ZRdb KZFP & Repeats
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Human_ZNF124

  • Protein
    Zinc finger protein 124
  • Length
    351
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    43.0 Mya
  • Time of Changing in binding specificity
    43.0 Mya
  • Uniprot_ID
    Q15973
  • NCBI_ID
    7678
Sequence:
MSGHPGSWEMNSVAFEDVAVNFTQEEWALLDPSQKNLYRDVMQETFRNLASIGNKGEDQSIEDQYKNSSRNLRHIISHSGNNPYGCEECGKKPCTCKQCQKTSLSVTRVHRDTVMHTGNGHYGCTICEKVFNIPSSFQIHQRNHTGEKPYECMECGKALGFSRSLNRHKRIHTGEKRYECKQCGKAFSRSSHLRDHERTHTGEKPYECKHCGKAFRYSNCLHYHERTHTGEKPYVCMECGKAFSCLSSLQGHIKAHAGEEPYPCKQCGKAFRYASSLQKHEKTHIAQKPYVCNNCGKGFRCSSSLRDHERTHTGEKPYECQKCGKAFSRASTLWKHKKTHTGEKPYKCKKM
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 13..106
2 C2h2 122..144
3 C2h2 150..172
4 C2h2 178..200
5 C2h2 206..228
6 C2h2 234..256
7 C2h2 262..284
8 C2h2 290..312
9 C2h2 318..340
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA binding
3 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
4 Molecular Function DNA-binding transcription repressor activity, RNA polymerase II-specific
5 Molecular Function metal ion binding
6 Molecular Function RNA polymerase II transcription regulatory region sequence-specific DNA binding
7 Biological Process negative regulation of transcription by RNA polymerase II
8 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 LOR1b 219 **** 74.0 Weakly correlated
2 LOR1a 128 **** 74.0 Weakly correlated
3 LTR13 45 **** 19.6 Weakly correlated
4 AluJb 24 * 74.0 Weakly correlated
5 L1PA3 18 ** 19.6 Weakly correlated
6 LOR1-int 15 **** 74.0 Weakly correlated
7 AluSx 13 n.s 74.0 Weakly correlated
8 AluY 13 n.s 74.0 Weakly correlated
9 L1PA2 13 *** 15.2 Weakly correlated
10 LTR2 12 **** 28.9 Weakly correlated
11 LTR13_ 10 **** 28.9 Weakly correlated
12 AluSx1 8 n.s 74.0 Weakly correlated
13 AluSz 8 n.s 74.0 Weakly correlated
14 MIRb 8 n.s 99.0 Weakly correlated
15 AluJo 7 n.s 74.0 Weakly correlated
16 AluSq2 7 n.s 74.0 Weakly correlated
17 AluSz6 7 n.s 74.0 Weakly correlated
18 L2b 7 n.s 99.0 Weakly correlated
19 THE1C-int 7 **** 43.0 Highly correlated
20 AluSg 6 n.s 74.0 Weakly correlated
21 AluSp 6 n.s 74.0 Weakly correlated
22 HAL1 6 n.s 99.0 Weakly correlated
23 L1P3 6 *** 74.0 Weakly correlated
24 L1PA4 6 n.s 19.6 Weakly correlated
25 L2a 6 n.s 99.0 Weakly correlated
26 AluJr 5 n.s 74.0 Weakly correlated
27 LTR13A 5 **** 28.9 Weakly correlated
28 MSTA-int 5 ** 43.0 Highly correlated
29 L1PA5 4 n.s 19.6 Weakly correlated
30 LTR10A 4 **** 28.9 Weakly correlated
31 MER50 4 *** 43.0 Highly correlated
32 MIR 4 n.s 99.0 Weakly correlated
33 AluSc 3 n.s 74.0 Weakly correlated
34 FLAM_C 3 n.s 74.0 Weakly correlated
35 L1MA7 3 n.s 87.0 Weakly correlated
36 L1ME1 3 n.s 99.0 Weakly correlated
37 L1P1 3 n.s 19.6 Weakly correlated
38 L2c 3 n.s 99.0 Weakly correlated
39 LTR10E 3 **** 28.9 Weakly correlated
40 LTR2C 3 **** 19.6 Weakly correlated
41 THE1B-int 3 n.s 43.0 Highly correlated
42 THE1D-int 3 * 28.9 Weakly correlated
43 AluSc8 2 n.s 74.0 Weakly correlated
44 AluSg7 2 n.s 74.0 Weakly correlated
45 AluSx3 2 n.s 74.0 Weakly correlated
46 AluSx4 2 n.s 74.0 Weakly correlated
47 AluYm1 2 * 19.6 Weakly correlated
48 FRAM 2 * 74.0 Weakly correlated
49 L1M2 2 n.s 99.0 Weakly correlated
50 L1M4 2 n.s 99.0 Weakly correlated
51 L1M4b 2 n.s 99.0 Weakly correlated
52 L1M5 2 n.s 99.0 Weakly correlated
53 L1MA4A 2 n.s 87.0 Weakly correlated
54 L1MA5A 2 n.s 87.0 Weakly correlated
55 L1MB2 2 n.s 99.0 Weakly correlated
56 L1MB8 2 n.s 99.0 Weakly correlated
57 L1MC5 2 n.s 99.0 Weakly correlated
58 L1MD1 2 n.s 99.0 Weakly correlated
59 L1ME3 2 n.s 99.0 Weakly correlated
60 L1ME3B 2 n.s 99.0 Weakly correlated
61 L1ME4b 2 n.s 99.0 Weakly correlated
62 LTR41 2 *** 99.0 Weakly correlated
63 LTR41B 2 *** 99.0 Weakly correlated
64 LTR50 2 ** 99.0 Weakly correlated
65 LTR67B 2 ** 99.0 Weakly correlated
66 MER4D1 2 ** 74.0 Weakly correlated
67 MER50-int 2 ** 43.0 Highly correlated
68 MER61-int 2 * 43.0 Highly correlated
69 MLT1A0 2 n.s 99.0 Weakly correlated
70 MLT1K 2 n.s 99.0 Weakly correlated
71 MSTA 2 n.s 43.0 Highly correlated
72 SVA_C 2 ** 15.2 Weakly correlated
73 SVA_D 2 n.s 15.2 Weakly correlated
74 THE1D 2 n.s 43.0 Highly correlated
75 AluJr4 1 n.s 74.0 Weakly correlated
76 AluSq 1 n.s 74.0 Weakly correlated
77 AluSq10 1 * 74.0 Weakly correlated
78 AluYa5 1 n.s 15.2 Weakly correlated
79 AluYc3 1 ** 74.0 Weakly correlated
80 AluYd8 1 *** 15.2 Weakly correlated
81 AluYh3 1 * 15.2 Weakly correlated
82 AluYk4 1 * 15.2 Weakly correlated
83 ERV24_Prim-int 1 ** 74.0 Weakly correlated
84 HAL1ME 1 n.s 99.0 Weakly correlated
85 HERV17-int 1 n.s 28.9 Weakly correlated
86 HERVE_a-int 1 * 28.9 Weakly correlated
87 HERVIP10F-int 1 * 28.9 Weakly correlated
88 HERVL-int 1 n.s 74.0 Weakly correlated
89 Harlequin-int 1 n.s 74.0 Weakly correlated
90 L1HS 1 n.s 8.6 Weakly correlated
91 L1M1 1 n.s 74.0 Weakly correlated
92 L1M2b 1 ** 87.0 Weakly correlated
93 L1M4c 1 n.s 99.0 Weakly correlated
94 L1MA3 1 n.s 74.0 Weakly correlated
95 L1MA8 1 n.s 87.0 Weakly correlated
96 L1MA9 1 n.s 99.0 Weakly correlated
97 L1MB3 1 n.s 99.0 Weakly correlated
98 L1MB7 1 n.s 99.0 Weakly correlated
99 L1MC 1 n.s 99.0 Weakly correlated
100 L1MC4 1 n.s 99.0 Weakly correlated
101 L1MC5a 1 n.s 99.0 Weakly correlated
102 L1MCa 1 n.s 99.0 Weakly correlated
103 L1MDa 1 n.s 99.0 Weakly correlated
104 L1ME2z 1 n.s 99.0 Weakly correlated
105 L1ME3A 1 n.s 99.0 Weakly correlated
106 L1ME3F 1 n.s 99.0 Weakly correlated
107 L1ME3G 1 n.s 99.0 Weakly correlated
108 L1MEc 1 n.s 99.0 Weakly correlated
109 L1MEd 1 n.s 99.0 Weakly correlated
110 L1MEf 1 n.s 99.0 Weakly correlated
111 L1P4 1 n.s 74.0 Weakly correlated
112 L1PA10 1 n.s 74.0 Weakly correlated
113 L1PA13 1 n.s 74.0 Weakly correlated
114 L1PA17 1 n.s 74.0 Weakly correlated
115 L1PA8A 1 n.s 74.0 Weakly correlated
116 L1PB3 1 n.s 74.0 Weakly correlated
117 L2 1 n.s 99.0 Weakly correlated
118 L3 1 n.s 99.0 Weakly correlated
119 LTR1 1 ** 43.0 Highly correlated
120 LTR12C 1 n.s 19.6 Weakly correlated
121 LTR12E 1 ** 19.6 Weakly correlated
122 LTR16A1 1 n.s 99.0 Weakly correlated
123 LTR17 1 * 28.9 Weakly correlated
124 LTR28 1 ** 43.0 Highly correlated
125 LTR29 1 ** 43.0 Highly correlated
126 LTR33 1 n.s 99.0 Weakly correlated
127 LTR42 1 ** 74.0 Weakly correlated
128 LTR54 1 ** 74.0 Weakly correlated
129 LTR61 1 *** 43.0 Highly correlated
130 LTR72 1 *** 74.0 Weakly correlated
131 MER21C 1 n.s 99.0 Weakly correlated
132 MER39B 1 * 74.0 Weakly correlated
133 MER41-int 1 n.s 74.0 Weakly correlated
134 MER4B 1 n.s 74.0 Weakly correlated
135 MER4D 1 * 74.0 Weakly correlated
136 MER57-int 1 n.s 87.0 Weakly correlated
137 MER57A-int 1 n.s 43.0 Highly correlated
138 MER57C2 1 ** 87.0 Weakly correlated
139 MER57D 1 ** 87.0 Weakly correlated
140 MER61A 1 ** 43.0 Highly correlated
141 MER61B 1 ** 43.0 Highly correlated
142 MER66-int 1 * 43.0 Highly correlated
143 MER72 1 * 43.0 Highly correlated
144 MER89 1 * 99.0 Weakly correlated
145 MER92B 1 ** 99.0 Weakly correlated
146 MIR3 1 n.s 99.0 Weakly correlated
147 MIRc 1 n.s 99.0 Weakly correlated
148 MLT1A 1 n.s 99.0 Weakly correlated
149 MLT1B 1 n.s 99.0 Weakly correlated
150 MLT1D 1 n.s 99.0 Weakly correlated
151 MLT1F1 1 n.s 99.0 Weakly correlated
152 MLT1G 1 n.s 99.0 Weakly correlated
153 MLT1I 1 n.s 99.0 Weakly correlated
154 MLT1J 1 n.s 99.0 Weakly correlated
155 MLT1J-int 1 * 99.0 Weakly correlated
156 MLT1J2 1 n.s 99.0 Weakly correlated
157 MLT1N2 1 n.s 99.0 Weakly correlated
158 MamGypLTR3a 1 ** 99.0 Weakly correlated
159 MamRTE1 1 n.s 99.0 Weakly correlated
160 PRIMA41-int 1 * 74.0 Weakly correlated
161 SVA_A 1 * 19.6 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 LOR1b 217 **** 74.0 Weakly correlated
2 LOR1a 127 **** 74.0 Weakly correlated
3 LTR2 5 **** 28.9 Weakly correlated
4 LTR2C 2 **** 19.6 Weakly correlated
5 THE1B-int 2 n.s 43.0 Highly correlated
6 L1PA4 1 n.s 19.6 Weakly correlated
7 AluSx 1 n.s 74.0 Weakly correlated
8 MamGypLTR3a 1 ** 99.0 Weakly correlated
9 MSTA 1 n.s 43.0 Highly correlated
10 AluY 1 n.s 74.0 Weakly correlated
11 L1ME4b 1 n.s 99.0 Weakly correlated
12 LTR67B 1 n.s 99.0 Weakly correlated
13 L1M4b 1 n.s 99.0 Weakly correlated
14 MER92B 1 ** 99.0 Weakly correlated
15 MER61B 1 ** 43.0 Highly correlated
16 LTR13 1 * 19.6 Weakly correlated
17 LTR10E 1 ** 28.9 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP
1 LOR1A 74.0 Weakly correlated
2 LOR1B 74.0 Weakly correlated