ZRdb KZFP & Repeats
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Human_ZNF181

  • Protein
    Zinc finger protein 181
  • Length
    571
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    94.0 Mya
  • Uniprot_ID
    Q2M3W8
  • NCBI_ID
    339318
Sequence:
MPQVTFNDVAIDFTHEEWGWLSSAQRDLYKDVMVQNYENLVSVAGLSVTKPYVITLLEDGKEPWMMEKKLSKGMIPDWESRWENKELSTKKDNYDEDSPQTVIIEKVVKQSYEFSNSKKNLEYIEKLEGKHGSQVDHFRPAILTSRESPTADSVYKYNIFRSTFHSKSTLSEPQKISAEGNSHKYDILKKNLPKKSVIKNEKVNGGKKLLNSNKSGAAFSQGKSLTLPQTCNREKIYTCSECGKAFGKQSILNRHWRIHTGEKPYECRECGKTFSHGSSLTRHLISHSGEKPYKCIECGKAFSHVSSLTNHQSTHTGEKPYECMNCGKSFSRVSHLIEHLRIHTQEKLYECRICGKAFIHRSSLIHHQKIHTGEKPYECRECGKAFCCSSHLTRHQRIHTMEKQYECNKCLKVFSSLSFLVQHQSIHTEEKPFECQKCRKSFNQLESLNMHLRNHIRLKPYECSICGKAFSHRSSLLQHHRIHTGEKPYECIKCGKTFSCSSNLTVHQRIHTGEKPYKCNECGKAFSKGSNLTAHQRVHNGEKPNSVVSVEKPLDYMNHYTCEKSYRRETV
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 4..76
2 C2h2 237..259
3 C2h2 265..287
4 C2h2 293..315
5 C2h2 321..343
6 C2h2 349..371
7 C2h2 377..399
8 C2h2 405..427
9 C2h2 433..455
10 C2h2 461..483
11 C2h2 489..511
12 C2h2 517..539
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 MLT1E2 32 **** 99.0 Moderately correlated
2 MLT1E1A 9 **** 99.0 Moderately correlated
3 MLT1E3 8 **** 99.0 Moderately correlated
4 L1PA5 4 n.s 19.6 Weakly correlated
5 MLT1E 3 **** 99.0 Moderately correlated
6 LTR10A 3 **** 28.9 Weakly correlated
7 LTR10F 2 **** 28.9 Weakly correlated
8 MLT1E1 2 **** 99.0 Moderately correlated
9 L1PA2 2 n.s 15.2 Weakly correlated
10 MER50-int 1 ** 43.0 Weakly correlated
11 LTR18A 1 **** 43.0 Weakly correlated
12 LTR41B 1 *** 99.0 Moderately correlated
13 MER39B 1 ** 74.0 Weakly correlated
14 MER50 1 ** 43.0 Weakly correlated
15 LTR10D 1 **** 28.9 Weakly correlated
16 MIR 1 n.s 99.0 Moderately correlated
17 THE1B 1 n.s 43.0 Weakly correlated
18 LTR13 1 ** 19.6 Weakly correlated
19 AluJb 1 n.s 74.0 Weakly correlated
20 L2c 1 n.s 99.0 Moderately correlated
21 L2b 1 n.s 99.0 Moderately correlated
22 L1PREC2 1 n.s 43.0 Weakly correlated
23 L1P1 1 n.s 19.6 Weakly correlated
24 HERVL18-int 1 ** 43.0 Weakly correlated
25 FLAM_A 1 * 74.0 Weakly correlated
26 AluYm1 1 * 19.6 Weakly correlated
27 AluY 1 n.s 74.0 Weakly correlated
28 AluSz 1 n.s 74.0 Weakly correlated
29 AluSx 1 n.s 74.0 Weakly correlated
30 AluJr 1 n.s 74.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 MLT1E2 27 **** 99.0 Moderately correlated
2 MLT1E1A 9 **** 99.0 Moderately correlated
3 MLT1E3 7 **** 99.0 Moderately correlated
4 MLT1E 3 **** 99.0 Moderately correlated
5 MLT1E1 2 **** 99.0 Moderately correlated
6 LTR18A 1 **** 43.0 Weakly correlated
7 HERVL18-int 1 ** 43.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP