ZRdb KZFP & Repeats
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Human_ZKSCAN4

  • Protein
    Zinc finger protein with KRAB and SCAN domains 4
  • Length
    545
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    99.0 Mya
  • Uniprot_ID
    Q969J2
  • NCBI_ID
    387032
Sequence:
MAREPRKNAALDAQSAEDQTGLLTVKVEKEEASALTAEVRAPCSPARGPERSRQRFRGFRYPEAAGPREALSRLRELCGQWLQPEMHSKEQILELLVLEQFLTILPGNLQSWVREQHPESGEEVVVLLEYLERQLDEPAPQVPVGDQGQELLCCKMALLTQTQGSQSSQCQPMKALFKHESLGSQPLHDRVLQVPGLAQGGCCREDAMVASRLTPGSQGLLKMEDVALTLTPGWTQLDSSQVNLYRDEKQENHSSLVSLGGEIQTKSRDLPPVKKLPEKEHGKICHLREDIAQIPTHAEAGEQEGRLQRKQKNAIGSRRHYCHECGKSFAQSSGLTKHRRIHTGEKPYECEDCGKTFIGSSALVIHQRVHTGEKPYECEECGKVFSHSSNLIKHQRTHTGEKPYECDDCGKTFSQSCSLLEHHKIHTGEKPYQCNMCGKAFRRNSHLLRHQRIHGDKNVQNPEHGESWESQGRTESQWENTEAPVSYKCNECERSFTRNRSLIEHQKIHTGEKPYQCDTCGKGFTRTSYLVQHQRSHVGKKTLSQ
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 scan 53..135
2 KRAB 221..317
3 C2h2 320..342
4 C2h2 348..370
5 C2h2 376..398
6 C2h2 404..426
7 C2h2 432..454
8 C2h2 487..509
9 C2h2 515..537
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleoplasm
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function identical protein binding
4 Molecular Function metal ion binding
5 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
6 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 AluYj4 13 **** 0.0 Weakly correlated
2 L1P3 10 **** 74.0 Weakly correlated
3 AluSp 9 n.s 74.0 Weakly correlated
4 AluSc8 8 ** 74.0 Weakly correlated
5 LTR8 7 **** 43.0 Weakly correlated
6 L1PA5 6 n.s 19.6 Weakly correlated
7 AluYa8 5 **** 15.2 Weakly correlated
8 L1MB7 4 n.s 99.0 Highly correlated
9 FRAM 4 *** 74.0 Weakly correlated
10 MER21B 4 *** 99.0 Highly correlated
11 LTR10A 4 **** 28.9 Weakly correlated
12 L2a 4 n.s 99.0 Highly correlated
13 AluJb 3 n.s 74.0 Weakly correlated
14 AluYm1 3 ** 19.6 Weakly correlated
15 LTR10F 3 **** 28.9 Weakly correlated
16 L1P1 2 n.s 19.6 Weakly correlated
17 MIRb 2 n.s 99.0 Highly correlated
18 L1MEg 2 n.s 99.0 Highly correlated
19 L1MC4 2 n.s 99.0 Highly correlated
20 L1MB8 2 n.s 99.0 Highly correlated
21 AluJo 2 n.s 74.0 Weakly correlated
22 L1M4 2 n.s 99.0 Highly correlated
23 HUERS-P3b-int 2 *** 43.0 Weakly correlated
24 AluY 2 n.s 74.0 Weakly correlated
25 AluSz 1 n.s 74.0 Weakly correlated
26 SVA_C 1 * 15.2 Weakly correlated
27 SVA_A 1 * 19.6 Weakly correlated
28 MLT1L 1 n.s 99.0 Highly correlated
29 MIRc 1 n.s 99.0 Highly correlated
30 AluSg4 1 n.s 74.0 Weakly correlated
31 AluSq 1 n.s 74.0 Weakly correlated
32 AluSq2 1 n.s 74.0 Weakly correlated
33 LTR13 1 * 19.6 Weakly correlated
34 AluSx 1 n.s 74.0 Weakly correlated
35 LTR10B1 1 *** 28.9 Weakly correlated
36 AluSx3 1 n.s 74.0 Weakly correlated
37 L2c 1 n.s 99.0 Highly correlated
38 L2b 1 n.s 99.0 Highly correlated
39 L1M3 1 n.s 99.0 Highly correlated
40 L1PB 1 n.s 74.0 Weakly correlated
41 L1PA10 1 n.s 74.0 Weakly correlated
42 L1P4 1 n.s 74.0 Weakly correlated
43 AluYh9 1 **** 15.2 Weakly correlated
44 AluYi6 1 *** 15.2 Weakly correlated
45 HAL1 1 n.s 99.0 Highly correlated
46 L1MD 1 n.s 99.0 Highly correlated
47 HERV17-int 1 n.s 28.9 Weakly correlated
48 L1HS 1 n.s 8.6 Weakly correlated
49 L1MA9 1 n.s 99.0 Highly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 AluYj4 6 **** 0.0 Weakly correlated
2 AluYa8 3 **** 15.2 Weakly correlated
3 AluY 2 n.s 74.0 Weakly correlated
4 FRAM 2 * 74.0 Weakly correlated
5 L1PA5 2 n.s 19.6 Weakly correlated
6 AluJo 1 n.s 74.0 Weakly correlated
7 HUERS-P3b-int 1 * 43.0 Weakly correlated
8 AluJb 1 n.s 74.0 Weakly correlated
9 AluSq 1 n.s 74.0 Weakly correlated
10 SVA_A 1 * 19.6 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP