ZRdb KZFP & Repeats
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Human_ZNF10

  • Protein
    Zinc finger protein 10
  • Length
    573
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    99.0 Mya
  • Uniprot_ID
    P21506
  • NCBI_ID
    7556
Sequence:
MDAKSLTAWSRTLVTFKDVFVDFTREEWKLLDTAQQIVYRNVMLENYKNLVSLGYQLTKPDVILRLEKGEEPWLVEREIHQETHPDSETAFEIKSSVSSRSIFKDKQSCDIKMEGMARNDLWYLSLEEVWKCRDQLDKYQENPERHLRQVAFTQKKVLTQERVSESGKYGGNCLLPAQLVLREYFHKRDSHTKSLKHDLVLNGHQDSCASNSNECGQTFCQNIHLIQFARTHTGDKSYKCPDNDNSLTHGSSLGISKGIHREKPYECKECGKFFSWRSNLTRHQLIHTGEKPYECKECGKSFSRSSHLIGHQKTHTGEEPYECKECGKSFSWFSHLVTHQRTHTGDKLYTCNQCGKSFVHSSRLIRHQRTHTGEKPYECPECGKSFRQSTHLILHQRTHVRVRPYECNECGKSYSQRSHLVVHHRIHTGLKPFECKDCGKCFSRSSHLYSHQRTHTGEKPYECHDCGKSFSQSSALIVHQRIHTGEKPYECCQCGKAFIRKNDLIKHQRIHVGEETYKCNQCGIIFSQNSPFIVHQIAHTGEQFLTCNQCGTALVNTSNLIGYQTNHIRENAY
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 14..85
2 C2h2 206..232
3 C2h2 265..287
4 C2h2 293..315
5 C2h2 321..343
6 C2h2 349..371
7 C2h2 377..399
8 C2h2 405..427
9 C2h2 433..455
10 C2h2 461..483
11 C2h2 489..511
12 C2h2 517..539
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Cellular Component protein-containing complex
3 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
4 Molecular Function DNA-binding transcription repressor activity, RNA polymerase II-specific
5 Molecular Function metal ion binding
6 Molecular Function RNA polymerase II transcription regulatory region sequence-specific DNA binding
7 Biological Process negative regulation of transcription by RNA polymerase II
8 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1MB7 156 **** 99.0 Highly correlated
2 L1M4 108 **** 99.0 Highly correlated
3 L1M5 92 **** 99.0 Highly correlated
4 L1MB8 72 **** 99.0 Highly correlated
5 L1MB5 34 **** 99.0 Highly correlated
6 L1ME3A 34 **** 99.0 Highly correlated
7 L1ME1 33 **** 99.0 Highly correlated
8 L1PA7 24 **** 74.0 Weakly correlated
9 L1PA5 22 **** 19.6 Weakly correlated
10 L1PA10 19 **** 74.0 Weakly correlated
11 L1MB4 16 **** 99.0 Highly correlated
12 L1ME3 16 **** 99.0 Highly correlated
13 L1PA4 16 ** 19.6 Weakly correlated
14 L1ME2 15 **** 99.0 Highly correlated
15 L1PA13 15 **** 74.0 Weakly correlated
16 AluSx1 14 n.s 74.0 Weakly correlated
17 L1PREC2 14 **** 43.0 Weakly correlated
18 AluJb 13 n.s 74.0 Weakly correlated
19 AluY 13 n.s 74.0 Weakly correlated
20 L1PA14 13 **** 74.0 Weakly correlated
21 L1PA6 13 *** 28.9 Weakly correlated
22 L1ME2z 12 **** 99.0 Highly correlated
23 L1PA3 12 n.s 19.6 Weakly correlated
24 AluJo 11 n.s 74.0 Weakly correlated
25 AluJr 11 n.s 74.0 Weakly correlated
26 L1MEd 11 *** 99.0 Highly correlated
27 L1PA15 11 *** 74.0 Weakly correlated
28 AluSx 10 n.s 74.0 Weakly correlated
29 AluSz 10 n.s 74.0 Weakly correlated
30 L1PA8 10 *** 74.0 Weakly correlated
31 L2c 10 n.s 99.0 Highly correlated
32 L1ME3Cz 9 **** 99.0 Highly correlated
33 L1MEc 9 ** 99.0 Highly correlated
34 AluSq2 8 n.s 74.0 Weakly correlated
35 L1ME3B 8 **** 99.0 Highly correlated
36 L1ME3F 8 **** 99.0 Highly correlated
37 AluSg 7 n.s 74.0 Weakly correlated
38 L1MA8 7 ** 87.0 Weakly correlated
39 L1P3 7 **** 74.0 Weakly correlated
40 L2a 7 n.s 99.0 Highly correlated
41 MLT1B 7 ** 99.0 Highly correlated
42 AluSz6 6 n.s 74.0 Weakly correlated
43 L1ME3D 6 **** 99.0 Highly correlated
44 L1P1 6 *** 19.6 Weakly correlated
45 L1PA11 6 ** 74.0 Weakly correlated
46 MIRb 6 n.s 99.0 Highly correlated
47 AluSq 5 * 74.0 Weakly correlated
48 FLAM_C 5 ** 74.0 Weakly correlated
49 L1M3 5 *** 99.0 Highly correlated
50 L1MA7 5 * 87.0 Weakly correlated
51 L1MB3 5 n.s 99.0 Highly correlated
52 L1ME3G 5 * 99.0 Highly correlated
53 L1ME4a 5 n.s 99.0 Highly correlated
54 L1MEf 5 n.s 99.0 Highly correlated
55 AluSc 4 n.s 74.0 Weakly correlated
56 AluSc8 4 n.s 74.0 Weakly correlated
57 FLAM_A 4 ** 74.0 Weakly correlated
58 L1MC5 4 n.s 99.0 Highly correlated
59 L1ME3C 4 *** 99.0 Highly correlated
60 L1PA8A 4 * 74.0 Weakly correlated
61 MLT1C 4 n.s 94.0 Weakly correlated
62 AluJr4 3 n.s 74.0 Weakly correlated
63 L1M2 3 n.s 99.0 Highly correlated
64 L1M4b 3 * 99.0 Highly correlated
65 L1MA9 3 n.s 99.0 Highly correlated
66 L1MC3 3 n.s 99.0 Highly correlated
67 L1ME3E 3 ** 99.0 Highly correlated
68 L1MEg 3 n.s 99.0 Highly correlated
69 L1PA16 3 n.s 74.0 Weakly correlated
70 L1PA17 3 n.s 74.0 Weakly correlated
71 L1PA2 3 n.s 15.2 Weakly correlated
72 LTR10A 3 **** 28.9 Weakly correlated
73 MIR 3 n.s 99.0 Highly correlated
74 AluSg4 2 n.s 74.0 Weakly correlated
75 AluSp 2 n.s 74.0 Weakly correlated
76 AluSx3 2 n.s 74.0 Weakly correlated
77 L1M1 2 n.s 74.0 Weakly correlated
78 L1M4a2 2 ** 99.0 Highly correlated
79 L1MB2 2 n.s 99.0 Highly correlated
80 L1MC 2 n.s 99.0 Highly correlated
81 L1MC4a 2 n.s 99.0 Highly correlated
82 L1MD 2 n.s 99.0 Highly correlated
83 L1MDa 2 n.s 99.0 Highly correlated
84 L1ME4b 2 n.s 99.0 Highly correlated
85 L1MEi 2 * 99.0 Highly correlated
86 L1P4 2 * 74.0 Weakly correlated
87 L2 2 n.s 99.0 Highly correlated
88 L2b 2 n.s 99.0 Highly correlated
89 L3 2 n.s 99.0 Highly correlated
90 L4_A_Mam 2 * 99.0 Highly correlated
91 MIR3 2 n.s 99.0 Highly correlated
92 MLT1D 2 n.s 99.0 Highly correlated
93 THE1B 2 n.s 43.0 Weakly correlated
94 THE1D 2 n.s 43.0 Weakly correlated
95 AluSc5 1 n.s 74.0 Weakly correlated
96 AluSg7 1 n.s 74.0 Weakly correlated
97 AluSx4 1 n.s 74.0 Weakly correlated
98 AluYb8 1 n.s 15.2 Weakly correlated
99 AluYj4 1 * 0.0 Weakly correlated
100 AluYm1 1 n.s 19.6 Weakly correlated
101 FAM 1 * 87.0 Weakly correlated
102 HAL1 1 n.s 99.0 Highly correlated
103 HAL1M8 1 n.s 99.0 Highly correlated
104 HAL1b 1 n.s 99.0 Highly correlated
105 HERV16-int 1 * 99.0 Highly correlated
106 L1M3c 1 * 99.0 Highly correlated
107 L1MA1 1 n.s 74.0 Weakly correlated
108 L1MA10 1 n.s 99.0 Highly correlated
109 L1MA6 1 n.s 87.0 Weakly correlated
110 L1MC1 1 n.s 99.0 Highly correlated
111 L1MC5a 1 n.s 99.0 Highly correlated
112 L1MCa 1 n.s 99.0 Highly correlated
113 L1MD1 1 n.s 99.0 Highly correlated
114 L1MD2 1 n.s 99.0 Highly correlated
115 L1ME4c 1 n.s 99.0 Highly correlated
116 L1ME5 1 n.s 99.0 Highly correlated
117 L1PA12 1 n.s 74.0 Weakly correlated
118 L1PB 1 n.s 74.0 Weakly correlated
119 L1PB4 1 n.s 99.0 Highly correlated
120 LTR12D 1 * 19.6 Weakly correlated
121 LTR13 1 * 19.6 Weakly correlated
122 LTR33 1 n.s 99.0 Highly correlated
123 LTR90B 1 *** 99.0 Highly correlated
124 MER21C 1 n.s 99.0 Highly correlated
125 MER41C 1 ** 74.0 Weakly correlated
126 MER49 1 * 43.0 Weakly correlated
127 MER57C2 1 ** 87.0 Weakly correlated
128 MER61E 1 ** 43.0 Weakly correlated
129 MER66C 1 ** 43.0 Weakly correlated
130 MIRc 1 n.s 99.0 Highly correlated
131 MLT1A 1 n.s 99.0 Highly correlated
132 MLT1A0 1 n.s 99.0 Highly correlated
133 MLT1A0-int 1 * 99.0 Highly correlated
134 MLT1D-int 1 ** 99.0 Highly correlated
135 MLT1E1A 1 n.s 99.0 Highly correlated
136 MLT1F2 1 n.s 99.0 Highly correlated
137 MLT1G 1 n.s 99.0 Highly correlated
138 MLT1H1 1 n.s 99.0 Highly correlated
139 MLT1J 1 n.s 99.0 Highly correlated
140 MLT1N2 1 n.s 99.0 Highly correlated
141 MLT2F 1 * 99.0 Highly correlated
142 MSTA 1 n.s 43.0 Weakly correlated
143 MSTA-int 1 n.s 43.0 Weakly correlated
144 MSTB2 1 * 74.0 Weakly correlated
145 MSTC 1 n.s 74.0 Weakly correlated
146 THE1B-int 1 n.s 43.0 Weakly correlated
147 THE1C 1 n.s 43.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1MB7 149 **** 99.0 Highly correlated
2 L1M4 99 **** 99.0 Highly correlated
3 L1M5 84 **** 99.0 Highly correlated
4 L1MB8 71 **** 99.0 Highly correlated
5 L1MB5 33 **** 99.0 Highly correlated
6 L1ME1 31 **** 99.0 Highly correlated
7 L1ME3A 31 **** 99.0 Highly correlated
8 L1PA7 22 **** 74.0 Weakly correlated
9 L1PA5 20 **** 19.6 Weakly correlated
10 L1PA10 17 **** 74.0 Weakly correlated
11 L1ME3 15 **** 99.0 Highly correlated
12 L1PREC2 14 **** 43.0 Weakly correlated
13 L1PA13 14 **** 74.0 Weakly correlated
14 L1ME2 13 **** 99.0 Highly correlated
15 L1PA4 13 n.s 19.6 Weakly correlated
16 L1MB4 13 **** 99.0 Highly correlated
17 L1PA6 12 ** 28.9 Weakly correlated
18 L1ME2z 12 **** 99.0 Highly correlated
19 L1PA14 11 **** 74.0 Weakly correlated
20 L1PA8 10 *** 74.0 Weakly correlated
21 L1PA15 9 ** 74.0 Weakly correlated
22 L1ME3Cz 9 **** 99.0 Highly correlated
23 L1ME3F 8 **** 99.0 Highly correlated
24 L1MEc 8 * 99.0 Highly correlated
25 L1PA3 8 n.s 19.6 Weakly correlated
26 L1MEd 7 * 99.0 Highly correlated
27 L1ME3B 7 **** 99.0 Highly correlated
28 L2c 7 n.s 99.0 Highly correlated
29 MLT1B 7 ** 99.0 Highly correlated
30 L1ME3D 6 **** 99.0 Highly correlated
31 L1ME3G 5 * 99.0 Highly correlated
32 L1PA11 5 * 74.0 Weakly correlated
33 MIRb 5 n.s 99.0 Highly correlated
34 L1P1 5 ** 19.6 Weakly correlated
35 L1P3 5 ** 74.0 Weakly correlated
36 L1ME3C 4 *** 99.0 Highly correlated
37 L1PA8A 4 * 74.0 Weakly correlated
38 L1ME4a 4 n.s 99.0 Highly correlated
39 L2a 4 n.s 99.0 Highly correlated
40 L1MEf 4 n.s 99.0 Highly correlated
41 L1MA7 4 * 87.0 Weakly correlated
42 L1MA8 4 n.s 87.0 Weakly correlated
43 L1MB3 3 n.s 99.0 Highly correlated
44 L1MEg 3 n.s 99.0 Highly correlated
45 MLT1C 3 n.s 94.0 Weakly correlated
46 L1ME3E 3 ** 99.0 Highly correlated
47 L1M4b 3 * 99.0 Highly correlated
48 L1M3 3 * 99.0 Highly correlated
49 L1MC5 3 n.s 99.0 Highly correlated
50 L1PA17 3 n.s 74.0 Weakly correlated
51 L1MA9 3 n.s 99.0 Highly correlated
52 L1P4 2 * 74.0 Weakly correlated
53 MLT1D 2 n.s 99.0 Highly correlated
54 L1PA16 2 n.s 74.0 Weakly correlated
55 L1MB2 2 n.s 99.0 Highly correlated
56 L1ME4b 2 n.s 99.0 Highly correlated
57 L1MDa 2 n.s 99.0 Highly correlated
58 L1MC 2 n.s 99.0 Highly correlated
59 L2b 2 n.s 99.0 Highly correlated
60 L1MC4a 2 n.s 99.0 Highly correlated
61 L1MC3 2 n.s 99.0 Highly correlated
62 MER66C 1 ** 43.0 Weakly correlated
63 AluJb 1 n.s 74.0 Weakly correlated
64 THE1B-int 1 n.s 43.0 Weakly correlated
65 MSTA-int 1 n.s 43.0 Weakly correlated
66 MLT1J 1 n.s 99.0 Highly correlated
67 MIR 1 n.s 99.0 Highly correlated
68 MER21C 1 n.s 99.0 Highly correlated
69 LTR90B 1 *** 99.0 Highly correlated
70 L3 1 n.s 99.0 Highly correlated
71 MIRc 1 n.s 99.0 Highly correlated
72 L4_A_Mam 1 n.s 99.0 Highly correlated
73 L1PB4 1 n.s 99.0 Highly correlated
74 L1MC5a 1 n.s 99.0 Highly correlated
75 AluSc8 1 n.s 74.0 Weakly correlated
76 AluSz 1 n.s 74.0 Weakly correlated
77 HERV16-int 1 * 99.0 Highly correlated
78 L1M1 1 n.s 74.0 Weakly correlated
79 L1M2 1 n.s 99.0 Highly correlated
80 L1M4a2 1 n.s 99.0 Highly correlated
81 L1MA1 1 n.s 74.0 Weakly correlated
82 L1MA10 1 n.s 99.0 Highly correlated
83 L1MA6 1 n.s 87.0 Weakly correlated
84 L1MC1 1 n.s 99.0 Highly correlated
85 L1PA2 1 n.s 15.2 Weakly correlated
86 L1MCa 1 n.s 99.0 Highly correlated
87 L1MD 1 n.s 99.0 Highly correlated
88 L1MD1 1 n.s 99.0 Highly correlated
89 L1MD2 1 n.s 99.0 Highly correlated
90 L1ME4c 1 n.s 99.0 Highly correlated
91 L1ME5 1 n.s 99.0 Highly correlated
92 L1MEi 1 n.s 99.0 Highly correlated
93 L1P2 1 n.s 28.9 Weakly correlated
94 L1PA12 1 n.s 74.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP
1 L1M5 99.0 Highly correlated