ZRdb KZFP & Repeats
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Human_ZKSCAN3

  • Protein
    Zinc finger protein with KRAB and SCAN domains 3
  • Length
    538
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    99.0 Mya
  • Uniprot_ID
    Q9BRR0
  • NCBI_ID
    80317
Sequence:
MARELSESTALDAQSTEDQMELLVIKVEEEEAGFPSSPDLGSEGSRERFRGFRYPEAAGPREALSRLRELCRQWLQPEMHSKEQILELLVLEQFLTILPGNLQSWVREQHPESGEEVVVLLEYLERQLDEPAPQVSGVDQGQELLCCKMALLTPAPGSQSSQFQLMKALLKHESVGSQPLQDRVLQVPVLAHGGCCREDKVVASRLTPESQGLLKVEDVALTLTPEWTQQDSSQGNLCRDEKQENHGSLVSLGDEKQTKSRDLPPAEELPEKEHGKISCHLREDIAQIPTCAEAGEQEGRLQRKQKNATGGRRHICHECGKSFAQSSGLSKHRRIHTGEKPYECEECGKAFIGSSALVIHQRVHTGEKPYECEECGKAFSHSSDLIKHQRTHTGEKPYECDDCGKTFSQSCSLLEHHRIHTGEKPYQCSMCGKAFRRSSHLLRHQRIHTGDKNVQEPEQGEAWKSRMESQLENVETPMSYKCNECERSFTQNTGLIEHQKIHTGEKPYQCNACGKGFTRISYLVQHQRSHVGKNILSQ
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 scan 46..128
2 KRAB 214..274
3 C2h2 314..336
4 C2h2 342..364
5 C2h2 370..392
6 C2h2 398..420
7 C2h2 426..448
8 C2h2 480..502
9 C2h2 508..530
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component cytoplasm
2 Cellular Component nucleoplasm
3 Cellular Component nucleus
4 Molecular Function chromatin binding
5 Molecular Function DNA binding
6 Molecular Function DNA-binding transcription factor activity
7 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
8 Molecular Function DNA-binding transcription repressor activity, RNA polymerase II-specific
9 Molecular Function metal ion binding
10 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
11 Molecular Function sequence-specific DNA binding
12 Biological Process autophagy
13 Biological Process lysosome organization
14 Biological Process negative regulation of autophagy
15 Biological Process negative regulation of cellular senescence
16 Biological Process negative regulation of DNA-templated transcription
17 Biological Process negative regulation of transcription by RNA polymerase II
18 Biological Process positive regulation of DNA-templated transcription
19 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 AluJb 6 n.s 74.0 Weakly correlated
2 LTR10A 3 **** 28.9 Weakly correlated
3 LTR10F 3 **** 28.9 Weakly correlated
4 L1PA5 3 n.s 19.6 Weakly correlated
5 L1P3 3 ** 74.0 Weakly correlated
6 AluJo 2 n.s 74.0 Weakly correlated
7 L1P1 2 * 19.6 Weakly correlated
8 MER50 2 *** 43.0 Weakly correlated
9 MIRb 2 n.s 99.0 Highly correlated
10 AluY 2 n.s 74.0 Weakly correlated
11 AluSz 2 n.s 74.0 Weakly correlated
12 AluJr 2 n.s 74.0 Weakly correlated
13 MLT1F1 1 * 99.0 Highly correlated
14 MLT1F 1 * 99.0 Highly correlated
15 MLT1D 1 n.s 99.0 Highly correlated
16 MIRc 1 n.s 99.0 Highly correlated
17 MLT1G3 1 ** 99.0 Highly correlated
18 MER39B 1 ** 74.0 Weakly correlated
19 MLT1H2 1 * 99.0 Highly correlated
20 LTR33 1 n.s 99.0 Highly correlated
21 LTR13 1 ** 19.6 Weakly correlated
22 MLT1I 1 n.s 99.0 Highly correlated
23 MamRTE1 1 * 99.0 Highly correlated
24 L2b 1 n.s 99.0 Highly correlated
25 L2a 1 n.s 99.0 Highly correlated
26 L1PA2 1 n.s 15.2 Weakly correlated
27 L1P4 1 * 74.0 Weakly correlated
28 L1MEc 1 n.s 99.0 Highly correlated
29 L1ME4b 1 n.s 99.0 Highly correlated
30 L1M4 1 n.s 99.0 Highly correlated
31 HAL1 1 n.s 99.0 Highly correlated
32 AmnSINE2 1 **** 319.0 Weakly correlated
33 AluYm1 1 * 19.6 Weakly correlated
34 AluYh9 1 **** 15.2 Weakly correlated
35 AluSz6 1 n.s 74.0 Weakly correlated
36 AluSx1 1 n.s 74.0 Weakly correlated
37 AluSx 1 n.s 74.0 Weakly correlated
38 AluSc8 1 n.s 74.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 AluYh9 1 **** 15.2 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP