ZRdb KZFP & Repeats
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Human_ZKSCAN2

  • Protein
    Zinc finger protein with KRAB and SCAN domains 2
  • Length
    967
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    180.0 Mya
  • Time of Changing in binding specificity
    180.0 Mya
  • Uniprot_ID
    Q63HK3
  • NCBI_ID
    342357
Sequence:
MAVALDSQIDAPLEVEGCLIMKVEKDPEWASEPILEGSDSSETFRKCFRQFCYEDVTGPHEAFSKLWELCCRWLKPEMRSKEQILELLVIEQFLTILPEKIQAWAQKQCPQSGEEAVALVVHLEKETGRLRQQVSSPVHREKHSPLGAAWEVADFQPEQVETQPRAVSREEPGSLHSGHQEQLNRKRERRPLPKNARPSPWVPALADEWNTLDQEVTTTRLPAGSQEPVKDVHVARGFSYRKSVHQIPAQRDLYRDFRKENVGNVVSLGSAVSTSNKITRLEQRKEPWTLGLHSSNKRSILRSNYVKEKSVHAIQVPARSAGKTWREQQQWGLEDEKIAGVHWSYEETKTFLAILKESRFYETLQACPRNSQVYGAVAEWLRECGFLRTPEQCRTKFKSLQKSYRKVRNGHMLEPCAFFEDMDALLNPAARAPSTDKPKEMIPVPRLKRIAISAKEHISLVEEEEAAEDSDDDEIGIEFIRKSEIHGAPVLFQNLSGVHWGYEETKTFLDILRETRFYEALQACHRKSKLYGAVAEQLRECGFLRTPEQCRTKFKSLQKSYRKVKNGHVLESCAFYKEMDALINSRASAPSPSTPEEVPSPSRQERGGIEVEPQEPTGWEPEETSQEAVIEDSCSERMSEEEIVQEPEFQGPPGLLQSPNDFEIGSSIKEDPTQIVYKDMEQHRALIEKSKRVVSQSTDPSKYRKRECISGRQWENLQGIRQGKPMSQPRDLGKAVVHQRPFVGKRPYRLLKYGESFGRSTRLMCRMTHHKENPYKCGVCGKCFGRSRSLIRHQRIHTGEKPFKCLDCGKSFNDSSNFGAHQRIHTGEKPYRCGECGKCFSQSSSLIIHQRTHTGEKPYQCGECGKSFTNSSHFSAHRRVHTGENPYKCVDCEKSFNNCTRFREHRRIHTGEKPYGCAQCGKRFSKSSVLTKHREVHVREKPLPHPPSLYCPENPHKGKTDEFRKTF
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 scan 45..127
2 KRAB 229..300
3 C2h2 775..797
4 C2h2 803..825
5 C2h2 831..853
6 C2h2 859..881
7 C2h2 887..909
8 C2h2 915..937
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 AluY 25 ** 74.0 Weakly correlated
2 AluSx 18 n.s 74.0 Weakly correlated
3 AluJb 16 n.s 74.0 Weakly correlated
4 AluSp 13 * 74.0 Weakly correlated
5 AluSx1 10 n.s 74.0 Weakly correlated
6 AluSc 10 ** 74.0 Weakly correlated
7 AluSz 9 n.s 74.0 Weakly correlated
8 AluSq2 9 n.s 74.0 Weakly correlated
9 AluSx3 8 * 74.0 Weakly correlated
10 AluSc8 8 ** 74.0 Weakly correlated
11 MIR 7 n.s 99.0 Weakly correlated
12 L2b 7 n.s 99.0 Weakly correlated
13 MIRb 6 n.s 99.0 Weakly correlated
14 AluSg 5 n.s 74.0 Weakly correlated
15 L1P3 5 ** 74.0 Weakly correlated
16 L2a 5 n.s 99.0 Weakly correlated
17 LTR8 5 **** 43.0 Weakly correlated
18 AluSz6 5 n.s 74.0 Weakly correlated
19 MIRc 4 n.s 99.0 Weakly correlated
20 LTR10A 4 **** 28.9 Weakly correlated
21 AluSg4 4 ** 74.0 Weakly correlated
22 AluJr 4 n.s 74.0 Weakly correlated
23 AluSq 4 n.s 74.0 Weakly correlated
24 AluYa5 3 ** 15.2 Weakly correlated
25 L2c 3 n.s 99.0 Weakly correlated
26 L1PA2 3 n.s 15.2 Weakly correlated
27 L1MC4 3 n.s 99.0 Weakly correlated
28 LTR75 2 **** 99.0 Weakly correlated
29 LTR12C 2 n.s 19.6 Weakly correlated
30 LTR10F 2 **** 28.9 Weakly correlated
31 L1ME4b 2 n.s 99.0 Weakly correlated
32 MIR3 2 n.s 99.0 Weakly correlated
33 MER50 2 * 43.0 Weakly correlated
34 L1PA5 2 n.s 19.6 Weakly correlated
35 L1P1 2 n.s 19.6 Weakly correlated
36 L1M5 2 n.s 99.0 Weakly correlated
37 AluYe5 2 *** 74.0 Weakly correlated
38 AluSc5 2 n.s 74.0 Weakly correlated
39 AluSg7 2 n.s 74.0 Weakly correlated
40 AluYm1 2 * 19.6 Weakly correlated
41 MER39B 1 * 74.0 Weakly correlated
42 AluYc 1 n.s 74.0 Weakly correlated
43 AluYb8 1 n.s 15.2 Weakly correlated
44 LTR13 1 * 19.6 Weakly correlated
45 LTR1A2 1 * 43.0 Weakly correlated
46 LTR37B 1 * 99.0 Weakly correlated
47 LTR41 1 * 99.0 Weakly correlated
48 AluSx4 1 n.s 74.0 Weakly correlated
49 LTR75B 1 *** 99.0 Weakly correlated
50 AluSq4 1 * 74.0 Weakly correlated
51 LTR82A 1 * 99.0 Weakly correlated
52 MER11C 1 n.s 19.6 Weakly correlated
53 MER34A1 1 ** 99.0 Weakly correlated
54 LTR1 1 ** 43.0 Weakly correlated
55 AluSq10 1 * 74.0 Weakly correlated
56 MER50-int 1 * 43.0 Weakly correlated
57 MER66B 1 * 43.0 Weakly correlated
58 AluJr4 1 n.s 74.0 Weakly correlated
59 AluJo 1 n.s 74.0 Weakly correlated
60 MLT1A0 1 n.s 99.0 Weakly correlated
61 MLT1D 1 n.s 99.0 Weakly correlated
62 MLT1F1 1 n.s 99.0 Weakly correlated
63 MLT1J 1 n.s 99.0 Weakly correlated
64 MSTD 1 n.s 74.0 Weakly correlated
65 MamRTE1 1 n.s 99.0 Weakly correlated
66 SVA_C 1 * 15.2 Weakly correlated
67 FLAM_C 1 n.s 74.0 Weakly correlated
68 L1M2 1 n.s 99.0 Weakly correlated
69 L1M4 1 n.s 99.0 Weakly correlated
70 HERVE_a-int 1 * 28.9 Weakly correlated
71 L1MA8 1 n.s 87.0 Weakly correlated
72 L1MC3 1 n.s 99.0 Weakly correlated
73 HAL1 1 n.s 99.0 Weakly correlated
74 L1MC5a 1 n.s 99.0 Weakly correlated
75 L1ME3G 1 n.s 99.0 Weakly correlated
76 L1ME4a 1 n.s 99.0 Weakly correlated
77 Alu 1 ** 74.0 Weakly correlated
78 L1MEf 1 n.s 99.0 Weakly correlated
79 L1MEg1 1 ** 99.0 Weakly correlated
80 FRAM 1 n.s 74.0 Weakly correlated
81 AluYc3 1 ** 74.0 Weakly correlated
82 L1P4 1 n.s 74.0 Weakly correlated
83 L1PA10 1 n.s 74.0 Weakly correlated
84 FLAM_A 1 n.s 74.0 Weakly correlated
85 L1PA3 1 n.s 19.6 Weakly correlated
86 L1PA4 1 n.s 19.6 Weakly correlated
87 L1PB1 1 n.s 74.0 Weakly correlated
88 L1PB2 1 n.s 74.0 Weakly correlated
89 L1PB4 1 n.s 99.0 Weakly correlated
90 AluYh9 1 **** 15.2 Weakly correlated
91 AluYf1 1 * 19.6 Weakly correlated
92 LFSINE_Vert 1 ** 319.0 Weakly correlated
93 L1HS 1 n.s 8.6 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 AluSx1 1 n.s 74.0 Weakly correlated
2 AluYh9 1 **** 15.2 Weakly correlated
3 L1PA10 1 n.s 74.0 Weakly correlated
4 AluSp 1 n.s 74.0 Weakly correlated
5 MIR 1 n.s 99.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP