ZRdb KZFP & Repeats
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Human_ZNF17

  • Protein
    Zinc finger protein 17
  • Length
    662
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    94.0 Mya
  • Time of Changing in binding specificity
    69.0 Mya
  • Uniprot_ID
    P17021
  • NCBI_ID
    7565
Sequence:
MNLTEDYMVFEDVAIHFSQEEWGILNDVQRHLHSDVMLENFALLSSVGCWHGAKDEEAPSKQCVSVGVSQVTTLKPALSTQKAQPCETCSSLLKDILHLAEHDGTHPKRTAKLYLHQKEHLREKLTRSDEGRPSFVNDSVHLAKRNLTCMQGGKDFTGDSDLQQQALHSGWKPHRDTHGVEAFQSGQNNYSCTQCGKDFCHQHTLFEHQKIHTEERPYECSECGKLFRYNSDLIKHQRNHTGERPYKCSECGKAFSLKYNVVQHQKIHTGERPYECSECGKAFLRKSHLLQHQRIHTRPRPYVCSECGKAFLTQAHLVGHQKIHTGERPYGCNECGKYFMYSSALIRHQKVHTGERPFYCCECGKFFMDSCTLIIHQRVHTGEKPYECNECGKFFRYRSTLIRHQKVHTGEKPYECSECGKFFMDTSTLIIHQRVHTGEKPYECNKCGKFFRYCFTLNRHQRVHSGERPYECSECGKFFVDSCTLKSHQRVHTGERPFECSICGKSFRCRSTLDTHQRIHTGERPYECSECGKFFRHNSNHIRHRRNHFGERSFECTECGRVFSQNSHLIRHQKVHTRERTYKCSKCGKFFMDSSTLISHERVHTGEKPYECSECGKVFRYNSSLIKHRRIHTGERPYQCSECGRVFNQNSHLIQHQKVHTR
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 8..101
2 C2h2 190..212
3 C2h2 218..240
4 C2h2 246..268
5 C2h2 274..296
6 C2h2 302..324
7 C2h2 358..380
8 C2h2 386..408
9 C2h2 414..436
10 C2h2 442..464
11 C2h2 470..492
12 C2h2 498..520
13 C2h2 526..548
14 C2h2 554..576
15 C2h2 582..604
16 C2h2 610..632
17 C2h2 638..660
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1PA7 410 **** 74.0 Moderately correlated
2 MLT2B4 275 **** 99.0 Weakly correlated
3 L1P3 109 **** 74.0 Moderately correlated
4 L1PA3 103 **** 19.6 Weakly correlated
5 MLT2B1 66 **** 99.0 Weakly correlated
6 L2a 46 n.s 99.0 Weakly correlated
7 L1PA8 44 **** 74.0 Moderately correlated
8 L1PA4 36 **** 19.6 Weakly correlated
9 MLT2D 33 **** 99.0 Weakly correlated
10 L1PA5 30 *** 19.6 Weakly correlated
11 AluJb 29 n.s 74.0 Moderately correlated
12 L2c 28 n.s 99.0 Weakly correlated
13 L1P2 26 **** 28.9 Weakly correlated
14 L1PA2 19 ** 15.2 Weakly correlated
15 MIRb 19 n.s 99.0 Weakly correlated
16 L2 17 n.s 99.0 Weakly correlated
17 AluJr 16 n.s 74.0 Moderately correlated
18 L2b 16 n.s 99.0 Weakly correlated
19 AluJo 14 n.s 74.0 Moderately correlated
20 AluSx 14 n.s 74.0 Moderately correlated
21 L1MB8 13 * 99.0 Weakly correlated
22 MIR 13 n.s 99.0 Weakly correlated
23 AluY 11 n.s 74.0 Moderately correlated
24 L1P1 11 **** 19.6 Weakly correlated
25 AluSz 9 n.s 74.0 Moderately correlated
26 MIRc 9 n.s 99.0 Weakly correlated
27 HAL1 8 n.s 99.0 Weakly correlated
28 L1M4 8 n.s 99.0 Weakly correlated
29 MIR3 8 n.s 99.0 Weakly correlated
30 MLT1D 8 n.s 99.0 Weakly correlated
31 MSTA 8 n.s 43.0 Weakly correlated
32 AluSx1 7 n.s 74.0 Moderately correlated
33 L1MA4 7 n.s 87.0 Weakly correlated
34 L1MC4 7 n.s 99.0 Weakly correlated
35 L1ME1 7 n.s 99.0 Weakly correlated
36 L1ME4b 7 n.s 99.0 Weakly correlated
37 L1PA10 7 n.s 74.0 Moderately correlated
38 L1PA6 7 n.s 28.9 Weakly correlated
39 LTR18B 7 **** 43.0 Weakly correlated
40 AluSp 6 n.s 74.0 Moderately correlated
41 AluSz6 6 n.s 74.0 Moderately correlated
42 HERVK-int 6 **** 28.9 Weakly correlated
43 L1MEd 6 n.s 99.0 Weakly correlated
44 L1MEf 6 n.s 99.0 Weakly correlated
45 L1PA11 6 n.s 74.0 Moderately correlated
46 LTR8 6 *** 43.0 Weakly correlated
47 MLT1J 6 n.s 99.0 Weakly correlated
48 MSTB1 6 ** 74.0 Moderately correlated
49 L1M5 5 n.s 99.0 Weakly correlated
50 L1MB3 5 n.s 99.0 Weakly correlated
51 L1MB7 5 n.s 99.0 Weakly correlated
52 L1PREC2 5 n.s 43.0 Weakly correlated
53 MLT1B 5 n.s 99.0 Weakly correlated
54 MLT2B2 5 **** 99.0 Weakly correlated
55 AluJr4 4 n.s 74.0 Moderately correlated
56 L1MA2 4 n.s 74.0 Moderately correlated
57 L1MA4A 4 n.s 87.0 Weakly correlated
58 L1MA7 4 n.s 87.0 Weakly correlated
59 L1MA9 4 n.s 99.0 Weakly correlated
60 L1MB4 4 n.s 99.0 Weakly correlated
61 L1MEc 4 n.s 99.0 Weakly correlated
62 L1PA13 4 n.s 74.0 Moderately correlated
63 L1PA17 4 n.s 74.0 Moderately correlated
64 MLT1G1 4 ** 99.0 Weakly correlated
65 MLT2C2 4 **** 99.0 Weakly correlated
66 THE1B 4 n.s 43.0 Weakly correlated
67 AluSg 3 n.s 74.0 Moderately correlated
68 AluSq 3 n.s 74.0 Moderately correlated
69 AluSq2 3 n.s 74.0 Moderately correlated
70 AluSx3 3 n.s 74.0 Moderately correlated
71 FAM 3 ** 87.0 Weakly correlated
72 FLAM_A 3 n.s 74.0 Moderately correlated
73 L1HS 3 n.s 8.6 Weakly correlated
74 L1M4b 3 n.s 99.0 Weakly correlated
75 L1MA1 3 n.s 74.0 Moderately correlated
76 L1MA3 3 n.s 74.0 Moderately correlated
77 L1MA5A 3 n.s 87.0 Weakly correlated
78 L1MB2 3 n.s 99.0 Weakly correlated
79 L1MC1 3 n.s 99.0 Weakly correlated
80 L1ME3A 3 n.s 99.0 Weakly correlated
81 L3 3 n.s 99.0 Weakly correlated
82 LTR10A 3 **** 28.9 Weakly correlated
83 LTR16E1 3 ** 99.0 Weakly correlated
84 LTR33 3 n.s 99.0 Weakly correlated
85 LTR50 3 ** 99.0 Weakly correlated
86 MER57C2 3 **** 87.0 Weakly correlated
87 MLT1A 3 n.s 99.0 Weakly correlated
88 MLT1C 3 n.s 94.0 Weakly correlated
89 MLT1F 3 * 99.0 Weakly correlated
90 MLT1G3 3 * 99.0 Weakly correlated
91 THE1B-int 3 n.s 43.0 Weakly correlated
92 THE1C 3 n.s 43.0 Weakly correlated
93 AluSc 2 n.s 74.0 Moderately correlated
94 AluSc8 2 n.s 74.0 Moderately correlated
95 AluSg7 2 n.s 74.0 Moderately correlated
96 AluYc 2 n.s 74.0 Moderately correlated
97 AluYj4 2 * 0.0 Weakly correlated
98 FLAM_C 2 n.s 74.0 Moderately correlated
99 HAL1M8 2 n.s 99.0 Weakly correlated
100 HAL1ME 2 n.s 99.0 Weakly correlated
101 L1M2a 2 ** 87.0 Weakly correlated
102 L1M4c 2 n.s 99.0 Weakly correlated
103 L1MA6 2 n.s 87.0 Weakly correlated
104 L1MA8 2 n.s 87.0 Weakly correlated
105 L1MC3 2 n.s 99.0 Weakly correlated
106 L1MD 2 n.s 99.0 Weakly correlated
107 L1MD1 2 n.s 99.0 Weakly correlated
108 L1MD2 2 n.s 99.0 Weakly correlated
109 L1ME3F 2 n.s 99.0 Weakly correlated
110 L1MEi 2 n.s 99.0 Weakly correlated
111 L1PA8A 2 n.s 74.0 Moderately correlated
112 L1PB4 2 n.s 99.0 Weakly correlated
113 LTR12C 2 n.s 19.6 Weakly correlated
114 LTR16B1 2 ** 99.0 Weakly correlated
115 LTR18A 2 **** 43.0 Weakly correlated
116 LTR5A 2 ** 19.6 Weakly correlated
117 LTR7 2 n.s 19.6 Weakly correlated
118 MER101 2 *** 74.0 Moderately correlated
119 MER101-int 2 * 74.0 Moderately correlated
120 MER4E 2 ** 74.0 Moderately correlated
121 MER50 2 n.s 43.0 Weakly correlated
122 MER52A 2 n.s 74.0 Moderately correlated
123 MER65-int 2 * 87.0 Weakly correlated
124 MER66-int 2 * 43.0 Weakly correlated
125 MIR1_Amn 2 n.s 319.0 Weakly correlated
126 MLT1A0 2 n.s 99.0 Weakly correlated
127 MLT1F2 2 n.s 99.0 Weakly correlated
128 MLT1G 2 n.s 99.0 Weakly correlated
129 MLT1J1 2 n.s 99.0 Weakly correlated
130 MLT1J2 2 n.s 99.0 Weakly correlated
131 MLT2F 2 * 99.0 Weakly correlated
132 MSTB 2 n.s 43.0 Weakly correlated
133 MamGypLTR2c 2 ** 99.0 Weakly correlated
134 THE1D 2 n.s 43.0 Weakly correlated
135 THE1D-int 2 n.s 28.9 Weakly correlated
136 Alu 1 * 74.0 Moderately correlated
137 AluSc5 1 n.s 74.0 Moderately correlated
138 AluSx4 1 n.s 74.0 Moderately correlated
139 AluYc3 1 ** 74.0 Moderately correlated
140 AluYh3a3 1 ** 15.2 Weakly correlated
141 AluYh9 1 **** 15.2 Weakly correlated
142 AluYk2 1 * 19.6 Weakly correlated
143 ERV3-16A3_LTR 1 * 99.0 Weakly correlated
144 ERVL-B4-int 1 n.s 99.0 Weakly correlated
145 ERVL-E-int 1 n.s 99.0 Weakly correlated
146 HERV3-int 1 n.s 28.9 Weakly correlated
147 HERV4_I-int 1 * 43.0 Weakly correlated
148 HERV9NC-int 1 n.s 19.6 Weakly correlated
149 HERVFH21-int 1 ** 28.9 Weakly correlated
150 HERVK14-int 1 * 28.9 Weakly correlated
151 HERVL18-int 1 n.s 43.0 Weakly correlated
152 HERVS71-int 1 n.s 28.9 Weakly correlated
153 Harlequin-int 1 n.s 74.0 Moderately correlated
154 L1M1 1 n.s 74.0 Moderately correlated
155 L1M2c 1 * 87.0 Weakly correlated
156 L1M3f 1 n.s 87.0 Weakly correlated
157 L1M4a2 1 n.s 99.0 Weakly correlated
158 L1MA10 1 n.s 99.0 Weakly correlated
159 L1MA5 1 n.s 87.0 Weakly correlated
160 L1MB1 1 n.s 99.0 Weakly correlated
161 L1MB5 1 n.s 99.0 Weakly correlated
162 L1MC 1 n.s 99.0 Weakly correlated
163 L1MC2 1 n.s 99.0 Weakly correlated
164 L1MC4a 1 n.s 99.0 Weakly correlated
165 L1MC5 1 n.s 99.0 Weakly correlated
166 L1MC5a 1 n.s 99.0 Weakly correlated
167 L1MDa 1 n.s 99.0 Weakly correlated
168 L1ME2 1 n.s 99.0 Weakly correlated
169 L1ME3B 1 n.s 99.0 Weakly correlated
170 L1ME3G 1 n.s 99.0 Weakly correlated
171 L1ME4a 1 n.s 99.0 Weakly correlated
172 L1MEg 1 n.s 99.0 Weakly correlated
173 L1PA12 1 n.s 74.0 Moderately correlated
174 L1PA16 1 n.s 74.0 Moderately correlated
175 L1PB1 1 n.s 74.0 Moderately correlated
176 L1PBa 1 n.s 74.0 Moderately correlated
177 L2-3_Crp 1 n.s 431.0 Weakly correlated
178 L4_A_Mam 1 n.s 99.0 Weakly correlated
179 L4_B_Mam 1 n.s 99.0 Weakly correlated
180 LFSINE_Vert 1 * 319.0 Weakly correlated
181 LTR101_Mam 1 * 99.0 Weakly correlated
182 LTR12B 1 * 28.9 Weakly correlated
183 LTR16 1 n.s 99.0 Weakly correlated
184 LTR16A2 1 n.s 99.0 Weakly correlated
185 LTR18C 1 *** 43.0 Weakly correlated
186 LTR19B 1 ** 43.0 Weakly correlated
187 LTR2 1 n.s 28.9 Weakly correlated
188 LTR32 1 * 43.0 Weakly correlated
189 LTR36 1 * 74.0 Moderately correlated
190 LTR37-int 1 n.s 99.0 Weakly correlated
191 LTR42 1 ** 74.0 Moderately correlated
192 LTR45B 1 ** 74.0 Moderately correlated
193 LTR49-int 1 n.s 74.0 Moderately correlated
194 LTR51 1 * 74.0 Moderately correlated
195 LTR54B 1 * 74.0 Moderately correlated
196 LTR5B 1 n.s 28.9 Weakly correlated
197 LTR61 1 ** 43.0 Weakly correlated
198 LTR69 1 ** 99.0 Weakly correlated
199 LTR78 1 n.s 99.0 Weakly correlated
200 LTR78B 1 n.s 99.0 Weakly correlated
201 LTR7B 1 * 28.9 Weakly correlated
202 LTR8A 1 n.s 43.0 Weakly correlated
203 LTR9B 1 * 43.0 Weakly correlated
204 MER11A 1 n.s 28.9 Weakly correlated
205 MER21A 1 n.s 74.0 Moderately correlated
206 MER21C 1 n.s 99.0 Weakly correlated
207 MER31A 1 n.s 87.0 Weakly correlated
208 MER31B 1 n.s 99.0 Weakly correlated
209 MER34A1 1 * 99.0 Weakly correlated
210 MER39B 1 n.s 74.0 Moderately correlated
211 MER4-int 1 n.s 74.0 Moderately correlated
212 MER41-int 1 n.s 74.0 Moderately correlated
213 MER49 1 n.s 43.0 Weakly correlated
214 MER4B 1 n.s 74.0 Moderately correlated
215 MER4D 1 n.s 74.0 Moderately correlated
216 MER4D0 1 * 74.0 Moderately correlated
217 MER50B 1 * 43.0 Weakly correlated
218 MER52C 1 * 74.0 Moderately correlated
219 MER57E1 1 ** 87.0 Weakly correlated
220 MER67D 1 * 99.0 Weakly correlated
221 MER89 1 n.s 99.0 Weakly correlated
222 MER9a2 1 ** 19.6 Weakly correlated
223 MLT1E 1 * 99.0 Weakly correlated
224 MLT1E1 1 * 99.0 Weakly correlated
225 MLT1E1A 1 n.s 99.0 Weakly correlated
226 MLT1F1 1 n.s 99.0 Weakly correlated
227 MLT1G3-int 1 ** 99.0 Weakly correlated
228 MLT1H 1 n.s 99.0 Weakly correlated
229 MLT1H2 1 n.s 99.0 Weakly correlated
230 MLT1I 1 n.s 99.0 Weakly correlated
231 MLT1I-int 1 * 99.0 Weakly correlated
232 MLT1K 1 n.s 99.0 Weakly correlated
233 MLT1L 1 n.s 99.0 Weakly correlated
234 MLT1M 1 * 99.0 Weakly correlated
235 MLT1N2 1 n.s 99.0 Weakly correlated
236 MLT1O 1 n.s 99.0 Weakly correlated
237 MLT2A2 1 n.s 74.0 Moderately correlated
238 MamGypLTR3a 1 * 99.0 Weakly correlated
239 MamGypsy2-I 1 n.s 99.0 Weakly correlated
240 MamRTE1 1 n.s 99.0 Weakly correlated
241 MamRep1527 1 * 99.0 Weakly correlated
242 Plat_L3 1 n.s 99.0 Weakly correlated
243 SVA_B 1 n.s 15.2 Weakly correlated
244 SVA_C 1 n.s 15.2 Weakly correlated
245 SVA_D 1 n.s 15.2 Weakly correlated
246 THE1C-int 1 n.s 43.0 Weakly correlated
247 X6B_LINE 1 ** 99.0 Weakly correlated
248 X7B_LINE 1 ** 319.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1PA7 405 **** 74.0 Moderately correlated
2 MLT2B4 142 **** 99.0 Weakly correlated
3 L1P3 109 **** 74.0 Moderately correlated
4 L1PA3 84 **** 19.6 Weakly correlated
5 L1PA8 44 **** 74.0 Moderately correlated
6 L1PA4 32 ** 19.6 Weakly correlated
7 MLT2B1 26 **** 99.0 Weakly correlated
8 L1P2 25 **** 28.9 Weakly correlated
9 L1PA2 18 ** 15.2 Weakly correlated
10 L1PA5 17 n.s 19.6 Weakly correlated
11 MLT2D 9 **** 99.0 Weakly correlated
12 L1P1 8 ** 19.6 Weakly correlated
13 L1PA6 6 n.s 28.9 Weakly correlated
14 LTR18B 6 **** 43.0 Weakly correlated
15 HERVK-int 4 *** 28.9 Weakly correlated
16 L2a 4 n.s 99.0 Weakly correlated
17 L1PA10 4 n.s 74.0 Moderately correlated
18 L1MB8 4 n.s 99.0 Weakly correlated
19 L1PA13 4 n.s 74.0 Moderately correlated
20 L1MB7 3 n.s 99.0 Weakly correlated
21 MLT2C2 3 *** 99.0 Weakly correlated
22 L1PA11 3 n.s 74.0 Moderately correlated
23 L1MA4 2 n.s 87.0 Weakly correlated
24 L1HS 2 n.s 8.6 Weakly correlated
25 L1MA5A 2 n.s 87.0 Weakly correlated
26 L2b 2 n.s 99.0 Weakly correlated
27 MIRb 2 n.s 99.0 Weakly correlated
28 SVA_C 1 n.s 15.2 Weakly correlated
29 MLT1F 1 n.s 99.0 Weakly correlated
30 L1MEd 1 n.s 99.0 Weakly correlated
31 AluJb 1 n.s 74.0 Moderately correlated
32 MLT2B2 1 n.s 99.0 Weakly correlated
33 LTR10A 1 ** 28.9 Weakly correlated
34 LTR12C 1 n.s 19.6 Weakly correlated
35 MER57E1 1 ** 87.0 Weakly correlated
36 MLT1A 1 n.s 99.0 Weakly correlated
37 L1PA8A 1 n.s 74.0 Moderately correlated
38 MLT1E 1 * 99.0 Weakly correlated
39 L1PREC2 1 n.s 43.0 Weakly correlated
40 L1MA6 1 n.s 87.0 Weakly correlated
41 L1MC4 1 n.s 99.0 Weakly correlated
42 L3 1 n.s 99.0 Weakly correlated
43 MER31B 1 n.s 99.0 Weakly correlated
44 MLT1F1 1 n.s 99.0 Weakly correlated
45 L1M5 1 n.s 99.0 Weakly correlated
46 MIRc 1 n.s 99.0 Weakly correlated
47 MSTA 1 n.s 43.0 Weakly correlated
48 AluSz 1 n.s 74.0 Moderately correlated
49 L1MEi 1 n.s 99.0 Weakly correlated
50 MIR3 1 n.s 99.0 Weakly correlated
51 MLT1D 1 n.s 99.0 Weakly correlated
52 HERV9NC-int 1 n.s 19.6 Weakly correlated
53 L2 1 n.s 99.0 Weakly correlated
54 LTR54B 1 * 74.0 Moderately correlated
55 LTR69 1 ** 99.0 Weakly correlated
56 MLT1C 1 n.s 94.0 Weakly correlated
57 L1M4 1 n.s 99.0 Weakly correlated
58 L1M4c 1 n.s 99.0 Weakly correlated
59 MER50B 1 * 43.0 Weakly correlated
60 MER52C 1 * 74.0 Moderately correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP
1 LTR18B 43.0 Weakly correlated