ZRdb KZFP & Repeats
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Human_ZNF154

  • Protein
    Zinc finger protein 154
  • Length
    437
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    94.0 Mya
  • Time of Changing in binding specificity
    94.0 Mya
  • Uniprot_ID
    Q13106
  • NCBI_ID
    7710
Sequence:
MAAATLRTPTQGTVTFEDVAVHFSWEEWGLLDEAQRCLYRDVMLENLALLTSLDVHHQKQHLGEKHFRSNVGRALFVKTCTFHVSGEPSTCREVGKDFLAKLGFLHQQAAHTGEQSNSKSDGGAISHRGKTHYNCGEHTKAFSGKHTLVQQQRTLTTERCYICSECGKSFSKSYSLNDHWRLHTGEKPYECRECGKSFRQSSSLIQHRRVHTAVRPHECDECGKLFSNKSNLIKHRRVHTGERPYECSECGKSFSQRSALLQHRGVHTGERPYECSECGKFFTYHSSLIKHQKVHSGSRPYECSECGKSFSQNSSLIEHHRVHTGERPYKCSECGKSFSQRSALLQHRGVHTGERPYECSECGKFFPYSSSLRKHQRVHTGSRPYECSECGKSFTQNSGLIKHRRVHTGEKPYECTECGKSFSHNSSLIKHQRIHSR
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 14..88
2 dec2h2 89..111
3 dec2h2 133..155
4 C2h2 161..183
5 C2h2 189..211
6 C2h2 217..239
7 C2h2 245..267
8 C2h2 273..295
9 C2h2 301..323
10 C2h2 329..351
11 C2h2 357..379
12 C2h2 385..407
13 C2h2 413..435
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1M4 50 **** 99.0 Moderately correlated
2 L1M4c 40 **** 99.0 Moderately correlated
3 HERVP71A-int 18 **** 43.0 Weakly correlated
4 L1MB7 16 **** 99.0 Moderately correlated
5 L1MB3 16 **** 99.0 Moderately correlated
6 L1MB4 14 **** 99.0 Moderately correlated
7 AluSx 5 n.s 74.0 Weakly correlated
8 L1MB5 4 *** 99.0 Moderately correlated
9 LTR10A 3 **** 28.9 Weakly correlated
10 AluSx1 3 n.s 74.0 Weakly correlated
11 AluSz 3 n.s 74.0 Weakly correlated
12 AluSc 2 n.s 74.0 Weakly correlated
13 L1P3 2 * 74.0 Weakly correlated
14 FLAM_C 2 * 74.0 Weakly correlated
15 L1PA3 1 n.s 19.6 Weakly correlated
16 L2 1 n.s 99.0 Moderately correlated
17 L1PA5 1 n.s 19.6 Weakly correlated
18 L1MEc 1 n.s 99.0 Moderately correlated
19 L1PA14 1 n.s 74.0 Weakly correlated
20 L1P4 1 * 74.0 Weakly correlated
21 L1P1 1 n.s 19.6 Weakly correlated
22 L1MEf 1 n.s 99.0 Moderately correlated
23 L1MB8 1 n.s 99.0 Moderately correlated
24 L2a 1 n.s 99.0 Moderately correlated
25 LTR16C 1 * 99.0 Moderately correlated
26 LTR19C 1 **** 43.0 Weakly correlated
27 LTR6A 1 *** 28.9 Weakly correlated
28 MER39B 1 ** 74.0 Weakly correlated
29 MER68 1 ** 99.0 Moderately correlated
30 MIR 1 n.s 99.0 Moderately correlated
31 MIR3 1 n.s 99.0 Moderately correlated
32 MIRb 1 n.s 99.0 Moderately correlated
33 MLT1D 1 n.s 99.0 Moderately correlated
34 MLT1J 1 n.s 99.0 Moderately correlated
35 SVA_A 1 ** 19.6 Weakly correlated
36 SVA_D 1 * 15.2 Weakly correlated
37 FLAM_A 1 * 74.0 Weakly correlated
38 AluJo 1 n.s 74.0 Weakly correlated
39 AluJr4 1 n.s 74.0 Weakly correlated
40 AluSc8 1 n.s 74.0 Weakly correlated
41 AluSp 1 n.s 74.0 Weakly correlated
42 AluSq10 1 ** 74.0 Weakly correlated
43 AluSq2 1 n.s 74.0 Weakly correlated
44 AluSz6 1 n.s 74.0 Weakly correlated
45 AluY 1 n.s 74.0 Weakly correlated
46 AluYa5 1 * 15.2 Weakly correlated
47 AluYe5 1 ** 74.0 Weakly correlated
48 AluYh3 1 ** 15.2 Weakly correlated
49 L1ME3F 1 * 99.0 Moderately correlated
50 HAL1 1 n.s 99.0 Moderately correlated
51 L1M2a 1 ** 87.0 Weakly correlated
52 L1MA8 1 n.s 87.0 Weakly correlated
53 L1MB2 1 n.s 99.0 Moderately correlated
54 AluJb 1 n.s 74.0 Weakly correlated
55 L1MC5a 1 n.s 99.0 Moderately correlated
56 L1MD 1 n.s 99.0 Moderately correlated
57 L1ME1 1 n.s 99.0 Moderately correlated
58 L1ME2 1 n.s 99.0 Moderately correlated
59 L1ME3 1 n.s 99.0 Moderately correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1M4 47 **** 99.0 Moderately correlated
2 L1M4c 38 **** 99.0 Moderately correlated
3 HERVP71A-int 18 **** 43.0 Weakly correlated
4 L1MB3 15 **** 99.0 Moderately correlated
5 L1MB7 15 **** 99.0 Moderately correlated
6 L1MB4 13 **** 99.0 Moderately correlated
7 L1MB5 4 *** 99.0 Moderately correlated
8 L1ME2 1 n.s 99.0 Moderately correlated
9 L2a 1 n.s 99.0 Moderately correlated
10 SVA_D 1 * 15.2 Weakly correlated
11 MLT1J 1 n.s 99.0 Moderately correlated
12 AluSp 1 n.s 74.0 Weakly correlated
13 SVA_A 1 ** 19.6 Weakly correlated
14 MIR 1 n.s 99.0 Moderately correlated
15 LTR6A 1 *** 28.9 Weakly correlated
16 L1PA3 1 n.s 19.6 Weakly correlated
17 L1PA14 1 n.s 74.0 Weakly correlated
18 L1MEf 1 n.s 99.0 Moderately correlated
19 L1ME3F 1 * 99.0 Moderately correlated
20 L1ME3 1 n.s 99.0 Moderately correlated
21 L1ME1 1 n.s 99.0 Moderately correlated
22 L1MC5a 1 n.s 99.0 Moderately correlated
23 L1MB8 1 n.s 99.0 Moderately correlated
24 L1MB2 1 n.s 99.0 Moderately correlated
25 L1M2a 1 ** 87.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP