ZRdb KZFP & Repeats
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Human_ZNF180

  • Protein
    Zinc finger protein 180
  • Length
    692
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    99.0 Mya
  • Uniprot_ID
    Q9UJW8
  • NCBI_ID
    7733
Sequence:
MRACAGSTREAGSGAQDLSTLLCLEESMEEQDEKPPEPPKACAQDSFLPQEIIIKVEGEDTGSLTIPSQEGVNFKIVTVDFTREEQGTWNPAQRTLDRDVILENHRDLVSWDLATAVGKKDSTSKQRIFDEEPANGVKIERFTRDDPWLSSCEEVDDCKDQLEKQQEKQEILLQEVAFTQRKAVIHERVCKSDETGEKSGLNSSLFSSPVIPIRNHFHKHVSHAKKWHLNAAVNSHQKINENETLYENNECGKPPQSIHLIQFTRTQTKDKCYGFSDRIQSFCHGTPLHIHEKIHGGGKTFDFKECGQVLNPKISHNEQQRIPFEESQYKCSETSHSSSLTQNMRNNSEEKPFECNQCGKSFSWSSHLVAHQRTHTGEKPYECSECGKSFSRSSHLVSHQRTHTGEKPYRCNQCGKSFSQSYVLVVHQRTHTGEKPYECNQCGKSFRQSYKLIAHQRTHTGEKPYECNQCGKSFIQSYKLIAHQRIHTGEKPYECNQCGKSFSQSYKLVAHQRTHTGEKPFECNQCGKSFSWSSQLVAHQRTHTGEKPYECSECGKSFNRSSHLVMHQRIHTGEKPYECNQCGKSFSQSYVLVVHQRTHTGEKPYECSQCGKSFRQSSCLTQHQRTHTGEKPFECNQCGKTFSLSARLIVHQRTHTGEKPFTCIQCGKAFINSYKLIRHQATHTEEKLYECN
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 72..145
2 C2h2 353..375
3 C2h2 381..403
4 C2h2 409..431
5 C2h2 437..459
6 C2h2 465..487
7 C2h2 493..515
8 C2h2 521..543
9 C2h2 549..571
10 C2h2 577..599
11 C2h2 605..627
12 C2h2 633..655
13 C2h2 661..683
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function DNA-binding transcription repressor activity, RNA polymerase II-specific
4 Molecular Function metal ion binding
5 Molecular Function RNA polymerase II transcription regulatory region sequence-specific DNA binding
6 Biological Process negative regulation of transcription by RNA polymerase II
7 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 MIRb 7 n.s 99.0 Highly correlated
2 AluY 7 n.s 74.0 Weakly correlated
3 AluJb 5 n.s 74.0 Weakly correlated
4 AluSx1 5 n.s 74.0 Weakly correlated
5 L2a 5 n.s 99.0 Highly correlated
6 AluJr 4 n.s 74.0 Weakly correlated
7 MIR3 4 n.s 99.0 Highly correlated
8 MIR 4 n.s 99.0 Highly correlated
9 L1P3 4 ** 74.0 Weakly correlated
10 AluSp 4 n.s 74.0 Weakly correlated
11 L2c 4 n.s 99.0 Highly correlated
12 LTR10A 3 **** 28.9 Weakly correlated
13 L1PA5 3 n.s 19.6 Weakly correlated
14 L2 3 n.s 99.0 Highly correlated
15 AluSz6 3 n.s 74.0 Weakly correlated
16 L2b 2 n.s 99.0 Highly correlated
17 AluJo 2 n.s 74.0 Weakly correlated
18 LTR10F 2 **** 28.9 Weakly correlated
19 MER31A 2 *** 87.0 Weakly correlated
20 L1PA2 2 n.s 15.2 Weakly correlated
21 MER50 2 * 43.0 Weakly correlated
22 L1M2 2 n.s 99.0 Highly correlated
23 L1M1 2 n.s 74.0 Weakly correlated
24 AluSc5 2 * 74.0 Weakly correlated
25 FRAM 2 * 74.0 Weakly correlated
26 MER65C 1 ** 74.0 Weakly correlated
27 LTR16C 1 n.s 99.0 Highly correlated
28 LTR1A2 1 * 43.0 Weakly correlated
29 LTR9 1 ** 43.0 Weakly correlated
30 MER101 1 *** 74.0 Weakly correlated
31 AluSq2 1 n.s 74.0 Weakly correlated
32 MER39B 1 * 74.0 Weakly correlated
33 MER41B 1 n.s 74.0 Weakly correlated
34 AluSg 1 n.s 74.0 Weakly correlated
35 MER50-int 1 * 43.0 Weakly correlated
36 AluSx 1 n.s 74.0 Weakly correlated
37 AluSc8 1 n.s 74.0 Weakly correlated
38 MIR1_Amn 1 n.s 319.0 Weakly correlated
39 AluSc 1 n.s 74.0 Weakly correlated
40 MIRc 1 n.s 99.0 Highly correlated
41 MLT1C 1 n.s 94.0 Weakly correlated
42 MLT1D 1 n.s 99.0 Highly correlated
43 SVA_D 1 n.s 15.2 Weakly correlated
44 AluYm1 1 n.s 19.6 Weakly correlated
45 L1MA8 1 n.s 87.0 Weakly correlated
46 L1MA9 1 n.s 99.0 Highly correlated
47 L1MB8 1 n.s 99.0 Highly correlated
48 L1MCa 1 n.s 99.0 Highly correlated
49 L1ME2z 1 n.s 99.0 Highly correlated
50 L1P1 1 n.s 19.6 Weakly correlated
51 L1P4 1 n.s 74.0 Weakly correlated
52 FLAM_C 1 n.s 74.0 Weakly correlated
53 L1PA4 1 n.s 19.6 Weakly correlated
54 LTR13 1 * 19.6 Weakly correlated
55 L1PBa 1 n.s 74.0 Weakly correlated
56 L1PREC2 1 n.s 43.0 Weakly correlated
57 AluYh9 1 **** 15.2 Weakly correlated
58 AluYc 1 n.s 74.0 Weakly correlated
59 AluYa5 1 n.s 15.2 Weakly correlated
60 AluSz 1 n.s 74.0 Weakly correlated
61 L3b 1 n.s 99.0 Highly correlated
62 AluSx4 1 n.s 74.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1PA2 1 n.s 15.2 Weakly correlated
2 L2a 1 n.s 99.0 Highly correlated
3 MER31A 1 * 87.0 Weakly correlated
4 MIRb 1 n.s 99.0 Highly correlated
5 L2c 1 n.s 99.0 Highly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP