Moderately correlated
9 L1ME1 4 n.s 99.0 Moderately correlated
10 L1PA16 3 n.s 74.0 Weakly correlated
11 L1PB3 3 * 74.0 Weakly correlated
12 L1MB1 3 n.s 99.0 Moderately correlated
13 L1MB7 3 n.s 99.0 Moderately correlated
14 L2c 3 n.s 99.0 Moderately correlated
15 ERV3-16A3_I-int 2 n.s 99.0 Moderately correlated
16 L1MA6 2 n.s 87.0 Weakly correlated
17 L1MC4 2 n.s 99.0 Moderately correlated
18 L1MC3 2 n.s 99.0 Moderately correlated
19 L1MB2 2 n.s 99.0 Moderately correlated
20 AluJb 2 n.s 74.0 Weakly correlated
21 L1MD 2 n.s 99.0 Moderately correlated
22 AluJo 2 n.s 74.0 Weakly correlated
23 MER34C_ 2 *** 87.0 Weakly correlated
24 L1PA13 2 n.s 74.0 Weakly correlated
25 LTR29 2 *** 43.0 Weakly correlated
26 THE1D-int 1 n.s 28.9 Weakly correlated
27 L1M4c 1 n.s 99.0 Moderately correlated
28 L1MA9 1 n.s 99.0 Moderately correlated
29 L1ME2 1 n.s 99.0 Moderately correlated
30 L1MB4 1 n.s 99.0 Moderately correlated
31 L1ME4b 1 n.s 99.0 Moderately correlated
32 L2a 1 n.s 99.0 Moderately correlated
33 L1M1 1 n.s 74.0 Weakly correlated
34 MER34B 1 ** 87.0 Weakly correlated
35 AluY 1 n.s 74.0 Weakly correlated
36 L1PA4 1 n.s 19.6 Weakly correlated
37 L1MB8 1 n.s 99.0 Moderately correlated
38 L1PA15-16 1 n.s 74.0 Weakly correlated
39 AluSp 1 n.s 74.0 Weakly correlated
40 L1M3 1 n.s 99.0 Moderately correlated
41 L1MA1 1 n.s 74.0 Weakly correlated
42 L1MC 1 n.s 99.0 Moderately correlated
43 L1MEf 1 n.s 99.0 Moderately correlated
44 L1PA2 1 n.s 15.2 Weakly correlated
45 AluSx 1 n.s 74.0 Weakly correlated
46 L1MCb 1 n.s 99.0 Moderately correlated
47 THE1B 1 n.s 43.0 Weakly correlated
48 L1MA8 1 n.s 87.0 Weakly correlated
49 L1MC2 1 n.s 99.0 Moderately correlated
50 L1PA8A 1 n.s 74.0 Weakly correlated
51 L1PREC2 1 n.s 43.0 Weakly correlated
52 MER34 1 * 87.0 Weakly correlated
53 L1PA15 1 n.s 74.0 Weakly correlated
54 L1PA7 1 n.s 74.0 Weakly correlated
55 MER34C2 1 ** 74.0 Weakly correlated
56 MLT1G1 1 n.s 99.0 Moderately correlated
57 MLT2A1 1 n.s 74.0 Weakly correlated
58 L1MDa 1 n.s 99.0 Moderately correlated
59 L1ME3G 1 n.s 99.0 Moderately correlated
60 L1MEi 1 n.s 99.0 Moderately correlated
61 L1PA11 1 n.s 74.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP
1 L1PB1 74.0 Weakly correlated
2 L1PB2 74.0 Weakly correlated
3 MER34A 99.0 Moderately correlated
4 MER34A1 99.0 Moderately correlated