ZRdb KZFP & Repeats
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Human_ZNF184

  • Protein
    Zinc finger protein 184
  • Length
    751
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    99.0 Mya
  • Uniprot_ID
    Q99676
  • NCBI_ID
    7738
Sequence:
MEDLSSPDSTLLQGGHNLLSSASFQEAVTFKDVIVDFTQEEWKQLDPGQRDLFRDVTLENYTHLVSIGLQVSKPDVISQLEQGTEPWIMEPSIPVGTCADWETRLENSVSAPEPDISEEELSPEVIVEKHKRDDSWSSNLLESWEYEGSLERQQANQQTLPKEIKVTEKTIPSWEKGPVNNEFGKSVNVSSNLVTQEPSPEETSTKRSIKQNSNPVKKEKSCKCNECGKAFSYCSALIRHQRTHTGEKPYKCNECEKAFSRSENLINHQRIHTGDKPYKCDQCGKGFIEGPSLTQHQRIHTGEKPYKCDECGKAFSQRTHLVQHQRIHTGEKPYTCNECGKAFSQRGHFMEHQKIHTGEKPFKCDECDKTFTRSTHLTQHQKIHTGEKTYKCNECGKAFNGPSTFIRHHMIHTGEKPYECNECGKAFSQHSNLTQHQKTHTGEKPYDCAECGKSFSYWSSLAQHLKIHTGEKPYKCNECGKAFSYCSSLTQHRRIHTREKPFECSECGKAFSYLSNLNQHQKTHTQEKAYECKECGKAFIRSSSLAKHERIHTGEKPYQCHECGKTFSYGSSLIQHRKIHTGERPYKCNECGRAFNQNIHLTQHKRIHTGAKPYECAECGKAFRHCSSLAQHQKTHTEEKPYQCNKCEKTFSQSSHLTQHQRIHTGEKPYKCNECDKAFSRSTHLTEHQNTHTGEKPYNCNECRKTFSQSTYLIQHQRIHSGEKPFGCNDCGKSFRYRSALNKHQRLHPGI
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 28..99
2 C2h2 222..244
3 C2h2 250..272
4 C2h2 278..300
5 C2h2 306..328
6 C2h2 334..356
7 C2h2 362..384
8 C2h2 390..412
9 C2h2 418..440
10 C2h2 446..468
11 C2h2 474..496
12 C2h2 502..524
13 C2h2 530..552
14 C2h2 558..580
15 C2h2 586..608
16 C2h2 614..636
17 C2h2 642..664
18 C2h2 670..692
19 C2h2 698..720
20 C2h2 726..748
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
4 Molecular Function zinc ion binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1ME1 32 **** 99.0 Highly correlated
2 L1MB7 22 **** 99.0 Highly correlated
3 L1M5 15 **** 99.0 Highly correlated
4 LTR10A 10 **** 28.9 Weakly correlated
5 L1ME2 10 **** 99.0 Highly correlated
6 L2c 9 n.s 99.0 Highly correlated
7 L1MB8 8 *** 99.0 Highly correlated
8 AluSx 6 n.s 74.0 Weakly correlated
9 MIRb 6 n.s 99.0 Highly correlated
10 LTR76 5 **** 74.0 Weakly correlated
11 L2 5 n.s 99.0 Highly correlated
12 L1M4 4 n.s 99.0 Highly correlated
13 L1ME3G 4 ** 99.0 Highly correlated
14 AluY 4 n.s 74.0 Weakly correlated
15 L1MD2 4 * 99.0 Highly correlated
16 L1ME2z 3 ** 99.0 Highly correlated
17 MLT1C 3 n.s 94.0 Weakly correlated
18 MIR3 3 n.s 99.0 Highly correlated
19 L1ME5 3 *** 99.0 Highly correlated
20 AluJb 3 n.s 74.0 Weakly correlated
21 FLAM_C 3 * 74.0 Weakly correlated
22 L2a 3 n.s 99.0 Highly correlated
23 L2b 3 n.s 99.0 Highly correlated
24 AluSx1 3 n.s 74.0 Weakly correlated
25 AluSc8 3 n.s 74.0 Weakly correlated
26 AluJr 3 n.s 74.0 Weakly correlated
27 L1ME3B 2 * 99.0 Highly correlated
28 LTR18A 2 **** 43.0 Weakly correlated
29 L1ME3A 2 n.s 99.0 Highly correlated
30 MIR 2 n.s 99.0 Highly correlated
31 L1PA5 2 n.s 19.6 Weakly correlated
32 LTR4 2 **** 28.9 Weakly correlated
33 L1MA8 2 n.s 87.0 Weakly correlated
34 THE1B 2 n.s 43.0 Weakly correlated
35 L1M2 2 n.s 99.0 Highly correlated
36 AluSz 2 n.s 74.0 Weakly correlated
37 HERV3-int 2 *** 28.9 Weakly correlated
38 L1MD 2 * 99.0 Highly correlated
39 MLT1J 2 n.s 99.0 Highly correlated
40 MER11D 1 ** 19.6 Weakly correlated
41 L1MEh 1 * 99.0 Highly correlated
42 LTR37B 1 ** 99.0 Highly correlated
43 SVA_C 1 ** 15.2 Weakly correlated
44 LTR47A 1 ** 74.0 Weakly correlated
45 MamGypLTR1a 1 ** 99.0 Highly correlated
46 MSTB 1 n.s 43.0 Weakly correlated
47 MLT1L 1 n.s 99.0 Highly correlated
48 MLT1I 1 n.s 99.0 Highly correlated
49 LTR79 1 * 99.0 Highly correlated
50 MER39B 1 ** 74.0 Weakly correlated
51 MER41D 1 *** 74.0 Weakly correlated
52 MLT1G3 1 * 99.0 Highly correlated
53 MER50 1 * 43.0 Weakly correlated
54 MER54A 1 ** 87.0 Weakly correlated
55 MLT1E3 1 * 99.0 Highly correlated
56 MLT1D 1 n.s 99.0 Highly correlated
57 MLT1B 1 n.s 99.0 Highly correlated
58 MIRc 1 n.s 99.0 Highly correlated
59 L1MC4 1 n.s 99.0 Highly correlated
60 AluJo 1 n.s 74.0 Weakly correlated
61 AluSg 1 n.s 74.0 Weakly correlated
62 AluSx3 1 n.s 74.0 Weakly correlated
63 AluSz6 1 n.s 74.0 Weakly correlated
64 AluYc 1 * 74.0 Weakly correlated
65 AluYj4 1 * 0.0 Weakly correlated
66 HAL1 1 n.s 99.0 Highly correlated
67 HERVL-int 1 n.s 74.0 Weakly correlated
68 L1M4a1 1 * 99.0 Highly correlated
69 L1MA1 1 n.s 74.0 Weakly correlated
70 L1MA7 1 n.s 87.0 Weakly correlated
71 L1MB4 1 n.s 99.0 Highly correlated
72 L1MC2 1 n.s 99.0 Highly correlated
73 LTR16A 1 * 99.0 Highly correlated
74 L1MC5a 1 n.s 99.0 Highly correlated
75 L1ME3 1 n.s 99.0 Highly correlated
76 L1ME3Cz 1 n.s 99.0 Highly correlated
77 L1ME4a 1 n.s 99.0 Highly correlated
78 L1MEg 1 n.s 99.0 Highly correlated
79 L1P1 1 n.s 19.6 Weakly correlated
80 L1PA2 1 n.s 15.2 Weakly correlated
81 L1PA4 1 n.s 19.6 Weakly correlated
82 L3 1 n.s 99.0 Highly correlated
83 L3b 1 n.s 99.0 Highly correlated
84 LTR10G 1 *** 28.9 Weakly correlated
85 LTR12C 1 n.s 19.6 Weakly correlated
86 LTR13 1 ** 19.6 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1ME1 2 n.s 99.0 Highly correlated
2 L1ME3 1 n.s 99.0 Highly correlated
3 AluYj4 1 * 0.0 Weakly correlated
4 AluSz6 1 n.s 74.0 Weakly correlated
5 L1MD2 1 n.s 99.0 Highly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP