ZRdb KZFP & Repeats
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Human_ZNF177

  • Protein
    Zinc finger protein 177
  • Length
    481
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    94.0 Mya
  • Time of Changing in binding specificity
    94.0 Mya
  • Uniprot_ID
    Q13360
  • NCBI_ID
    7730
Sequence:
MAAGWLTTWSQNSVTFQEVAVDFSQEEWALLDPAQKNLYKDVMLENFRNLASVGYQLCRHSLISKVDQEQLKTDERGILQGDCADWETQLKPKDTIAMQNIPGGKTSNGINTAENQPGEHSLECNHCGKFRKNTRFICTRYCKGEKCYKYIKYSKVFNHPSTLRSHVSIHIGEKTLEFTDCRKAFNQESSLRKHLRTPTGQKFQEYEQCDMSFSLHSSCSVREQIPTGEKGDECSDYGKISPLSVHTKTGSVEEGLECNEHEKTFTDPLSLQNCVRTHSGEMPYECSDCGKAFIFQSSLKKHMRSHTGEKPYECDHCGKSFSQSSHLNVHKRTHTGEKPYDCKECGKAFTVPSSLQKHVRTHTGEKPYECSDCGKAFIDQSSLKKHTRSHTGEKPYECNQCGKSFSTGSYLIVHKRTHTGEKTYECKECGKAFRNSSCLRVHVRTHTGEKPYKCIQCEKAFSTSTNLIMHKRIHNGQKLHE
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 14..84
2 dec2h2 145..170
3 dec2h2 176..198
4 C2h2 256..278
5 C2h2 284..306
6 C2h2 312..334
7 C2h2 340..362
8 C2h2 368..390
9 C2h2 396..418
10 C2h2 424..446
11 C2h2 452..474
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component blood microparticle
2 Cellular Component nucleus
3 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
4 Molecular Function DNA-binding transcription repressor activity, RNA polymerase II-specific
5 Molecular Function metal ion binding
6 Molecular Function RNA polymerase II transcription regulatory region sequence-specific DNA binding
7 Molecular Function sequence-specific double-stranded DNA binding
8 Biological Process negative regulation of transcription by RNA polymerase II
9 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 AluJb 14 n.s 74.0 Weakly correlated
2 L1P3 13 **** 74.0 Weakly correlated
3 LTR8 7 **** 43.0 Weakly correlated
4 AluSc8 7 * 74.0 Weakly correlated
5 AluYj4 6 **** 0.0 Weakly correlated
6 AluSp 5 n.s 74.0 Weakly correlated
7 ERV3-16A3_I-int 4 n.s 99.0 Moderately correlated
8 MER52A 4 ** 74.0 Weakly correlated
9 MER21B 4 ** 99.0 Moderately correlated
10 LTR10A 4 **** 28.9 Weakly correlated
11 AluY 3 n.s 74.0 Weakly correlated
12 L2c 3 n.s 99.0 Moderately correlated
13 AluSx 3 n.s 74.0 Weakly correlated
14 MLT1E3 2 ** 99.0 Moderately correlated
15 LTR10F 2 *** 28.9 Weakly correlated
16 L1MB8 2 n.s 99.0 Moderately correlated
17 MER61C 2 **** 43.0 Weakly correlated
18 L1M4 2 n.s 99.0 Moderately correlated
19 L1PA5 2 n.s 19.6 Weakly correlated
20 MIRb 2 n.s 99.0 Moderately correlated
21 MIRc 2 n.s 99.0 Moderately correlated
22 AluSx1 2 n.s 74.0 Weakly correlated
23 HAL1 2 n.s 99.0 Moderately correlated
24 FRAM 2 * 74.0 Weakly correlated
25 LTR13 2 ** 19.6 Weakly correlated
26 L1PA2 2 n.s 15.2 Weakly correlated
27 AluSz6 2 n.s 74.0 Weakly correlated
28 L1PA3 2 n.s 19.6 Weakly correlated
29 LTR28C 1 ** 43.0 Weakly correlated
30 LTR5_Hs 1 n.s 0.0 Weakly correlated
31 LTR12C 1 n.s 19.6 Weakly correlated
32 MIR3 1 n.s 99.0 Moderately correlated
33 MER52D 1 n.s 74.0 Weakly correlated
34 MER54A 1 * 87.0 Weakly correlated
35 MIR 1 n.s 99.0 Moderately correlated
36 MIR1_Amn 1 n.s 319.0 Weakly correlated
37 L1PA10 1 n.s 74.0 Weakly correlated
38 MLT1K 1 n.s 99.0 Moderately correlated
39 MLT1L 1 n.s 99.0 Moderately correlated
40 MLT2A1 1 n.s 74.0 Weakly correlated
41 MLT2B3 1 n.s 99.0 Moderately correlated
42 MSTA 1 n.s 43.0 Weakly correlated
43 MSTA-int 1 n.s 43.0 Weakly correlated
44 SVA_A 1 * 19.6 Weakly correlated
45 SVA_D 1 n.s 15.2 Weakly correlated
46 X6A_LINE 1 ** 99.0 Moderately correlated
47 L1MA2 1 n.s 74.0 Weakly correlated
48 AluJo 1 n.s 74.0 Weakly correlated
49 AluJr 1 n.s 74.0 Weakly correlated
50 AluSc 1 n.s 74.0 Weakly correlated
51 AluSg4 1 n.s 74.0 Weakly correlated
52 AluSq2 1 n.s 74.0 Weakly correlated
53 AluSz 1 n.s 74.0 Weakly correlated
54 AluYh9 1 **** 15.2 Weakly correlated
55 AluYm1 1 n.s 19.6 Weakly correlated
56 FLAM_A 1 n.s 74.0 Weakly correlated
57 HERVIP10FH-int 1 * 28.9 Weakly correlated
58 L1HS 1 n.s 8.6 Weakly correlated
59 L1M1 1 n.s 74.0 Weakly correlated
60 L1M3 1 n.s 99.0 Moderately correlated
61 LTR10B1 1 *** 28.9 Weakly correlated
62 L1MA4 1 n.s 87.0 Weakly correlated
63 L1MA9 1 n.s 99.0 Moderately correlated
64 L1MC4 1 n.s 99.0 Moderately correlated
65 L1MC5a 1 n.s 99.0 Moderately correlated
66 L1MDa 1 n.s 99.0 Moderately correlated
67 L1MEc 1 n.s 99.0 Moderately correlated
68 L1P1 1 n.s 19.6 Weakly correlated
69 L1P4 1 n.s 74.0 Weakly correlated
70 L1PA14 1 n.s 74.0 Weakly correlated
71 L1PA17 1 n.s 74.0 Weakly correlated
72 L2b 1 n.s 99.0 Moderately correlated
73 LTR105_Mam 1 ** 99.0 Moderately correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 AluSc8 5 n.s 74.0 Weakly correlated
2 AluY 3 n.s 74.0 Weakly correlated
3 L1PA2 1 n.s 15.2 Weakly correlated
4 AluYm1 1 n.s 19.6 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP