ZRdb KZFP & Repeats
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Human_ZNF189

  • Protein
    Zinc finger protein 189
  • Length
    626
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    99.0 Mya
  • Uniprot_ID
    O75820
  • NCBI_ID
    7743
Sequence:
MASPSPPPESKGLLTFEDVAVFFTQEEWDYLDPAQRSLYKDVMMENYGNLVSLDVLNRDKDEEPTVKQEIEEIEEEVEPQGVIVTRIKSEIDQDPMGRETFELVGRLDKQRGIFLWEIPRESLTQEQRMFRENTNIIRKRPNSEEKCHKCEECGKGFVRKAHFIQHQRVHTGEKPFQCNECGKSFSRSSFVIEHQRIHTGERPYECNYCGKTFSVSSTLIRHQRIHTGERPYQCNQCKQSFSQRRSLVKHQRIHTGEKPHKCSDCGKAFSWKSHLIEHQRTHTGEKPYHCTKCKKSFSRNSLLVEHQRIHTGERPHKCGECGKAFRLSTYLIQHQKIHTGEKPFLCIECGKSFSRSSFLIEHQRIHTGERPYQCKECGKSFSQLCNLTRHQRIHTGDKPHKCEECGKAFSRSSGLIQHQRIHTREKTYPYNETKESFDPNCSLVIQQEVYPKEKSYKCDECGKTFSVSAHLVQHQRIHTGEKPYLCTVCGKSFSRSSFLIEHQRIHTGERPYLCRQCGKSFSQLCNLIRHQGVHTGNKPHKCDECGKAFSRNSGLIQHQRIHTGEKPYKCEKCDKSFSQQRSLVNHQKIHAEVKTQETHECDACGEAFNCRISLIQHQKLHTAWMQ
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
...
# Domain name Pos
1 KRAB 14..89
2 C2h2 148..170
3 C2h2 176..198
4 C2h2 204..226
5 C2h2 232..254
6 C2h2 260..282
7 C2h2 288..310
8 C2h2 316..338
9 C2h2 344..366
10 C2h2 372..394
11 C2h2 400..422
12 C2h2 456..478
13 C2h2 484..506
14 C2h2 512..534
15 C2h2 540..562
16 C2h2 568..590
17 C2h2 599..621
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L2a 591 **** 99.0 Highly correlated
2 L2c 359 **** 99.0 Highly correlated
3 L2b 340 **** 99.0 Highly correlated
4 MIRb 49 n.s 99.0 Highly correlated
5 AluJb 48 n.s 74.0 Weakly correlated
6 L2 43 * 99.0 Highly correlated
7 AluSx1 36 n.s 74.0 Weakly correlated
8 THE1B-int 34 **** 43.0 Weakly correlated
9 AluSz 33 n.s 74.0 Weakly correlated
10 MIR 33 n.s 99.0 Highly correlated
11 MIR3 29 * 99.0 Highly correlated
12 AluSx 26 n.s 74.0 Weakly correlated
13 AluY 26 n.s 74.0 Weakly correlated
14 AluJr 24 n.s 74.0 Weakly correlated
15 MIRc 24 n.s 99.0 Highly correlated
16 AluJo 21 n.s 74.0 Weakly correlated
17 THE1C-int 21 **** 43.0 Weakly correlated
18 THE1D-int 18 **** 28.9 Weakly correlated
19 LTR8 16 **** 43.0 Weakly correlated
20 AluSp 15 n.s 74.0 Weakly correlated
21 L1PA2 15 n.s 15.2 Weakly correlated
22 AluSq2 13 n.s 74.0 Weakly correlated
23 AluSx3 11 n.s 74.0 Weakly correlated
24 FLAM_C 11 * 74.0 Weakly correlated
25 AluSc 9 n.s 74.0 Weakly correlated
26 AluSq 9 n.s 74.0 Weakly correlated
27 AluSz6 9 n.s 74.0 Weakly correlated
28 AluYj4 9 **** 0.0 Weakly correlated
29 MLT1D 9 n.s 99.0 Highly correlated
30 MLT1K 8 n.s 99.0 Highly correlated
31 AluSg 7 n.s 74.0 Weakly correlated
32 HAL1 7 n.s 99.0 Highly correlated
33 L1PA3 7 n.s 19.6 Weakly correlated
34 AluSc8 6 n.s 74.0 Weakly correlated
35 L1MC4 6 n.s 99.0 Highly correlated
36 LTR1A2 6 *** 43.0 Weakly correlated
37 MSTA-int 6 n.s 43.0 Weakly correlated
38 FRAM 5 * 74.0 Weakly correlated
39 L1M5 5 n.s 99.0 Highly correlated
40 L1MB7 5 n.s 99.0 Highly correlated
41 LTR41 5 *** 99.0 Highly correlated
42 MLT1J 5 n.s 99.0 Highly correlated
43 AluYa5 4 n.s 15.2 Weakly correlated
44 L1M4 4 n.s 99.0 Highly correlated
45 L1ME4b 4 n.s 99.0 Highly correlated
46 L1MEf 4 n.s 99.0 Highly correlated
47 L3 4 n.s 99.0 Highly correlated
48 LTR41C 4 **** 99.0 Highly correlated
49 LTR50 4 * 99.0 Highly correlated
50 MER11B 4 ** 19.6 Weakly correlated
51 MIR1_Amn 4 n.s 319.0 Weakly correlated
52 MLT1A0 4 n.s 99.0 Highly correlated
53 MLT1C 4 n.s 94.0 Weakly correlated
54 THE1A-int 4 n.s 43.0 Weakly correlated
55 AluSg7 3 n.s 74.0 Weakly correlated
56 AluYe5 3 ** 74.0 Weakly correlated
57 HERVIP10F-int 3 * 28.9 Weakly correlated
58 HERVK-int 3 * 28.9 Weakly correlated
59 HERVL18-int 3 ** 43.0 Weakly correlated
60 L1M3 3 n.s 99.0 Highly correlated
61 L1ME4a 3 n.s 99.0 Highly correlated
62 LTR10A 3 *** 28.9 Weakly correlated
63 LTR4 3 **** 28.9 Weakly correlated
64 MLT1F2 3 n.s 99.0 Highly correlated
65 MLT1J2 3 n.s 99.0 Highly correlated
66 MSTA 3 n.s 43.0 Weakly correlated
67 MamRTE1 3 n.s 99.0 Highly correlated
68 THE1D 3 n.s 43.0 Weakly correlated
69 Alu 2 * 74.0 Weakly correlated
70 AluJr4 2 n.s 74.0 Weakly correlated
71 AluSc5 2 n.s 74.0 Weakly correlated
72 AluYa8 2 *** 15.2 Weakly correlated
73 AluYc 2 n.s 74.0 Weakly correlated
74 AluYk2 2 * 19.6 Weakly correlated
75 AluYm1 2 n.s 19.6 Weakly correlated
76 FLAM_A 2 n.s 74.0 Weakly correlated
77 L1M1 2 n.s 74.0 Weakly correlated
78 L1M4b 2 n.s 99.0 Highly correlated
79 L1MA5 2 n.s 87.0 Weakly correlated
80 L1MB4 2 n.s 99.0 Highly correlated
81 L1MC3 2 n.s 99.0 Highly correlated
82 L1MC5a 2 n.s 99.0 Highly correlated
83 L1MD 2 n.s 99.0 Highly correlated
84 L1MDa 2 n.s 99.0 Highly correlated
85 L1MEg 2 n.s 99.0 Highly correlated
86 L1PA10 2 n.s 74.0 Weakly correlated
87 L1PA16 2 n.s 74.0 Weakly correlated
88 L1PA5 2 n.s 19.6 Weakly correlated
89 L1PB1 2 n.s 74.0 Weakly correlated
90 L3b 2 n.s 99.0 Highly correlated
91 LTR10F 2 ** 28.9 Weakly correlated
92 LTR13 2 n.s 19.6 Weakly correlated
93 LTR16A 2 n.s 99.0 Highly correlated
94 LTR1D 2 * 43.0 Weakly correlated
95 LTR26D 2 *** 0.0 Weakly correlated
96 LTR41B 2 * 99.0 Highly correlated
97 LTR67B 2 n.s 99.0 Highly correlated
98 LTR78 2 n.s 99.0 Highly correlated
99 MER11A 2 n.s 28.9 Weakly correlated
100 MER31-int 2 n.s 99.0 Highly correlated
101 MER41G 2 *** 74.0 Weakly correlated
102 MER61A 2 * 43.0 Weakly correlated
103 MER66B 2 n.s 43.0 Weakly correlated
104 MER67C 2 n.s 99.0 Highly correlated
105 MER74A 2 n.s 99.0 Highly correlated
106 MLT1E2 2 n.s 99.0 Highly correlated
107 MLT1F 2 n.s 99.0 Highly correlated
108 MLT1O 2 n.s 99.0 Highly correlated
109 MamSINE1 2 n.s 99.0 Highly correlated
110 AluYf1 1 n.s 19.6 Weakly correlated
111 AluYg6 1 * 15.2 Weakly correlated
112 AluYh3 1 n.s 15.2 Weakly correlated
113 AluYh3a3 1 * 15.2 Weakly correlated
114 AluYh9 1 *** 15.2 Weakly correlated
115 AluYk12 1 ** 15.2 Weakly correlated
116 AmnSINE1 1 n.s 319.0 Weakly correlated
117 ERV3-16A3_I-int 1 n.s 99.0 Highly correlated
118 ERV3-16A3_LTR 1 n.s 99.0 Highly correlated
119 HAL1ME 1 n.s 99.0 Highly correlated
120 HERV9N-int 1 n.s 19.6 Weakly correlated
121 HERVE_a-int 1 n.s 28.9 Weakly correlated
122 HERVIP10FH-int 1 n.s 28.9 Weakly correlated
123 HERVS71-int 1 n.s 28.9 Weakly correlated
124 HUERS-P3-int 1 n.s 43.0 Weakly correlated
125 L1M2 1 n.s 99.0 Highly correlated
126 L1M3e 1 n.s 99.0 Highly correlated
127 L1M3f 1 n.s 87.0 Weakly correlated
128 L1M4a1 1 n.s 99.0 Highly correlated
129 L1M8 1 n.s 99.0 Highly correlated
130 L1MA4 1 n.s 87.0 Weakly correlated
131 L1MA8 1 n.s 87.0 Weakly correlated
132 L1MA9 1 n.s 99.0 Highly correlated
133 L1MB1 1 n.s 99.0 Highly correlated
134 L1MB2 1 n.s 99.0 Highly correlated
135 L1MB3 1 n.s 99.0 Highly correlated
136 L1MB5 1 n.s 99.0 Highly correlated
137 L1MB8 1 n.s 99.0 Highly correlated
138 L1MC1 1 n.s 99.0 Highly correlated
139 L1MC4a 1 n.s 99.0 Highly correlated
140 L1MC5 1 n.s 99.0 Highly correlated
141 L1MCc 1 n.s 99.0 Highly correlated
142 L1MD2 1 n.s 99.0 Highly correlated
143 L1MDb 1 n.s 99.0 Highly correlated
144 L1ME1 1 n.s 99.0 Highly correlated
145 L1ME3 1 n.s 99.0 Highly correlated
146 L1ME3A 1 n.s 99.0 Highly correlated
147 L1ME3C 1 n.s 99.0 Highly correlated
148 L1ME3D 1 n.s 99.0 Highly correlated
149 L1ME3F 1 n.s 99.0 Highly correlated
150 L1ME4c 1 n.s 99.0 Highly correlated
151 L1MEb 1 n.s 99.0 Highly correlated
152 L1MEd 1 n.s 99.0 Highly correlated
153 L1P1 1 n.s 19.6 Weakly correlated
154 L1P2 1 n.s 28.9 Weakly correlated
155 L1PA12 1 n.s 74.0 Weakly correlated
156 L1PA13 1 n.s 74.0 Weakly correlated
157 L1PA14 1 n.s 74.0 Weakly correlated
158 L1PA15 1 n.s 74.0 Weakly correlated
159 L1PA4 1 n.s 19.6 Weakly correlated
160 L1PA6 1 n.s 28.9 Weakly correlated
161 LFSINE_Vert 1 n.s 319.0 Weakly correlated
162 LTR1 1 * 43.0 Weakly correlated
163 LTR10C 1 n.s 28.9 Weakly correlated
164 LTR12C 1 n.s 19.6 Weakly correlated
165 LTR12E 1 * 19.6 Weakly correlated
166 LTR12F 1 n.s 28.9 Weakly correlated
167 LTR16 1 n.s 99.0 Highly correlated
168 LTR16C 1 n.s 99.0 Highly correlated
169 LTR16E1 1 n.s 99.0 Highly correlated
170 LTR25 1 * 43.0 Weakly correlated
171 LTR2B 1 * 19.6 Weakly correlated
172 LTR2C 1 * 19.6 Weakly correlated
173 LTR33A 1 n.s 99.0 Highly correlated
174 LTR37B 1 n.s 99.0 Highly correlated
175 LTR3A 1 ** 28.9 Weakly correlated
176 LTR45B 1 * 74.0 Weakly correlated
177 LTR53B 1 * 99.0 Highly correlated
178 LTR55 1 * 99.0 Highly correlated
179 LTR88b 1 n.s 99.0 Highly correlated
180 LTR9D 1 n.s 43.0 Weakly correlated
181 MER11C 1 n.s 19.6 Weakly correlated
182 MER21B 1 n.s 99.0 Highly correlated
183 MER31B 1 n.s 99.0 Highly correlated
184 MER34 1 n.s 87.0 Weakly correlated
185 MER34A1 1 n.s 99.0 Highly correlated
186 MER39B 1 n.s 74.0 Weakly correlated
187 MER4-int 1 n.s 74.0 Weakly correlated
188 MER41A 1 n.s 74.0 Weakly correlated
189 MER41E 1 * 74.0 Weakly correlated
190 MER4B 1 n.s 74.0 Weakly correlated
191 MER4D1 1 n.s 74.0 Weakly correlated
192 MER50-int 1 n.s 43.0 Weakly correlated
193 MER52-int 1 n.s 99.0 Highly correlated
194 MER77 1 n.s 99.0 Highly correlated
195 MER90 1 n.s 99.0 Highly correlated
196 MLT1A 1 n.s 99.0 Highly correlated
197 MLT1B 1 n.s 99.0 Highly correlated
198 MLT1E1 1 n.s 99.0 Highly correlated
199 MLT1E3 1 n.s 99.0 Highly correlated
200 MLT1G 1 n.s 99.0 Highly correlated
201 MLT1H1 1 n.s 99.0 Highly correlated
202 MLT1H2 1 n.s 99.0 Highly correlated
203 MLT1I 1 n.s 99.0 Highly correlated
204 MLT1J-int 1 n.s 99.0 Highly correlated
205 MLT1J1 1 n.s 99.0 Highly correlated
206 MLT1J2-int 1 n.s 99.0 Highly correlated
207 MLT2A2 1 n.s 74.0 Weakly correlated
208 MLT2B3 1 n.s 99.0 Highly correlated
209 MST-int 1 * 74.0 Weakly correlated
210 MSTB1 1 n.s 74.0 Weakly correlated
211 MamGyp-int 1 n.s 99.0 Highly correlated
212 MamGypLTR1d 1 * 99.0 Highly correlated
213 MamGypLTR3 1 * 99.0 Highly correlated
214 MamGypLTR3a 1 n.s 99.0 Highly correlated
215 MamGypsy2-LTR 1 * 99.0 Highly correlated
216 THE1B 1 n.s 43.0 Weakly correlated
217 THE1C 1 n.s 43.0 Weakly correlated
218 X7C_LINE 1 * 319.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L2a 531 **** 99.0 Highly correlated
2 L2c 317 **** 99.0 Highly correlated
3 L2b 302 **** 99.0 Highly correlated
4 L2 25 n.s 99.0 Highly correlated
5 MIRb 11 n.s 99.0 Highly correlated
6 MIR 9 n.s 99.0 Highly correlated
7 LTR8 8 ** 43.0 Weakly correlated
8 HAL1 5 n.s 99.0 Highly correlated
9 MIR3 4 n.s 99.0 Highly correlated
10 AluJb 4 n.s 74.0 Weakly correlated
11 THE1B-int 3 n.s 43.0 Weakly correlated
12 MIRc 3 n.s 99.0 Highly correlated
13 MER11B 3 * 19.6 Weakly correlated
14 MLT1K 3 n.s 99.0 Highly correlated
15 AluJo 3 n.s 74.0 Weakly correlated
16 L1M5 3 n.s 99.0 Highly correlated
17 LTR1A2 3 * 43.0 Weakly correlated
18 L3 3 n.s 99.0 Highly correlated
19 L1PA3 2 n.s 19.6 Weakly correlated
20 AluSz 2 n.s 74.0 Weakly correlated
21 L1MEg 2 n.s 99.0 Highly correlated
22 L1M3 2 n.s 99.0 Highly correlated
23 AluYj4 2 n.s 0.0 Weakly correlated
24 MLT1J2 2 n.s 99.0 Highly correlated
25 L1PB1 2 n.s 74.0 Weakly correlated
26 MLT1C 2 n.s 94.0 Weakly correlated
27 HERVIP10F-int 2 n.s 28.9 Weakly correlated
28 L1MEf 2 n.s 99.0 Highly correlated
29 LTR50 2 n.s 99.0 Highly correlated
30 L1MC4 2 n.s 99.0 Highly correlated
31 MSTA 2 n.s 43.0 Weakly correlated
32 HERVK-int 2 n.s 28.9 Weakly correlated
33 AluSx 2 n.s 74.0 Weakly correlated
34 MLT1D 2 n.s 99.0 Highly correlated
35 LTR4 2 *** 28.9 Weakly correlated
36 L1MB7 2 n.s 99.0 Highly correlated
37 MLT1J 2 n.s 99.0 Highly correlated
38 THE1C-int 1 n.s 43.0 Weakly correlated
39 LTR67B 1 n.s 99.0 Highly correlated
40 LTR53B 1 * 99.0 Highly correlated
41 LTR16E1 1 n.s 99.0 Highly correlated
42 LTR12F 1 n.s 28.9 Weakly correlated
43 AluSq2 1 n.s 74.0 Weakly correlated
44 AluSz6 1 n.s 74.0 Weakly correlated
45 THE1D 1 n.s 43.0 Weakly correlated
46 AluSp 1 n.s 74.0 Weakly correlated
47 MLT1F 1 n.s 99.0 Highly correlated
48 L1MB2 1 n.s 99.0 Highly correlated
49 LTR78 1 n.s 99.0 Highly correlated
50 LTR88b 1 n.s 99.0 Highly correlated
51 MER11A 1 n.s 28.9 Weakly correlated
52 MER31-int 1 n.s 99.0 Highly correlated
53 MamRTE1 1 n.s 99.0 Highly correlated
54 L1MDa 1 n.s 99.0 Highly correlated
55 L1ME4a 1 n.s 99.0 Highly correlated
56 MLT1O 1 n.s 99.0 Highly correlated
57 HERV9N-int 1 n.s 19.6 Weakly correlated
58 L1MC4a 1 n.s 99.0 Highly correlated
59 MER74A 1 n.s 99.0 Highly correlated
60 LTR41C 1 n.s 99.0 Highly correlated
61 MER67C 1 n.s 99.0 Highly correlated
62 MIR1_Amn 1 n.s 319.0 Weakly correlated
63 L1PA16 1 n.s 74.0 Weakly correlated
64 MamGypLTR3a 1 n.s 99.0 Highly correlated
65 L1MC3 1 n.s 99.0 Highly correlated
66 L1MCc 1 n.s 99.0 Highly correlated
67 MLT1A0 1 n.s 99.0 Highly correlated
68 MER34 1 n.s 87.0 Weakly correlated
69 MER31B 1 n.s 99.0 Highly correlated
70 LTR41 1 n.s 99.0 Highly correlated
71 LTR33A 1 n.s 99.0 Highly correlated
72 THE1B 1 n.s 43.0 Weakly correlated
73 LTR1D 1 n.s 43.0 Weakly correlated
74 AluSx3 1 n.s 74.0 Weakly correlated
75 AluY 1 n.s 74.0 Weakly correlated
76 LTR12C 1 n.s 19.6 Weakly correlated
77 MER66B 1 n.s 43.0 Weakly correlated
78 L1PA12 1 n.s 74.0 Weakly correlated
79 LTR26D 1 * 0.0 Weakly correlated
80 LTR41B 1 n.s 99.0 Highly correlated
81 MLT1F2 1 n.s 99.0 Highly correlated
82 MLT1J-int 1 n.s 99.0 Highly correlated
83 MamGypLTR3 1 * 99.0 Highly correlated
84 HERVS71-int 1 n.s 28.9 Weakly correlated
85 L1M1 1 n.s 74.0 Weakly correlated
86 L1MD 1 n.s 99.0 Highly correlated
87 L1ME4b 1 n.s 99.0 Highly correlated
88 L1PA13 1 n.s 74.0 Weakly correlated
89 MamSINE1 1 n.s 99.0 Highly correlated
90 MER61A 1 n.s 43.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP