ZRdb KZFP & Repeats
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Human_ZIM2

  • Protein
    Zinc finger imprinted 2
  • Length
    527
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    0.0 Mya
  • Time of Changing in binding specificity
    0.0 Mya
  • Uniprot_ID
    Q9NZV7
  • NCBI_ID
    23619
Sequence:
MYQPEDDNNSDVTSDDDMTRNRRESSPPHSVHSFSGDRDWDRRGRSRDMEPRDRWSHTRNPRSRMPPRDLSLPVVAKTSFEMDREDDRDSRAYESRSQDAESYQNVVDLAEDRKPHNTIQDNMENYRKLLSLGFLAQDSVPAEKRNTEMLDNLPSAGSQFPDFKHLGTFLVFEELVTFEDVLVDFSPEELSSLSAAQRNLYREVMLENYRNLVSLGHQFSKPDIISRLEEEESYAMETDSRHTVICQGESHDDPLEPHQGNQEKLLTPITMNDPKTLTPERSYGSDEFERSSNLSKQSKDPLGKDPQEGTAPGICTSPQSASQENKHNRCEFCKRTFSTQVALRRHERIHTGKKPYECKQCAEAFYLMPHLNRHQKTHSGRKTSGCNEGRKPSVQCANLCERVRIHSQEDYFECFQCGKAFLQNVHLLQHLKAHEAARVLPPGLSHSKTYLIRYQRKHDYVGERACQCCDCGRVFSRNSYLIQHYRTHTQERPYQCQLCGKCFGRPSYLTQHYQLHSQEKTVECDHC
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 176..246
2 C2h2 328..350
3 C2h2 356..378
4 C2h2 412..434
5 C2h2 466..488
6 C2h2 494..516
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function DNA-binding transcription repressor activity, RNA polymerase II-specific
4 Molecular Function RNA polymerase II transcription regulatory region sequence-specific DNA binding
5 Molecular Function zinc ion binding
6 Biological Process negative regulation of transcription by RNA polymerase II
7 Biological Process regulation of DNA-templated transcription
8 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 LTR10A 3 **** 28.9 Weakly correlated
2 L1PA2 3 * 15.2 Weakly correlated
3 AluJb 3 n.s 74.0 Weakly correlated
4 L1P1 1 * 19.6 Weakly correlated
5 MLT1L 1 * 99.0 Weakly correlated
6 MIRb 1 n.s 99.0 Weakly correlated
7 MER50-int 1 *** 43.0 Weakly correlated
8 MER50 1 ** 43.0 Weakly correlated
9 MER39B 1 *** 74.0 Weakly correlated
10 LTR13 1 *** 19.6 Weakly correlated
11 L2c 1 n.s 99.0 Weakly correlated
12 L2a 1 n.s 99.0 Weakly correlated
13 L1PA5 1 n.s 19.6 Weakly correlated
14 L1MC4 1 n.s 99.0 Weakly correlated
15 FRAM 1 ** 74.0 Weakly correlated
16 AluYm1 1 ** 19.6 Weakly correlated
17 AluYa5 1 ** 15.2 Weakly correlated
18 AluY 1 n.s 74.0 Weakly correlated
19 AluSz6 1 n.s 74.0 Weakly correlated
20 AluSx1 1 n.s 74.0 Weakly correlated
21 AluSx 1 n.s 74.0 Weakly correlated
22 AluSq2 1 n.s 74.0 Weakly correlated
23 AluSg 1 n.s 74.0 Weakly correlated
24 AluSc8 1 n.s 74.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L2c 1 n.s 99.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP