ZRdb KZFP & Repeats
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Human_ZNF20

  • Protein
    Zinc finger protein 20
  • Length
    532
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    87.0 Mya
  • Time of Changing in binding specificity
    43.0 Mya
  • Uniprot_ID
    P17024
  • NCBI_ID
    7568
Sequence:
MMFQDSVAFEDVAVSFTQEEWALLDPSQKNLYRDVMQETFKNLTSVGKTWKVQNIEDEYKNPRRNLSLMREKLCESKESHHCGESFNQIADDMLNRKTLPGITPCESSVCGEVGTGHSSLNTHIRADTGHKSSEYQEYGENPYRNKECKKAFSYLDSFQSHDKACTKEKPYDGKECTETFISHSCIQRHRVMHSGDGPYKCKFCGKAFYFLNLCLIHERIHTGVKPYKCKQCGKAFTRSTTLPVHERTHTGVNADECKECGNAFSFPSEIRRHKRSHTGEKPYECKQCGKVFISFSSIQYHKMTHTGEKPYECKQCGKAFRCGSHLQKHGRTHTGEKPYECRQCGKAFRCTSDLQRHEKTHTEDKPYGCKQCGKGFRCASQLQIHERTHSGEKPHECKECGKVFKYFSSLRIHERTHTGEKPHECKQCGKAFRYFSSLHIHERTHTGDKPYECKVCGKAFTCSSSIRYHERTHTGEKPYECKHCGKAFISNYIRYHERTHTGEKPYQCKQCGKAFIRASSCREHERTHTINR
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 7..78
2 C2h2 103..130
3 dec2h2 143..165
4 dec2h2 171..193
5 C2h2 199..221
6 C2h2 227..249
7 C2h2 255..277
8 C2h2 283..305
9 C2h2 311..333
10 C2h2 339..361
11 C2h2 367..389
12 C2h2 395..417
13 C2h2 423..445
14 C2h2 451..473
15 C2h2 479..500
16 C2h2 506..528
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function DNA-binding transcription repressor activity, RNA polymerase II-specific
4 Molecular Function metal ion binding
5 Molecular Function RNA polymerase II transcription regulatory region sequence-specific DNA binding
6 Biological Process negative regulation of transcription by RNA polymerase II
7 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 MER51A 43 **** 43.0 Highly correlated
2 MER51E 16 **** 43.0 Highly correlated
3 AluYj4 12 **** 0.0 Weakly correlated
4 L1P3 10 **** 74.0 Weakly correlated
5 AluSc8 8 ** 74.0 Weakly correlated
6 MER21B 5 **** 99.0 Weakly correlated
7 FRAM 5 **** 74.0 Weakly correlated
8 AluSp 4 n.s 74.0 Weakly correlated
9 AluYa8 4 **** 15.2 Weakly correlated
10 AluY 3 n.s 74.0 Weakly correlated
11 MER51B 3 **** 43.0 Highly correlated
12 AluJo 2 n.s 74.0 Weakly correlated
13 L1MC4 2 n.s 99.0 Weakly correlated
14 L2c 2 n.s 99.0 Weakly correlated
15 HUERS-P3b-int 2 *** 43.0 Highly correlated
16 AluYb8 2 ** 15.2 Weakly correlated
17 AluSx1 2 n.s 74.0 Weakly correlated
18 SVA_C 2 *** 15.2 Weakly correlated
19 MIRb 1 n.s 99.0 Weakly correlated
20 MLT1A1 1 n.s 87.0 Weakly correlated
21 LTR13 1 * 19.6 Weakly correlated
22 AluJb 1 n.s 74.0 Weakly correlated
23 L2b 1 n.s 99.0 Weakly correlated
24 SVA_F 1 * 0.0 Weakly correlated
25 L2 1 n.s 99.0 Weakly correlated
26 L1PA5 1 n.s 19.6 Weakly correlated
27 L1PA4 1 n.s 19.6 Weakly correlated
28 L1PA10 1 n.s 74.0 Weakly correlated
29 L1P4 1 n.s 74.0 Weakly correlated
30 L1MEg 1 n.s 99.0 Weakly correlated
31 L1MA8 1 n.s 87.0 Weakly correlated
32 L1M3 1 n.s 99.0 Weakly correlated
33 L1HS 1 n.s 8.6 Weakly correlated
34 AluYm1 1 n.s 19.6 Weakly correlated
35 AluYi6 1 *** 15.2 Weakly correlated
36 AluYh9 1 **** 15.2 Weakly correlated
37 AluSz 1 n.s 74.0 Weakly correlated
38 AluSq2 1 n.s 74.0 Weakly correlated
39 AluSq 1 n.s 74.0 Weakly correlated
40 AluSc5 1 n.s 74.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 AluYj4 5 **** 0.0 Weakly correlated
2 FRAM 4 *** 74.0 Weakly correlated
3 AluYa8 2 **** 15.2 Weakly correlated
4 HUERS-P3b-int 2 *** 43.0 Highly correlated
5 AluSc8 1 n.s 74.0 Weakly correlated
6 AluSq 1 n.s 74.0 Weakly correlated
7 MER51E 1 *** 43.0 Highly correlated
8 AluJb 1 n.s 74.0 Weakly correlated
9 AluJo 1 n.s 74.0 Weakly correlated
10 MER51A 1 * 43.0 Highly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP