ZRdb KZFP & Repeats
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Human_ZNF12

  • Protein
    Zinc finger protein 12
  • Length
    697
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    99.0 Mya
  • Uniprot_ID
    P17014
  • NCBI_ID
    7559
Sequence:
MNKSLGPVSFKDVAVDFTQEEWQQLDPEQKITYRDVMLENYSNLVSVGYHIIKPDVISKLEQGEEPWIVEGEFLLQSYPDEVWQTDDLIERIQEEENKPSRQTVFIETLIEERGNVPGKTFDVETNPVPSRKIAYKNSLCDSCEKCLTSVSEYISSDGSYARMKADECSGCGKSLLHIKLEKTHPGDQAYEFNQNGEPYTLNEESLYQKIRILEKPFEYIECQKAFQKDTVFVNHMEEKPYKWNGSEIAFLQMSDLTVHQTSHMEMKPYECSECGKSFCKKSKFIIHQRTHTGEKPYECNQCGKSFCQKGTLTVHQRTHTGEKPYECNECGKNFYQKLHLIQHQRTHSGEKPYECSYCGKSFCQKTHLTQHQRTHSGERPYVCHDCGKTFSQKSALNDHQKIHTGVKLYKCSECGKCFCRKSTLTTHLRTHTGEKPYECNECGKFFSRLSYLTVHYRTHSGEKPYECNECGKTFYLNSALMRHQRVHTGEKPYECNECGKLFSQLSYLTIHHRTHSGVKPYECSECGKTFYQNSALCRHRRIHKGEKPYECYICGKFFSQMSYLTIHHRIHSGEKPYECSECGKTFCQNSALNRHQRTHTGEKAYECYECGKCFSQMSYLTIHHRIHSGEKPFECNECGKAFSRMSYLTVHYRTHSGEKPYECTECGKKFYHKSAFNSHQRIHRRGNMNVIDVGRLL
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 8..79
2 C2h2 269..291
3 C2h2 297..319
4 C2h2 325..347
5 C2h2 353..375
6 C2h2 381..403
7 C2h2 409..431
8 C2h2 437..459
9 C2h2 465..487
10 C2h2 493..515
11 C2h2 521..543
12 C2h2 549..571
13 C2h2 577..599
14 C2h2 605..627
15 C2h2 633..655
16 C2h2 661..683
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component centrosome
2 Cellular Component nucleoplasm
3 Cellular Component nucleus
4 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
5 Molecular Function metal ion binding
6 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
7 Molecular Function sequence-specific double-stranded DNA binding
8 Biological Process negative regulation of DNA-templated transcription
9 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 MLT1I 185 **** 99.0 Highly correlated
2 MIRb 41 ** 99.0 Highly correlated
3 MLT1J2 35 **** 99.0 Highly correlated
4 L2c 34 * 99.0 Highly correlated
5 L2a 31 n.s 99.0 Highly correlated
6 MLT1D 28 **** 99.0 Highly correlated
7 MIR 27 n.s 99.0 Highly correlated
8 L2b 22 * 99.0 Highly correlated
9 MIRc 22 *** 99.0 Highly correlated
10 MLT1B 19 **** 99.0 Highly correlated
11 L2 14 n.s 99.0 Highly correlated
12 AluJb 13 n.s 74.0 Weakly correlated
13 MIR3 13 * 99.0 Highly correlated
14 AluJr 10 n.s 74.0 Weakly correlated
15 AluSx 10 n.s 74.0 Weakly correlated
16 AluSz 10 n.s 74.0 Weakly correlated
17 MLT1A0 10 * 99.0 Highly correlated
18 MLT1C 9 * 94.0 Weakly correlated
19 AluY 8 n.s 74.0 Weakly correlated
20 MLT1A 8 *** 99.0 Highly correlated
21 AluJo 7 n.s 74.0 Weakly correlated
22 AluSc8 7 n.s 74.0 Weakly correlated
23 L3 7 n.s 99.0 Highly correlated
24 MLT1K 7 * 99.0 Highly correlated
25 AluSc 6 n.s 74.0 Weakly correlated
26 LTR10A 6 **** 28.9 Weakly correlated
27 AluSx1 5 n.s 74.0 Weakly correlated
28 MLT1J 5 n.s 99.0 Highly correlated
29 AluJr4 4 n.s 74.0 Weakly correlated
30 AluSg 4 n.s 74.0 Weakly correlated
31 FRAM 4 ** 74.0 Weakly correlated
32 L1MEd 4 n.s 99.0 Highly correlated
33 MLT1A1 4 * 87.0 Weakly correlated
34 MLT1I-int 4 **** 99.0 Highly correlated
35 MLT1J1 4 ** 99.0 Highly correlated
36 L1P3 3 n.s 74.0 Weakly correlated
37 L1PBa 3 n.s 74.0 Weakly correlated
38 MER50 3 * 43.0 Weakly correlated
39 AluSq 2 n.s 74.0 Weakly correlated
40 AluSq2 2 n.s 74.0 Weakly correlated
41 AluSx3 2 n.s 74.0 Weakly correlated
42 AluSx4 2 n.s 74.0 Weakly correlated
43 ERVL-B4-int 2 n.s 99.0 Highly correlated
44 FLAM_C 2 n.s 74.0 Weakly correlated
45 HAL1ME 2 n.s 99.0 Highly correlated
46 L1MB8 2 n.s 99.0 Highly correlated
47 L1MC4a 2 n.s 99.0 Highly correlated
48 L1MC5 2 n.s 99.0 Highly correlated
49 L1PA2 2 n.s 15.2 Weakly correlated
50 L1PA5 2 n.s 19.6 Weakly correlated
51 L1PB1 2 n.s 74.0 Weakly correlated
52 LTR10F 2 *** 28.9 Weakly correlated
53 LTR12C 2 n.s 19.6 Weakly correlated
54 LTR78B 2 * 99.0 Highly correlated
55 MER51A 2 ** 43.0 Weakly correlated
56 MSTB 2 n.s 43.0 Weakly correlated
57 MSTD-int 2 * 74.0 Weakly correlated
58 MamRTE1 2 n.s 99.0 Highly correlated
59 AluSg4 1 n.s 74.0 Weakly correlated
60 AluSp 1 n.s 74.0 Weakly correlated
61 AluSz6 1 n.s 74.0 Weakly correlated
62 AluYa5 1 n.s 15.2 Weakly correlated
63 AluYh9 1 **** 15.2 Weakly correlated
64 AluYj4 1 n.s 0.0 Weakly correlated
65 AmnSINE1 1 * 319.0 Weakly correlated
66 CR1-16_AMi 1 ** 319.0 Weakly correlated
67 CR1-3_Croc 1 * 319.0 Weakly correlated
68 CR1-L3A_Croc 1 *** 319.0 Weakly correlated
69 ERVL-E-int 1 n.s 99.0 Highly correlated
70 FLAM_A 1 n.s 74.0 Weakly correlated
71 HERVK13-int 1 ** 19.6 Weakly correlated
72 L1M3 1 n.s 99.0 Highly correlated
73 L1M5 1 n.s 99.0 Highly correlated
74 L1M6B 1 ** 99.0 Highly correlated
75 L1MA4 1 n.s 87.0 Weakly correlated
76 L1MA4A 1 n.s 87.0 Weakly correlated
77 L1MA5 1 n.s 87.0 Weakly correlated
78 L1MB7 1 n.s 99.0 Highly correlated
79 L1MC 1 n.s 99.0 Highly correlated
80 L1MC1 1 n.s 99.0 Highly correlated
81 L1MC4 1 n.s 99.0 Highly correlated
82 L1MDa 1 n.s 99.0 Highly correlated
83 L1ME3A 1 n.s 99.0 Highly correlated
84 L1ME3C 1 n.s 99.0 Highly correlated
85 L1ME3E 1 n.s 99.0 Highly correlated
86 L1ME4a 1 n.s 99.0 Highly correlated
87 L1ME4b 1 n.s 99.0 Highly correlated
88 L1MEc 1 n.s 99.0 Highly correlated
89 L1MEi 1 n.s 99.0 Highly correlated
90 L1P1 1 n.s 19.6 Weakly correlated
91 L1P4 1 n.s 74.0 Weakly correlated
92 L1P4a 1 n.s 74.0 Weakly correlated
93 L1PA3 1 n.s 19.6 Weakly correlated
94 L1PA4 1 n.s 19.6 Weakly correlated
95 L1PBa1 1 n.s 74.0 Weakly correlated
96 LOR1-int 1 n.s 74.0 Weakly correlated
97 LTR101_Mam 1 * 99.0 Highly correlated
98 LTR10B1 1 ** 28.9 Weakly correlated
99 LTR13 1 n.s 19.6 Weakly correlated
100 LTR14C 1 ** 28.9 Weakly correlated
101 LTR16A 1 n.s 99.0 Highly correlated
102 LTR16A2 1 n.s 99.0 Highly correlated
103 LTR16C 1 n.s 99.0 Highly correlated
104 LTR1A2 1 n.s 43.0 Weakly correlated
105 LTR22B 1 ** 28.9 Weakly correlated
106 LTR33B 1 * 99.0 Highly correlated
107 LTR38-int 1 *** 74.0 Weakly correlated
108 LTR50 1 n.s 99.0 Highly correlated
109 LTR54 1 * 74.0 Weakly correlated
110 LTR55 1 ** 99.0 Highly correlated
111 LTR72B 1 *** 74.0 Weakly correlated
112 LTR79 1 n.s 99.0 Highly correlated
113 LTR8B 1 n.s 43.0 Weakly correlated
114 LTR9D 1 * 43.0 Weakly correlated
115 MER110 1 * 99.0 Highly correlated
116 MER21A 1 n.s 74.0 Weakly correlated
117 MER39B 1 n.s 74.0 Weakly correlated
118 MER41E 1 ** 74.0 Weakly correlated
119 MER4CL34 1 * 43.0 Weakly correlated
120 MER67A 1 ** 99.0 Highly correlated
121 MER76 1 * 99.0 Highly correlated
122 MER77 1 n.s 99.0 Highly correlated
123 MIR1_Amn 1 n.s 319.0 Weakly correlated
124 MLT1A1-int 1 * 87.0 Weakly correlated
125 MLT1D-int 1 * 99.0 Highly correlated
126 MLT1E1A 1 n.s 99.0 Highly correlated
127 MLT1E3 1 n.s 99.0 Highly correlated
128 MLT1F1 1 n.s 99.0 Highly correlated
129 MLT1G 1 n.s 99.0 Highly correlated
130 MLT1G3 1 n.s 99.0 Highly correlated
131 MLT1H 1 n.s 99.0 Highly correlated
132 MLT1J2-int 1 * 99.0 Highly correlated
133 MLT1L 1 n.s 99.0 Highly correlated
134 MLT1M 1 * 99.0 Highly correlated
135 MLT2C2 1 * 99.0 Highly correlated
136 MLT2E 1 ** 99.0 Highly correlated
137 MLT2F 1 n.s 99.0 Highly correlated
138 MamSINE1 1 n.s 99.0 Highly correlated
139 SVA_A 1 * 19.6 Weakly correlated
140 THE1B-int 1 n.s 43.0 Weakly correlated
141 THE1D 1 n.s 43.0 Weakly correlated
142 X9_LINE 1 ** 319.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 MLT1I 161 **** 99.0 Highly correlated
2 MLT1J2 31 **** 99.0 Highly correlated
3 MLT1D 27 **** 99.0 Highly correlated
4 MLT1B 17 **** 99.0 Highly correlated
5 MLT1A0 8 n.s 99.0 Highly correlated
6 MLT1A 7 ** 99.0 Highly correlated
7 MLT1C 7 n.s 94.0 Weakly correlated
8 MLT1J 5 n.s 99.0 Highly correlated
9 MLT1A1 4 * 87.0 Weakly correlated
10 MLT1J1 4 ** 99.0 Highly correlated
11 ERVL-B4-int 2 n.s 99.0 Highly correlated
12 L2 2 n.s 99.0 Highly correlated
13 L2a 2 n.s 99.0 Highly correlated
14 MLT1I-int 1 * 99.0 Highly correlated
15 MLT1D-int 1 * 99.0 Highly correlated
16 MSTD-int 1 n.s 74.0 Weakly correlated
17 MLT1L 1 n.s 99.0 Highly correlated
18 AluJr 1 n.s 74.0 Weakly correlated
19 MLT1A1-int 1 * 87.0 Weakly correlated
20 MIRc 1 n.s 99.0 Highly correlated
21 MIRb 1 n.s 99.0 Highly correlated
22 MIR 1 n.s 99.0 Highly correlated
23 LTR22B 1 ** 28.9 Weakly correlated
24 LOR1-int 1 n.s 74.0 Weakly correlated
25 L3 1 n.s 99.0 Highly correlated
26 HERVK13-int 1 ** 19.6 Weakly correlated
27 AmnSINE1 1 * 319.0 Weakly correlated
28 AluSc 1 n.s 74.0 Weakly correlated
29 AluJr4 1 n.s 74.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP