ZRdb KZFP & Repeats
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Human_ZNF135

  • Protein
    Zinc finger protein 135
  • Length
    658
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    94.0 Mya
  • Time of Changing in binding specificity
    94.0 Mya
  • Uniprot_ID
    P52742
  • NCBI_ID
    7694
Sequence:
MTPGVRVSTDPEQVTFEDVVVGFSQEEWGQLKPAQRTLYRDVMLDTFRLLVSVGHWLPKPNVISLLEQEAELWAVESRLPQGVYPDLETRPKVKLSVLKQGISEEISNSVILVERFLWDGLWYCRGEDTEGHWEWSCESLESLAVPVAFTPVKTPVLEQWQRNGFGENISLNPDLPHQPMTPERQSPHTWGTRGKREKPDLNVLQKTCVKEKPYKCQECGKAFSHSSALIEHHRTHTGERPYECHECLKGFRNSSALTKHQRIHTGEKPYKCTQCGRTFNQIAPLIQHQRTHTGEKPYECSECGKSFSFRSSFSQHERTHTGEKPYECSECGKAFRQSIHLTQHLRIHTGEKPYQCGECGKAFSHSSSLTKHQRIHTGEKPYECHECGKAFTQITPLIQHQRTHTGEKPYECGECGKAFSQSTLLTEHRRIHTGEKPYGCNECGKTFSHSSSLSQHERTHTGEKPYECSQCGKAFRQSTHLTQHQRIHTGEKPYECNDCGKAFSHSSSLTKHQRIHTGEKPYECNQCGRAFSQLAPLIQHQRIHTGEKPYECNQCGRAFSQSSLLIEHQRIHTKEKPYGCNECGKSFSHSSSLSQHERTHTGEKPYECHDCGKSFRQSTHLTQHRRIHTGEKPYACRDCGKAFTHSSSLTKHQRTHTG
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 14..85
2 C2h2 214..236
3 C2h2 242..264
4 C2h2 270..292
5 C2h2 298..320
6 C2h2 326..348
7 C2h2 354..376
8 C2h2 382..404
9 C2h2 410..432
10 C2h2 438..460
11 C2h2 466..488
12 C2h2 494..516
13 C2h2 522..544
14 C2h2 550..572
15 C2h2 578..600
16 C2h2 606..628
17 C2h2 634..656
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process cytoskeleton organization
6 Biological Process regulation of cell morphogenesis
7 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 AluJb 689 **** 74.0 Weakly correlated
2 AluJo 183 **** 74.0 Weakly correlated
3 AluJr 162 **** 74.0 Weakly correlated
4 AluSx1 46 **** 74.0 Weakly correlated
5 AluSz 41 **** 74.0 Weakly correlated
6 MamRep605 38 **** 99.0 Moderately correlated
7 AluSx 35 ** 74.0 Weakly correlated
8 MLT1K 21 **** 99.0 Moderately correlated
9 AluY 19 n.s 74.0 Weakly correlated
10 L2a 19 n.s 99.0 Moderately correlated
11 AluSz6 17 ** 74.0 Weakly correlated
12 AluJr4 15 **** 74.0 Weakly correlated
13 AluSx3 15 *** 74.0 Weakly correlated
14 MIRb 15 n.s 99.0 Moderately correlated
15 AluSc 13 ** 74.0 Weakly correlated
16 FLAM_C 12 **** 74.0 Weakly correlated
17 MIR 12 n.s 99.0 Moderately correlated
18 AluSq2 11 n.s 74.0 Weakly correlated
19 AluSp 10 n.s 74.0 Weakly correlated
20 MIRc 10 n.s 99.0 Moderately correlated
21 L1M4 9 n.s 99.0 Moderately correlated
22 L2c 9 n.s 99.0 Moderately correlated
23 AluSc8 8 * 74.0 Weakly correlated
24 FRAM 8 **** 74.0 Weakly correlated
25 AluSq 7 * 74.0 Weakly correlated
26 AluSg 6 n.s 74.0 Weakly correlated
27 L1M2 5 n.s 99.0 Moderately correlated
28 L1M3 5 ** 99.0 Moderately correlated
29 L1M5 5 n.s 99.0 Moderately correlated
30 L1MA4 5 n.s 87.0 Weakly correlated
31 MIR3 5 n.s 99.0 Moderately correlated
32 L1MA5 4 * 87.0 Weakly correlated
33 L1MB3 4 n.s 99.0 Moderately correlated
34 L1MC4 4 n.s 99.0 Moderately correlated
35 L2 4 n.s 99.0 Moderately correlated
36 AluSc5 3 * 74.0 Weakly correlated
37 AluYf1 3 *** 19.6 Weakly correlated
38 HAL1b 3 * 99.0 Moderately correlated
39 L1MA3 3 n.s 74.0 Weakly correlated
40 L1MA4A 3 n.s 87.0 Weakly correlated
41 L1MA7 3 n.s 87.0 Weakly correlated
42 L1MA9 3 n.s 99.0 Moderately correlated
43 L1MB5 3 n.s 99.0 Moderately correlated
44 L1MB7 3 n.s 99.0 Moderately correlated
45 L1MC5 3 n.s 99.0 Moderately correlated
46 L1ME1 3 n.s 99.0 Moderately correlated
47 L1ME3 3 n.s 99.0 Moderately correlated
48 L1P3 3 n.s 74.0 Weakly correlated
49 L1PA16 3 n.s 74.0 Weakly correlated
50 L1PA2 3 n.s 15.2 Weakly correlated
51 L1PB4 3 n.s 99.0 Moderately correlated
52 L2b 3 n.s 99.0 Moderately correlated
53 L3 3 n.s 99.0 Moderately correlated
54 LTR10A 3 **** 28.9 Weakly correlated
55 MSTA 3 n.s 43.0 Weakly correlated
56 AluSg4 2 n.s 74.0 Weakly correlated
57 AluSg7 2 n.s 74.0 Weakly correlated
58 AluYj4 2 * 0.0 Weakly correlated
59 AluYm1 2 n.s 19.6 Weakly correlated
60 FLAM_A 2 n.s 74.0 Weakly correlated
61 HAL1ME 2 n.s 99.0 Moderately correlated
62 L1M1 2 n.s 74.0 Weakly correlated
63 L1M4c 2 n.s 99.0 Moderately correlated
64 L1MA5A 2 n.s 87.0 Weakly correlated
65 L1MB4 2 n.s 99.0 Moderately correlated
66 L1ME2 2 n.s 99.0 Moderately correlated
67 L1ME3G 2 n.s 99.0 Moderately correlated
68 L1ME4a 2 n.s 99.0 Moderately correlated
69 L1MEc 2 n.s 99.0 Moderately correlated
70 L1MEf 2 n.s 99.0 Moderately correlated
71 L1MEg 2 n.s 99.0 Moderately correlated
72 L1PA5 2 n.s 19.6 Weakly correlated
73 L1PB3 2 n.s 74.0 Weakly correlated
74 LTR2C 2 **** 19.6 Weakly correlated
75 MER68-int 2 *** 99.0 Moderately correlated
76 MLT1A0 2 n.s 99.0 Moderately correlated
77 MLT1D 2 n.s 99.0 Moderately correlated
78 MLT2D 2 * 99.0 Moderately correlated
79 THE1C-int 2 n.s 43.0 Weakly correlated
80 Alu 1 * 74.0 Weakly correlated
81 AluSq10 1 * 74.0 Weakly correlated
82 AluYc 1 n.s 74.0 Weakly correlated
83 AluYc3 1 ** 74.0 Weakly correlated
84 FAM 1 n.s 87.0 Weakly correlated
85 HAL1 1 n.s 99.0 Moderately correlated
86 HERV3-int 1 * 28.9 Weakly correlated
87 HERVK-int 1 * 28.9 Weakly correlated
88 HUERS-P3-int 1 n.s 43.0 Weakly correlated
89 Harlequin-int 1 n.s 74.0 Weakly correlated
90 L1M 1 ** 74.0 Weakly correlated
91 L1M2a 1 * 87.0 Weakly correlated
92 L1M3f 1 n.s 87.0 Weakly correlated
93 L1M6 1 n.s 99.0 Moderately correlated
94 L1M8 1 n.s 99.0 Moderately correlated
95 L1MA6 1 n.s 87.0 Weakly correlated
96 L1MA8 1 n.s 87.0 Weakly correlated
97 L1MB2 1 n.s 99.0 Moderately correlated
98 L1MB8 1 n.s 99.0 Moderately correlated
99 L1MC 1 n.s 99.0 Moderately correlated
100 L1MC3 1 n.s 99.0 Moderately correlated
101 L1MC5a 1 n.s 99.0 Moderately correlated
102 L1MCa 1 n.s 99.0 Moderately correlated
103 L1MCc 1 n.s 99.0 Moderately correlated
104 L1MD 1 n.s 99.0 Moderately correlated
105 L1MD2 1 n.s 99.0 Moderately correlated
106 L1ME2z 1 n.s 99.0 Moderately correlated
107 L1ME3A 1 n.s 99.0 Moderately correlated
108 L1ME3C 1 n.s 99.0 Moderately correlated
109 L1ME3D 1 n.s 99.0 Moderately correlated
110 L1MEd 1 n.s 99.0 Moderately correlated
111 L1MEg1 1 * 99.0 Moderately correlated
112 L1MEi 1 n.s 99.0 Moderately correlated
113 L1P1 1 n.s 19.6 Weakly correlated
114 L1P4 1 n.s 74.0 Weakly correlated
115 L1PA15 1 n.s 74.0 Weakly correlated
116 L1PA17 1 n.s 74.0 Weakly correlated
117 L1PA6 1 n.s 28.9 Weakly correlated
118 L1PA8 1 n.s 74.0 Weakly correlated
119 L1PB1 1 n.s 74.0 Weakly correlated
120 L1PBa 1 n.s 74.0 Weakly correlated
121 L1PREC2 1 n.s 43.0 Weakly correlated
122 L3b 1 n.s 99.0 Moderately correlated
123 L4_A_Mam 1 n.s 99.0 Moderately correlated
124 L5 1 ** 99.0 Moderately correlated
125 LOR1-int 1 n.s 74.0 Weakly correlated
126 LTR13 1 * 19.6 Weakly correlated
127 LTR14B 1 ** 28.9 Weakly correlated
128 LTR1A2 1 * 43.0 Weakly correlated
129 LTR23 1 ** 74.0 Weakly correlated
130 LTR28B 1 ** 43.0 Weakly correlated
131 LTR42 1 ** 74.0 Weakly correlated
132 LTR49-int 1 n.s 74.0 Weakly correlated
133 LTR53-int 1 ** 99.0 Moderately correlated
134 LTR55 1 ** 99.0 Moderately correlated
135 LTR7 1 n.s 19.6 Weakly correlated
136 MER11B 1 * 19.6 Weakly correlated
137 MER21-int 1 * 99.0 Moderately correlated
138 MER21A 1 n.s 74.0 Weakly correlated
139 MER34A 1 * 99.0 Moderately correlated
140 MER39B 1 * 74.0 Weakly correlated
141 MER4-int 1 n.s 74.0 Weakly correlated
142 MER4D 1 * 74.0 Weakly correlated
143 MER50 1 n.s 43.0 Weakly correlated
144 MER50-int 1 * 43.0 Weakly correlated
145 MER51B 1 ** 43.0 Weakly correlated
146 MER51E 1 ** 43.0 Weakly correlated
147 MER57A-int 1 n.s 43.0 Weakly correlated
148 MER61A 1 * 43.0 Weakly correlated
149 MLT-int 1 ** 99.0 Moderately correlated
150 MLT1A 1 n.s 99.0 Moderately correlated
151 MLT1C 1 n.s 94.0 Highly correlated
152 MLT1E3 1 n.s 99.0 Moderately correlated
153 MLT1F 1 n.s 99.0 Moderately correlated
154 MLT1H2 1 n.s 99.0 Moderately correlated
155 MLT1J 1 n.s 99.0 Moderately correlated
156 MLT1J2 1 n.s 99.0 Moderately correlated
157 MLT1L 1 n.s 99.0 Moderately correlated
158 MLT1O 1 n.s 99.0 Moderately correlated
159 MLT2B4 1 n.s 99.0 Moderately correlated
160 MSTC 1 n.s 74.0 Weakly correlated
161 MSTD 1 n.s 74.0 Weakly correlated
162 MamGypLTR3 1 ** 99.0 Moderately correlated
163 SVA_C 1 * 15.2 Weakly correlated
164 THE1A-int 1 n.s 43.0 Weakly correlated
165 THE1B-int 1 n.s 43.0 Weakly correlated
166 THE1C 1 n.s 43.0 Weakly correlated
167 X7B_LINE 1 ** 319.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 AluJb 670 **** 74.0 Weakly correlated
2 AluJo 176 **** 74.0 Weakly correlated
3 AluJr 153 **** 74.0 Weakly correlated
4 AluSz 29 * 74.0 Weakly correlated
5 AluSx1 27 n.s 74.0 Weakly correlated
6 AluSx 17 n.s 74.0 Weakly correlated
7 AluJr4 14 **** 74.0 Weakly correlated
8 AluSz6 14 * 74.0 Weakly correlated
9 AluY 11 n.s 74.0 Weakly correlated
10 AluSx3 9 n.s 74.0 Weakly correlated
11 FRAM 8 **** 74.0 Weakly correlated
12 FLAM_C 8 *** 74.0 Weakly correlated
13 AluSq2 7 n.s 74.0 Weakly correlated
14 AluSc 7 n.s 74.0 Weakly correlated
15 AluSp 6 n.s 74.0 Weakly correlated
16 AluSq 4 n.s 74.0 Weakly correlated
17 AluSc8 4 n.s 74.0 Weakly correlated
18 AluSg 3 n.s 74.0 Weakly correlated
19 MamRep605 2 * 99.0 Moderately correlated
20 FLAM_A 2 n.s 74.0 Weakly correlated
21 AluYm1 2 n.s 19.6 Weakly correlated
22 MLT1A0 1 n.s 99.0 Moderately correlated
23 THE1A-int 1 n.s 43.0 Weakly correlated
24 MER51B 1 ** 43.0 Weakly correlated
25 THE1C-int 1 n.s 43.0 Weakly correlated
26 MIR3 1 n.s 99.0 Moderately correlated
27 L2 1 n.s 99.0 Moderately correlated
28 MIRc 1 n.s 99.0 Moderately correlated
29 L2c 1 n.s 99.0 Moderately correlated
30 AluYf1 1 n.s 19.6 Weakly correlated
31 MLT1K 1 n.s 99.0 Moderately correlated
32 MIR 1 n.s 99.0 Moderately correlated
33 L2a 1 n.s 99.0 Moderately correlated
34 L1PA2 1 n.s 15.2 Weakly correlated
35 FAM 1 n.s 87.0 Weakly correlated
36 AluYj4 1 n.s 0.0 Weakly correlated
37 AluYc3 1 ** 74.0 Weakly correlated
38 AluSg4 1 n.s 74.0 Weakly correlated
39 AluSc5 1 n.s 74.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP