ZRdb KZFP & Repeats
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Human_ZNF132

  • Protein
    Zinc finger protein 132
  • Length
    706
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    94.0 Mya
  • Uniprot_ID
    P52740
  • NCBI_ID
    7691
Sequence:
MALPSPQVLMGLPALLMGPAQHTSWPCGSAVPTLKSMVTFEDVAVYFSQEEWELLDAAQRHLYHSVMLENLELVTSLGSWHGVEGEGAHPKQNVSVEVLQVRIPNADPSTKKANSCDMCGPFLKDILHLAEHQGTQSEEKPYTCGACGRDFWLNANLHQHQKEHSGGKPFRWYKDRDALMKSSKVHLSENPFTCREGGKVILGSCDLLQLQAVDSGQKPYSNLGQLPEVCTTQKLFECSNCGKAFLKSSTLPNHLRTHSEEIPFTCPTGGNFLEEKSILGNKKFHTGEIPHVCKECGKAFSHSSKLRKHQKFHTEVKYYECIACGKTFNHKLTFVHHQRIHSGERPYECDECGKAFSNRSHLIRHEKVHTGERPFECLKCGRAFSQSSNFLRHQKVHTQVRPYECSQCGKSFSRSSALIQHWRVHTGERPYECSECGRAFNNNSNLAQHQKVHTGERPFECSECGRDFSQSSHLLRHQKVHTGERPFECCDCGKAFSNSSTLIQHQKVHTGQRPYECSECRKSFSRSSSLIQHWRIHTGEKPYECSECGKAFAHSSTLIEHWRVHTKERPYECNECGKFFSQNSILIKHQKVHTGEKPYKCSECGKFFSRKSSLICHWRVHTGERPYECSECGRAFSSNSHLVRHQRVHTQERPYECIQCGKAFSERSTLVRHQKVHTRERTYECSQCGKLFSHLCNLAQHKKIHT
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 38..121
2 dec2h2 114..136
3 C2h2 142..164
4 C2h2 236..258
5 C2h2 291..313
6 C2h2 319..341
7 C2h2 347..369
8 C2h2 375..397
9 C2h2 403..425
10 C2h2 431..453
11 C2h2 459..481
12 C2h2 487..509
13 C2h2 515..537
14 C2h2 543..565
15 C2h2 571..593
16 C2h2 599..621
17 C2h2 627..649
18 C2h2 655..677
19 C2h2 683..705
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 LTR16B1 39 **** 99.0 Moderately correlated
2 LTR16B2 14 **** 99.0 Moderately correlated
3 LTR16B 12 **** 99.0 Moderately correlated
4 LTR53-int 5 **** 99.0 Moderately correlated
5 LTR10A 4 **** 28.9 Weakly correlated
6 L2b 4 n.s 99.0 Moderately correlated
7 L2a 4 n.s 99.0 Moderately correlated
8 MLT1D 3 * 99.0 Moderately correlated
9 AluSx1 3 n.s 74.0 Weakly correlated
10 AluSz 3 n.s 74.0 Weakly correlated
11 L1P3 3 ** 74.0 Weakly correlated
12 AluJo 2 n.s 74.0 Weakly correlated
13 MLT1I 2 ** 99.0 Moderately correlated
14 L1PA5 2 n.s 19.6 Weakly correlated
15 L1MEi 2 ** 99.0 Moderately correlated
16 L1MCc 2 ** 99.0 Moderately correlated
17 AluSx3 2 n.s 74.0 Weakly correlated
18 L1MA5A 2 ** 87.0 Weakly correlated
19 AluJr 2 n.s 74.0 Weakly correlated
20 MIRc 1 n.s 99.0 Moderately correlated
21 AluSx 1 n.s 74.0 Weakly correlated
22 AluSc 1 n.s 74.0 Weakly correlated
23 LTR55 1 *** 99.0 Moderately correlated
24 LTR85c 1 *** 99.0 Moderately correlated
25 MER39B 1 ** 74.0 Weakly correlated
26 MER65C 1 *** 74.0 Weakly correlated
27 MIR 1 n.s 99.0 Moderately correlated
28 MIR3 1 n.s 99.0 Moderately correlated
29 AluYh9 1 **** 15.2 Weakly correlated
30 MLT1A0 1 n.s 99.0 Moderately correlated
31 MLT1E2 1 * 99.0 Moderately correlated
32 MLT1F1 1 * 99.0 Moderately correlated
33 AluJb 1 n.s 74.0 Weakly correlated
34 MLT1L 1 n.s 99.0 Moderately correlated
35 MSTC 1 * 74.0 Weakly correlated
36 L1MC5a 1 n.s 99.0 Moderately correlated
37 LTR16A1 1 ** 99.0 Moderately correlated
38 LTR16A 1 * 99.0 Moderately correlated
39 LTR13 1 ** 19.6 Weakly correlated
40 LTR12C 1 n.s 19.6 Weakly correlated
41 AluYj4 1 ** 0.0 Weakly correlated
42 L3 1 n.s 99.0 Moderately correlated
43 ERV3-16A3_I-int 1 n.s 99.0 Moderately correlated
44 FLAM_A 1 * 74.0 Weakly correlated
45 HAL1 1 n.s 99.0 Moderately correlated
46 L1PA4 1 n.s 19.6 Weakly correlated
47 L1PA2 1 n.s 15.2 Weakly correlated
48 L1P4 1 * 74.0 Weakly correlated
49 L1M1 1 n.s 74.0 Weakly correlated
50 L1P1 1 n.s 19.6 Weakly correlated
51 L1MD1 1 n.s 99.0 Moderately correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 LTR16B1 39 **** 99.0 Moderately correlated
2 LTR16B2 14 **** 99.0 Moderately correlated
3 LTR16B 12 **** 99.0 Moderately correlated
4 LTR53-int 5 **** 99.0 Moderately correlated
5 L2a 3 n.s 99.0 Moderately correlated
6 AluSx3 2 n.s 74.0 Weakly correlated
7 L1MA5A 2 ** 87.0 Weakly correlated
8 L2b 2 n.s 99.0 Moderately correlated
9 FLAM_A 1 * 74.0 Weakly correlated
10 LTR85c 1 *** 99.0 Moderately correlated
11 HAL1 1 n.s 99.0 Moderately correlated
12 L1PA5 1 n.s 19.6 Weakly correlated
13 L1MCc 1 * 99.0 Moderately correlated
14 MER65C 1 *** 74.0 Weakly correlated
15 AluYj4 1 ** 0.0 Weakly correlated
16 AluJb 1 n.s 74.0 Weakly correlated
17 MLT1I 1 n.s 99.0 Moderately correlated
18 AluJo 1 n.s 74.0 Weakly correlated
19 MLT1D 1 n.s 99.0 Moderately correlated
20 MIR 1 n.s 99.0 Moderately correlated
21 AluSx 1 n.s 74.0 Weakly correlated
22 LTR16A 1 * 99.0 Moderately correlated
23 L1MEi 1 * 99.0 Moderately correlated
24 L1M1 1 n.s 74.0 Weakly correlated
25 AluSz 1 n.s 74.0 Weakly correlated
26 AluSx1 1 n.s 74.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP
1 LTR16B 99.0 Moderately correlated
2 LTR16B1 99.0 Moderately correlated
3 LTR16B2 99.0 Moderately correlated