ZRdb KZFP & Repeats
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Human_ZNF100

  • Protein
    Zinc finger protein 100
  • Length
    542
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    28.9 Mya
  • Time of Changing in binding specificity
    28.9 Mya
  • Uniprot_ID
    Q8IYN0
  • NCBI_ID
    163227
Sequence:
MDDPRYGMCPLKGASGCPGAERSLLVQSYFEKGPLTFRDVAIEFSLEEWQCLDSAQQGLYRKVMLENYRNLVFLAGIALTKPDLITCLEQGKEPWNIKRHEMVAKPPVICSHFPQDLWAEQDIKDSFQEAILKKYGKYGHDNLQLQKGCKSVDECKVHKEHDNKLNQCLITTQSNIFQCDPSAKVFHTFSNSNRHKIRHTRKKPFKCKKCEKSFCMLLHLTQHKRFHITENSYQCKDCGKAFNWFSTLTTHRRIHTGEKPYKCEECGKAFNRSSHLTTHKIIHTGEKPYRCEECGKAFNRSSHLTTHKRIHTGVKPYKCTECGKAFNRSSHLTTHRIIHTGEKPYKCEECGKAFNQSSTLTTHKITHAGEKPYKCEECGKAFYRFSYLTKHKTSHTGEKFYKCEECGKGFNWSSALTKHKRIHTGEKPYKCEECGKAFNESSNLTTHKMIHTGEKPYKCDECGKAFNRSSQLTAHKMIHTGEKPYKCEECGKAFNRSSTLTKHKITHTGEKSYKWEECGKDFNQSLSLIKQNNSYWRETLQM
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 35..107
2 dec2h2 177..199
3 C2h2 205..227
4 C2h2 233..255
5 C2h2 261..283
6 C2h2 289..311
7 C2h2 317..339
8 C2h2 345..367
9 C2h2 373..395
10 C2h2 401..423
11 C2h2 429..451
12 C2h2 457..479
13 C2h2 485..507
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of DNA-templated transcription
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 THE1A 2263 **** 43.0 Moderately correlated
2 THE1B 549 **** 43.0 Moderately correlated
3 THE1D 232 **** 43.0 Moderately correlated
4 THE1C 103 **** 43.0 Moderately correlated
5 L2a 40 n.s 99.0 Weakly correlated
6 AluSx1 37 n.s 74.0 Weakly correlated
7 AluY 32 n.s 74.0 Weakly correlated
8 AluSx 29 n.s 74.0 Weakly correlated
9 HERVE-int 28 **** 19.6 Weakly correlated
10 L2c 24 n.s 99.0 Weakly correlated
11 MIRb 24 n.s 99.0 Weakly correlated
12 THE1A-int 21 **** 43.0 Moderately correlated
13 AluSx3 20 n.s 74.0 Weakly correlated
14 THE1C-int 19 **** 43.0 Moderately correlated
15 AluJb 18 n.s 74.0 Weakly correlated
16 AluSz 16 n.s 74.0 Weakly correlated
17 MER74B 14 **** 99.0 Weakly correlated
18 AluSc 13 n.s 74.0 Weakly correlated
19 AluSc8 13 n.s 74.0 Weakly correlated
20 AluSg 13 n.s 74.0 Weakly correlated
21 MIR 13 n.s 99.0 Weakly correlated
22 MIR3 12 n.s 99.0 Weakly correlated
23 AluJr 11 n.s 74.0 Weakly correlated
24 L1PA5 11 n.s 19.6 Weakly correlated
25 L2b 11 n.s 99.0 Weakly correlated
26 AluSq2 10 n.s 74.0 Weakly correlated
27 LTR10A 10 **** 28.9 Highly correlated
28 MIRc 10 n.s 99.0 Weakly correlated
29 AluSp 9 n.s 74.0 Weakly correlated
30 AluSq 9 n.s 74.0 Weakly correlated
31 THE1D-int 9 n.s 28.9 Highly correlated
32 AluSz6 8 n.s 74.0 Weakly correlated
33 MSTA 8 n.s 43.0 Moderately correlated
34 L1P3 7 n.s 74.0 Weakly correlated
35 L1PA2 7 n.s 15.2 Weakly correlated
36 AluJo 6 n.s 74.0 Weakly correlated
37 L1M4 6 n.s 99.0 Weakly correlated
38 L1PA4 6 n.s 19.6 Weakly correlated
39 LTR8 6 n.s 43.0 Moderately correlated
40 ERV3-16A3_I-int 5 n.s 99.0 Weakly correlated
41 HAL1 5 n.s 99.0 Weakly correlated
42 L1M5 5 n.s 99.0 Weakly correlated
43 L1MEc 5 n.s 99.0 Weakly correlated
44 LTR33 5 n.s 99.0 Weakly correlated
45 MLT1H 5 n.s 99.0 Weakly correlated
46 MSTB1 5 n.s 74.0 Weakly correlated
47 THE1B-int 5 n.s 43.0 Moderately correlated
48 AluYc 4 n.s 74.0 Weakly correlated
49 L1M4b 4 n.s 99.0 Weakly correlated
50 L1MCb 4 n.s 99.0 Weakly correlated
51 L1P1 4 n.s 19.6 Weakly correlated
52 L1PA7 4 n.s 74.0 Weakly correlated
53 LTR86B1 4 **** 99.0 Weakly correlated
54 MER50-int 4 ** 43.0 Moderately correlated
55 MLT1B 4 n.s 99.0 Weakly correlated
56 AluSc5 3 n.s 74.0 Weakly correlated
57 AluYh9 3 **** 15.2 Weakly correlated
58 FRAM 3 n.s 74.0 Weakly correlated
59 HERVK-int 3 n.s 28.9 Highly correlated
60 L1MEd 3 n.s 99.0 Weakly correlated
61 L1MEf 3 n.s 99.0 Weakly correlated
62 L1MEh 3 n.s 99.0 Weakly correlated
63 L1P4 3 n.s 74.0 Weakly correlated
64 L1PA8 3 n.s 74.0 Weakly correlated
65 L1PB4 3 n.s 99.0 Weakly correlated
66 L2 3 n.s 99.0 Weakly correlated
67 L3 3 n.s 99.0 Weakly correlated
68 LTR13 3 * 19.6 Weakly correlated
69 MER50 3 n.s 43.0 Moderately correlated
70 MIR1_Amn 3 n.s 319.0 Weakly correlated
71 MLT1C 3 n.s 94.0 Weakly correlated
72 MLT1J 3 n.s 99.0 Weakly correlated
73 AluYa5 2 n.s 15.2 Weakly correlated
74 AluYj4 2 n.s 0.0 Weakly correlated
75 AluYm1 2 n.s 19.6 Weakly correlated
76 ERVL-B4-int 2 n.s 99.0 Weakly correlated
77 HERVL-int 2 n.s 74.0 Weakly correlated
78 L1MA3 2 n.s 74.0 Weakly correlated
79 L1MC4 2 n.s 99.0 Weakly correlated
80 L1MC5 2 n.s 99.0 Weakly correlated
81 L1MD2 2 n.s 99.0 Weakly correlated
82 L1ME3A 2 n.s 99.0 Weakly correlated
83 LTR10F 2 * 28.9 Highly correlated
84 LTR12C 2 n.s 19.6 Weakly correlated
85 LTR18A 2 *** 43.0 Moderately correlated
86 LTR41 2 n.s 99.0 Weakly correlated
87 LTR86A1 2 ** 99.0 Weakly correlated
88 MER39B 2 n.s 74.0 Weakly correlated
89 MER52D 2 n.s 74.0 Weakly correlated
90 MER57F 2 ** 74.0 Weakly correlated
91 MER66A 2 ** 43.0 Moderately correlated
92 MER66B 2 n.s 43.0 Moderately correlated
93 MLT1D 2 n.s 99.0 Weakly correlated
94 MLT1F-int 2 * 99.0 Weakly correlated
95 MLT1J1 2 n.s 99.0 Weakly correlated
96 MLT1L 2 n.s 99.0 Weakly correlated
97 MLT2F 2 n.s 99.0 Weakly correlated
98 MSTD 2 n.s 74.0 Weakly correlated
99 MamGypLTR1c 2 * 99.0 Weakly correlated
100 SVA_D 2 n.s 15.2 Weakly correlated
101 AluSg4 1 n.s 74.0 Weakly correlated
102 AluSg7 1 n.s 74.0 Weakly correlated
103 AluSq10 1 n.s 74.0 Weakly correlated
104 AluYh3 1 n.s 15.2 Weakly correlated
105 HERV9N-int 1 n.s 19.6 Weakly correlated
106 HERVL18-int 1 n.s 43.0 Moderately correlated
107 L1M1 1 n.s 74.0 Weakly correlated
108 L1M2 1 n.s 99.0 Weakly correlated
109 L1M4a1 1 n.s 99.0 Weakly correlated
110 L1MA5A 1 n.s 87.0 Weakly correlated
111 L1MA7 1 n.s 87.0 Weakly correlated
112 L1MA8 1 n.s 87.0 Weakly correlated
113 L1MA9 1 n.s 99.0 Weakly correlated
114 L1MB7 1 n.s 99.0 Weakly correlated
115 L1MC1 1 n.s 99.0 Weakly correlated
116 L1MC4a 1 n.s 99.0 Weakly correlated
117 L1MCa 1 n.s 99.0 Weakly correlated
118 L1MDa 1 n.s 99.0 Weakly correlated
119 L1MDb 1 n.s 99.0 Weakly correlated
120 L1ME4b 1 n.s 99.0 Weakly correlated
121 L1MEi 1 n.s 99.0 Weakly correlated
122 L1PA10 1 n.s 74.0 Weakly correlated
123 L1PA12 1 n.s 74.0 Weakly correlated
124 L1PA16 1 n.s 74.0 Weakly correlated
125 L1PB1 1 n.s 74.0 Weakly correlated
126 L2-1_AMi 1 n.s 319.0 Weakly correlated
127 L2-3_Crp 1 n.s 431.0 Weakly correlated
128 LOR1b 1 n.s 74.0 Weakly correlated
129 LTR12E 1 * 19.6 Weakly correlated
130 LTR16B2 1 n.s 99.0 Weakly correlated
131 LTR16C 1 n.s 99.0 Weakly correlated
132 LTR2752 1 n.s 43.0 Moderately correlated
133 LTR42 1 * 74.0 Weakly correlated
134 LTR52 1 n.s 99.0 Weakly correlated
135 LTR7B 1 n.s 28.9 Highly correlated
136 LTR88b 1 n.s 99.0 Weakly correlated
137 MER11A 1 n.s 28.9 Highly correlated
138 MER11C 1 n.s 19.6 Weakly correlated
139 MER34A 1 n.s 99.0 Weakly correlated
140 MER4-int 1 n.s 74.0 Weakly correlated
141 MER4D1 1 n.s 74.0 Weakly correlated
142 MER68-int 1 n.s 99.0 Weakly correlated
143 MLT1E3 1 n.s 99.0 Weakly correlated
144 MLT1F 1 n.s 99.0 Weakly correlated
145 MLT1F1 1 n.s 99.0 Weakly correlated
146 MLT1F1-int 1 * 99.0 Weakly correlated
147 MLT1G 1 n.s 99.0 Weakly correlated
148 MLT1I 1 n.s 99.0 Weakly correlated
149 MSTA-int 1 n.s 43.0 Moderately correlated
150 MSTC 1 n.s 74.0 Weakly correlated
151 MamRTE1 1 n.s 99.0 Weakly correlated
152 MamSINE1 1 n.s 99.0 Weakly correlated
153 SVA_A 1 n.s 19.6 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 THE1A 1001 **** 43.0 Moderately correlated
2 THE1B 316 **** 43.0 Moderately correlated
3 THE1D 125 **** 43.0 Moderately correlated
4 THE1C 55 **** 43.0 Moderately correlated
5 L2a 10 n.s 99.0 Weakly correlated
6 HERVE-int 9 **** 19.6 Weakly correlated
7 L2c 5 n.s 99.0 Weakly correlated
8 MSTA 5 n.s 43.0 Moderately correlated
9 AluSz 3 n.s 74.0 Weakly correlated
10 MLT1H 3 n.s 99.0 Weakly correlated
11 MIR3 2 n.s 99.0 Weakly correlated
12 MIR 2 n.s 99.0 Weakly correlated
13 MLT1C 2 n.s 94.0 Weakly correlated
14 L3 2 n.s 99.0 Weakly correlated
15 L2b 2 n.s 99.0 Weakly correlated
16 MSTB1 2 n.s 74.0 Weakly correlated
17 L1MCb 2 n.s 99.0 Weakly correlated
18 ERV3-16A3_I-int 2 n.s 99.0 Weakly correlated
19 AluSz6 2 n.s 74.0 Weakly correlated
20 AluSx 2 n.s 74.0 Weakly correlated
21 MSTC 1 n.s 74.0 Weakly correlated
22 MLT2F 1 n.s 99.0 Weakly correlated
23 MLT1L 1 n.s 99.0 Weakly correlated
24 MSTD 1 n.s 74.0 Weakly correlated
25 MamGypLTR1c 1 n.s 99.0 Weakly correlated
26 THE1B-int 1 n.s 43.0 Moderately correlated
27 MLT1F-int 1 n.s 99.0 Weakly correlated
28 MLT1D 1 n.s 99.0 Weakly correlated
29 THE1C-int 1 n.s 43.0 Moderately correlated
30 MLT1B 1 n.s 99.0 Weakly correlated
31 MIRb 1 n.s 99.0 Weakly correlated
32 LTR12C 1 n.s 19.6 Weakly correlated
33 L1MEh 1 n.s 99.0 Weakly correlated
34 AluSc8 1 n.s 74.0 Weakly correlated
35 AluSx1 1 n.s 74.0 Weakly correlated
36 AluY 1 n.s 74.0 Weakly correlated
37 AluYh3 1 n.s 15.2 Weakly correlated
38 ERVL-B4-int 1 n.s 99.0 Weakly correlated
39 HERV9N-int 1 n.s 19.6 Weakly correlated
40 L1M4 1 n.s 99.0 Weakly correlated
41 L1M4b 1 n.s 99.0 Weakly correlated
42 L1MC5 1 n.s 99.0 Weakly correlated
43 MER66A 1 * 43.0 Moderately correlated
44 L1PA4 1 n.s 19.6 Weakly correlated
45 L1PB4 1 n.s 99.0 Weakly correlated
46 L2 1 n.s 99.0 Weakly correlated
47 L2-3_Crp 1 n.s 431.0 Weakly correlated
48 AluSc5 1 n.s 74.0 Weakly correlated
49 LTR41 1 n.s 99.0 Weakly correlated
50 LTR86B1 1 * 99.0 Weakly correlated
51 MER50-int 1 n.s 43.0 Moderately correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP
1 HERVE-INT 19.6 Weakly correlated
2 THE1A 43.0 Moderately correlated
3 THE1B 43.0 Moderately correlated
4 THE1C 43.0 Moderately correlated