ZRdb KZFP & Repeats
...

Human_ZNF157

  • Protein
    Zinc finger protein 157
  • Length
    506
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    99.0 Mya
  • Uniprot_ID
    P51786
  • NCBI_ID
    7712
Sequence:
MPANGTSPQRFPALIPGEPGRSFEGSVSFEDVAVDFTRQEWHRLDPAQRTMHKDVMLETYSNLASVGLCVAKPEMIFKLERGEELWILEEESSGHGYSGSLSLLCGNGSVGDNALRHDNDLLHHQKIQTLDQNVEYNGCRKAFHEKTGFVRRKRTPRGDKNFECHECGKAYCRKSNLVEHLRIHTGERPYECGECAKTFSARSYLIAHQKTHTGERPFECNECGKSFGRKSQLILHTRTHTGERPYECTECGKTFSEKATLTIHQRTHTGEKPYECSECGKTFRVKISLTQHHRTHTGEKPYECGECGKNFRAKKSLNQHQRIHTGEKPYECGECGKFFRMKMTLNNHQRTHTGEKPYQCNECGKSFRVHSSLGIHQRIHTGEKPYECNECGNAFYVKARLIEHQRMHSGEKPYECSECGKIFSMKKSLCQHRRTHTGEKPYECSECGNAFYVKVRLIEHQRIHTGERPFECQECGKAFCRKAHLTEHQRTHIGWSWRCTMKKASH
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
...
# Domain name Pos
1 KRAB 27..98
2 C2h2 162..184
3 C2h2 190..212
4 C2h2 218..240
5 C2h2 246..268
6 C2h2 274..296
7 C2h2 302..324
8 C2h2 330..352
9 C2h2 358..380
10 C2h2 386..408
11 C2h2 414..436
12 C2h2 442..464
13 C2h2 470..492
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
...
Reverse:
...
Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 HERVL-int 202 **** 74.0 Weakly correlated
2 ERVL-E-int 88 **** 99.0 Highly correlated
3 ERVL-B4-int 69 **** 99.0 Highly correlated
4 MIRb 31 ** 99.0 Highly correlated
5 MLT1B 31 **** 99.0 Highly correlated
6 L2c 22 * 99.0 Highly correlated
7 L2b 19 ** 99.0 Highly correlated
8 MIR 16 n.s 99.0 Highly correlated
9 ERVL-int 15 **** 99.0 Highly correlated
10 ERV3-16A3_I-int 14 **** 99.0 Highly correlated
11 L2a 12 n.s 99.0 Highly correlated
12 AluSx1 11 n.s 74.0 Weakly correlated
13 AluJb 10 n.s 74.0 Weakly correlated
14 AluJo 10 n.s 74.0 Weakly correlated
15 AluJr 10 n.s 74.0 Weakly correlated
16 MIR3 10 * 99.0 Highly correlated
17 AluSx 9 n.s 74.0 Weakly correlated
18 AluY 9 n.s 74.0 Weakly correlated
19 MLT1C 9 ** 94.0 Weakly correlated
20 L1PA4 7 n.s 19.6 Weakly correlated
21 AluSc 6 n.s 74.0 Weakly correlated
22 AluSp 6 n.s 74.0 Weakly correlated
23 MIRc 6 n.s 99.0 Highly correlated
24 AluSz 5 n.s 74.0 Weakly correlated
25 L1PA2 5 n.s 15.2 Weakly correlated
26 L2 5 n.s 99.0 Highly correlated
27 LTR12C 5 * 19.6 Weakly correlated
28 ERV24B_Prim-int 4 **** 74.0 Weakly correlated
29 HERV16-int 4 **** 99.0 Highly correlated
30 L1ME4b 4 n.s 99.0 Highly correlated
31 L1PA10 4 n.s 74.0 Weakly correlated
32 L1PA13 4 n.s 74.0 Weakly correlated
33 L1PA5 4 n.s 19.6 Weakly correlated
34 L3 4 n.s 99.0 Highly correlated
35 LTR10A 4 **** 28.9 Weakly correlated
36 AluSc8 3 n.s 74.0 Weakly correlated
37 AluSg 3 n.s 74.0 Weakly correlated
38 AluSq2 3 n.s 74.0 Weakly correlated
39 L1P3 3 n.s 74.0 Weakly correlated
40 LTR16C 3 * 99.0 Highly correlated
41 MER50 3 ** 43.0 Weakly correlated
42 MLT1H 3 n.s 99.0 Highly correlated
43 PRIMA4-int 3 **** 74.0 Weakly correlated
44 THE1D-int 3 * 28.9 Weakly correlated
45 AluSg4 2 n.s 74.0 Weakly correlated
46 AluSq 2 n.s 74.0 Weakly correlated
47 AluSz6 2 n.s 74.0 Weakly correlated
48 AluYk4 2 *** 15.2 Weakly correlated
49 AluYm1 2 * 19.6 Weakly correlated
50 ERV3-16A3_LTR 2 *** 99.0 Highly correlated
51 FLAM_A 2 n.s 74.0 Weakly correlated
52 HERVL18-int 2 ** 43.0 Weakly correlated
53 HERVL40-int 2 ** 99.0 Highly correlated
54 L1M3c 2 ** 99.0 Highly correlated
55 L1M3f 2 ** 87.0 Weakly correlated
56 L1MA1 2 n.s 74.0 Weakly correlated
57 L1MA4A 2 n.s 87.0 Weakly correlated
58 L1MA9 2 n.s 99.0 Highly correlated
59 L1MC4 2 n.s 99.0 Highly correlated
60 L1MC4a 2 n.s 99.0 Highly correlated
61 L1MC5a 2 n.s 99.0 Highly correlated
62 L1MCa 2 n.s 99.0 Highly correlated
63 L1ME3 2 n.s 99.0 Highly correlated
64 L1ME3Cz 2 n.s 99.0 Highly correlated
65 L1MEg 2 n.s 99.0 Highly correlated
66 L1PA11 2 n.s 74.0 Weakly correlated
67 L1PA15 2 n.s 74.0 Weakly correlated
68 L1PA3 2 n.s 19.6 Weakly correlated
69 L1PA8 2 n.s 74.0 Weakly correlated
70 L1PREC2 2 n.s 43.0 Weakly correlated
71 LTR10D 2 **** 28.9 Weakly correlated
72 LTR17 2 ** 28.9 Weakly correlated
73 LTR33 2 n.s 99.0 Highly correlated
74 LTR33A 2 ** 99.0 Highly correlated
75 MER89-int 2 *** 99.0 Highly correlated
76 MIR1_Amn 2 * 319.0 Weakly correlated
77 MLT1D 2 n.s 99.0 Highly correlated
78 MLT1I 2 n.s 99.0 Highly correlated
79 MLT1K 2 n.s 99.0 Highly correlated
80 MLT1L 2 n.s 99.0 Highly correlated
81 MSTD 2 n.s 74.0 Weakly correlated
82 PRIMAX-int 2 **** 74.0 Weakly correlated
83 SVA_D 2 n.s 15.2 Weakly correlated
84 SVA_F 2 ** 0.0 Weakly correlated
85 THE1B 2 n.s 43.0 Weakly correlated
86 Alu 1 ** 74.0 Weakly correlated
87 AluJr4 1 n.s 74.0 Weakly correlated
88 AluSg7 1 n.s 74.0 Weakly correlated
89 AluSx3 1 n.s 74.0 Weakly correlated
90 AluSx4 1 n.s 74.0 Weakly correlated
91 AluYa5 1 n.s 15.2 Weakly correlated
92 AluYb9 1 ** 15.2 Weakly correlated
93 AluYe5 1 * 74.0 Weakly correlated
94 AluYh3 1 * 15.2 Weakly correlated
95 AluYh9 1 **** 15.2 Weakly correlated
96 AluYk3 1 * 19.6 Weakly correlated
97 CR1_Mam 1 * 99.0 Highly correlated
98 ERV24_Prim-int 1 ** 74.0 Weakly correlated
99 ERVL47-int 1 ** 74.0 Weakly correlated
100 FRAM 1 n.s 74.0 Weakly correlated
101 HAL1 1 n.s 99.0 Highly correlated
102 HERV17-int 1 n.s 28.9 Weakly correlated
103 HERVIP10B3-int 1 * 28.9 Weakly correlated
104 L1M1 1 n.s 74.0 Weakly correlated
105 L1M6 1 n.s 99.0 Highly correlated
106 L1MB3 1 n.s 99.0 Highly correlated
107 L1MB7 1 n.s 99.0 Highly correlated
108 L1MC 1 n.s 99.0 Highly correlated
109 L1MC3 1 n.s 99.0 Highly correlated
110 L1MD 1 n.s 99.0 Highly correlated
111 L1MD1 1 n.s 99.0 Highly correlated
112 L1MD2 1 n.s 99.0 Highly correlated
113 L1MD3 1 n.s 99.0 Highly correlated
114 L1ME3B 1 n.s 99.0 Highly correlated
115 L1ME3E 1 n.s 99.0 Highly correlated
116 L1ME4a 1 n.s 99.0 Highly correlated
117 L1MEd 1 n.s 99.0 Highly correlated
118 L1MEj 1 n.s 99.0 Highly correlated
119 L1P1 1 n.s 19.6 Weakly correlated
120 L1P2 1 n.s 28.9 Weakly correlated
121 L1PA12 1 n.s 74.0 Weakly correlated
122 L1PA16 1 n.s 74.0 Weakly correlated
123 L1PA6 1 n.s 28.9 Weakly correlated
124 L1PA7 1 n.s 74.0 Weakly correlated
125 L1PB 1 n.s 74.0 Weakly correlated
126 L1PB1 1 n.s 74.0 Weakly correlated
127 L1PBa1 1 n.s 74.0 Weakly correlated
128 L2-3_Crp 1 * 431.0 Weakly correlated
129 LTR13 1 * 19.6 Weakly correlated
130 LTR14B 1 ** 28.9 Weakly correlated
131 LTR16A 1 n.s 99.0 Highly correlated
132 LTR16A1 1 n.s 99.0 Highly correlated
133 LTR1A2 1 * 43.0 Weakly correlated
134 LTR2752 1 ** 43.0 Weakly correlated
135 LTR27E 1 ** 43.0 Weakly correlated
136 LTR28 1 ** 43.0 Weakly correlated
137 LTR28C 1 ** 43.0 Weakly correlated
138 LTR33B 1 * 99.0 Highly correlated
139 LTR41 1 * 99.0 Highly correlated
140 LTR50 1 n.s 99.0 Highly correlated
141 LTR52 1 * 99.0 Highly correlated
142 LTR52-int 1 *** 99.0 Highly correlated
143 LTR53-int 1 ** 99.0 Highly correlated
144 LTR56 1 * 74.0 Weakly correlated
145 LTR5_Hs 1 * 0.0 Weakly correlated
146 LTR67B 1 n.s 99.0 Highly correlated
147 LTR8B 1 n.s 43.0 Weakly correlated
148 LTR9C 1 *** 43.0 Weakly correlated
149 MER11A 1 n.s 28.9 Weakly correlated
150 MER39B 1 * 74.0 Weakly correlated
151 MER4-int 1 n.s 74.0 Weakly correlated
152 MER41B 1 n.s 74.0 Weakly correlated
153 MER57B1 1 * 43.0 Weakly correlated
154 MER61-int 1 n.s 43.0 Weakly correlated
155 MER61A 1 ** 43.0 Weakly correlated
156 MER9B 1 **** 28.9 Weakly correlated
157 MER9a2 1 ** 19.6 Weakly correlated
158 MLT1A1 1 n.s 87.0 Weakly correlated
159 MLT1D-int 1 * 99.0 Highly correlated
160 MLT1E3 1 * 99.0 Highly correlated
161 MLT1F 1 n.s 99.0 Highly correlated
162 MLT1F1 1 n.s 99.0 Highly correlated
163 MLT1G 1 n.s 99.0 Highly correlated
164 MLT1G1 1 n.s 99.0 Highly correlated
165 MLT1J 1 n.s 99.0 Highly correlated
166 MLT1J-int 1 * 99.0 Highly correlated
167 MLT1J2 1 n.s 99.0 Highly correlated
168 MLT1N2 1 n.s 99.0 Highly correlated
169 MLT1O 1 n.s 99.0 Highly correlated
170 MLT2A1 1 n.s 74.0 Weakly correlated
171 MLT2C1 1 * 99.0 Highly correlated
172 MLT2C2 1 * 99.0 Highly correlated
173 MLT2F 1 * 99.0 Highly correlated
174 MSTA 1 n.s 43.0 Weakly correlated
175 MSTA-int 1 n.s 43.0 Weakly correlated
176 MamGypLTR1c 1 ** 99.0 Highly correlated
177 MamGypLTR3 1 ** 99.0 Highly correlated
178 SVA_C 1 * 15.2 Weakly correlated
179 THE1B-int 1 n.s 43.0 Weakly correlated
180 THE1C 1 n.s 43.0 Weakly correlated
181 THE1C-int 1 n.s 43.0 Weakly correlated
182 THE1D 1 n.s 43.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 HERVL-int 203 **** 74.0 Weakly correlated
2 ERVL-E-int 76 **** 99.0 Highly correlated
3 ERVL-B4-int 65 **** 99.0 Highly correlated
4 ERVL-int 13 **** 99.0 Highly correlated
5 ERV3-16A3_I-int 5 * 99.0 Highly correlated
6 ERV24B_Prim-int 4 **** 74.0 Weakly correlated
7 L2c 4 n.s 99.0 Highly correlated
8 PRIMA4-int 3 **** 74.0 Weakly correlated
9 L2b 3 n.s 99.0 Highly correlated
10 L1PA10 2 n.s 74.0 Weakly correlated
11 MIR3 2 n.s 99.0 Highly correlated
12 MLT1B 2 n.s 99.0 Highly correlated
13 MIRb 2 n.s 99.0 Highly correlated
14 MER89-int 2 *** 99.0 Highly correlated
15 HERVL18-int 2 ** 43.0 Weakly correlated
16 HERV16-int 2 ** 99.0 Highly correlated
17 MLT1C 1 n.s 94.0 Weakly correlated
18 AluJr 1 n.s 74.0 Weakly correlated
19 L1P2 1 n.s 28.9 Weakly correlated
20 L1PA15 1 n.s 74.0 Weakly correlated
21 L1MA4A 1 n.s 87.0 Weakly correlated
22 MLT1K 1 n.s 99.0 Highly correlated
23 ERV24_Prim-int 1 ** 74.0 Weakly correlated
24 MER57B1 1 * 43.0 Weakly correlated
25 PRIMAX-int 1 **** 74.0 Weakly correlated
26 ERVL47-int 1 ** 74.0 Weakly correlated
27 MLT1J2 1 n.s 99.0 Highly correlated
28 MLT1E3 1 * 99.0 Highly correlated
29 L1PA4 1 n.s 19.6 Weakly correlated
30 MIR 1 n.s 99.0 Highly correlated
31 HERVL40-int 1 * 99.0 Highly correlated
32 LTR52-int 1 *** 99.0 Highly correlated
33 LTR33A 1 * 99.0 Highly correlated
34 LTR28 1 ** 43.0 Weakly correlated
35 L1ME3B 1 n.s 99.0 Highly correlated
36 L1PA2 1 n.s 15.2 Weakly correlated
37 L2 1 n.s 99.0 Highly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP
1 ERVL-B4-INT 99.0 Highly correlated
2 ERVL-E-INT 99.0 Highly correlated
3 ERVL-INT 99.0 Highly correlated
4 HERVL-INT 74.0 Weakly correlated