ZRdb KZFP & Repeats
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Human_ZNF14

  • Protein
    Zinc finger protein 14
  • Length
    642
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    74.0 Mya
  • Time of Changing in binding specificity
    69.0 Mya
  • Uniprot_ID
    P17017
  • NCBI_ID
    7561
Sequence:
MDSVSFEDVAVNFTLEEWALLDSSQKKLYEDVMQETFKNLVCLGKKWEDQDIEDDHRNQGKNRRCHMVERLCESRRGSKCGETTSQMPNVNINKETFTGAKPHECSFCGRDFIHHSSLNRHMRSHTGQKPNEYQEYEKQPCKCKAVGKTFSYHHCFRKHERTHTGVKPYECKQCGKAFIYYQPFQRHERTHAGQKPYECKQCGKTFIYYQSFQKHAHTGKKPYECKQCGKAFICYQSFQRHKRTHTGEKPYECKQCGKAFSCPTYFRTHERTHTGEKPYKCKECGKAFSFLSSFRRHKRTHSGEKPYECKECGKAFFYSASFRAHVIIHTGARPYKCKECGKAFNSSNSCRVHERTHIGEKPYECKRCGKSFSWSISLRLHERTHTGEKPYECKQCHKTFSFSSSLREHETTHTGEKPYECKQCGKTFSFSSSLQRHERTHNAEKPYECKQCGKAFRCSSYFRIHERSHTGEKPYECKQCGKVFIRSSSFRLHERTHTGEKPYECKLCGKTFSFSSSLREHEKIHTGNKPFECKQCGKAFLRSSQIRLHERTHTGEKPYQCKQCGKAFISSSKFRMHERTHTGEKPYRCKQCGKAFRFSSSVRIHERSHTGEKPYECKQCGKAFISSSHFRLHERTHMGEKV
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 4..76
2 C2h2 103..125
3 dec2h2 141..163
4 C2h2 169..191
5 C2h2 197..217
6 C2h2 223..245
7 C2h2 251..273
8 C2h2 279..301
9 C2h2 307..329
10 C2h2 335..357
11 C2h2 363..385
12 C2h2 391..413
13 C2h2 419..441
14 C2h2 447..469
15 C2h2 475..497
16 C2h2 503..525
17 C2h2 531..553
18 C2h2 559..581
19 C2h2 587..609
20 C2h2 615..637
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II transcription regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 SVA_F 15 **** 0.0 Weakly correlated
2 SVA_D 7 **** 15.2 Weakly correlated
3 SVA_E 5 **** 0.0 Weakly correlated
4 MER21B 5 **** 99.0 Weakly correlated
5 L1PA5 4 n.s 19.6 Weakly correlated
6 LTR10A 4 **** 28.9 Weakly correlated
7 L2c 4 n.s 99.0 Weakly correlated
8 LTR10F 3 **** 28.9 Weakly correlated
9 AluY 3 n.s 74.0 Moderately correlated
10 AluJb 3 n.s 74.0 Moderately correlated
11 AluSc8 2 n.s 74.0 Moderately correlated
12 L1MB3 2 n.s 99.0 Weakly correlated
13 MIRc 2 n.s 99.0 Weakly correlated
14 LTR49-int 2 ** 74.0 Moderately correlated
15 LTR10B1 2 **** 28.9 Weakly correlated
16 L1MB8 2 n.s 99.0 Weakly correlated
17 L1PA4 1 n.s 19.6 Weakly correlated
18 L1M4 1 n.s 99.0 Weakly correlated
19 L1PA2 1 n.s 15.2 Weakly correlated
20 L1PA13 1 n.s 74.0 Moderately correlated
21 L1PA10 1 n.s 74.0 Moderately correlated
22 LTR12C 1 n.s 19.6 Weakly correlated
23 LTR2752 1 ** 43.0 Weakly correlated
24 L1P4 1 n.s 74.0 Moderately correlated
25 LTR5_Hs 1 * 0.0 Weakly correlated
26 AluSz6 1 n.s 74.0 Moderately correlated
27 MER57A-int 1 * 43.0 Weakly correlated
28 L1MC4 1 n.s 99.0 Weakly correlated
29 MLT1L 1 n.s 99.0 Weakly correlated
30 AluSz 1 n.s 74.0 Moderately correlated
31 AluSx 1 n.s 74.0 Moderately correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 SVA_E 1 ** 0.0 Weakly correlated
2 SVA_D 1 n.s 15.2 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP