ZRdb KZFP & Repeats
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Human_ZIK1

  • Protein
    Zinc finger protein interacting with ribonucleoprotein K
  • Length
    487
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    94.0 Mya
  • Time of Changing in binding specificity
    87.0 Mya
  • Uniprot_ID
    Q3SY52
  • NCBI_ID
    284307
Sequence:
MAAAALRAPTQVTVSPETHMDLTKGCVTFEDIAIYFSQDEWGLLDEAQRLLYLEVMLENFALVASLGCGHGTEDEETPSDQNVSVGVSQSKAGSSTQKTQSCEMCVPVLKDILHLADLPGQKPYLVGECTNHHQHQKHHSAKKSLKRDMDRASYVKCCLFCMSLKPFRKWEVGKDLPAMLRLLRSLVFPGGKKPGTITECGEDIRSQKSHYKSGECGKASRHKHTPVYHPRVYTGKKLYECSKCGKAFRGKYSLVQHQRVHTGERPWECNECGKFFSQTSHLNDHRRIHTGERPYECSECGKLFRQNSSLVDHQKIHTGARPYECSQCGKSFSQKATLVKHQRVHTGERPYKCGECGNSFSQSAILNQHRRIHTGAKPYECGQCGKSFSQKATLIKHQRVHTGERPYKCGDCGKSFSQSSILIQHRRIHTGARPYECGQCGKSFSQKSGLIQHQVVHTGERPYECNKCGNSFSQCSSLIHHQKCHNT
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 27..136
2 C2h2 239..261
3 C2h2 267..289
4 C2h2 295..317
5 C2h2 323..345
6 C2h2 351..373
7 C2h2 379..401
8 C2h2 407..429
9 C2h2 435..457
10 C2h2 463..485
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 AluSx 14 ** 74.0 Weakly correlated
2 AluJb 10 n.s 74.0 Weakly correlated
3 AluJr 9 * 74.0 Weakly correlated
4 AluSq2 9 ** 74.0 Weakly correlated
5 L1MC1 9 **** 99.0 Moderately correlated
6 L2a 9 n.s 99.0 Moderately correlated
7 AluSx1 7 n.s 74.0 Weakly correlated
8 L2c 6 n.s 99.0 Moderately correlated
9 AluJo 5 n.s 74.0 Weakly correlated
10 MIR 5 n.s 99.0 Moderately correlated
11 MIRb 5 n.s 99.0 Moderately correlated
12 AluSg 4 n.s 74.0 Weakly correlated
13 AluSz6 4 n.s 74.0 Weakly correlated
14 AluY 4 n.s 74.0 Weakly correlated
15 L1MC3 4 * 99.0 Moderately correlated
16 AluSz 3 n.s 74.0 Weakly correlated
17 L1MC 3 ** 99.0 Moderately correlated
18 L1P3 3 ** 74.0 Weakly correlated
19 L1PA10 3 n.s 74.0 Weakly correlated
20 LTR10A 3 **** 28.9 Weakly correlated
21 MIRc 3 n.s 99.0 Moderately correlated
22 MLT1E1 3 **** 99.0 Moderately correlated
23 MSTA 3 * 43.0 Weakly correlated
24 AluJr4 2 n.s 74.0 Weakly correlated
25 AluSc 2 n.s 74.0 Weakly correlated
26 AluSp 2 n.s 74.0 Weakly correlated
27 HAL1 2 n.s 99.0 Moderately correlated
28 L1MA10 2 ** 99.0 Moderately correlated
29 L1MA2 2 n.s 74.0 Weakly correlated
30 L1MB3 2 n.s 99.0 Moderately correlated
31 L1MC4a 2 * 99.0 Moderately correlated
32 L1ME3B 2 * 99.0 Moderately correlated
33 L1MEc 2 n.s 99.0 Moderately correlated
34 L1P2 2 * 28.9 Weakly correlated
35 L1P4 2 ** 74.0 Weakly correlated
36 L1PA13 2 n.s 74.0 Weakly correlated
37 L1PA17 2 * 74.0 Weakly correlated
38 L1PA2 2 n.s 15.2 Weakly correlated
39 L1PA5 2 n.s 19.6 Weakly correlated
40 L2 2 n.s 99.0 Moderately correlated
41 L2b 2 n.s 99.0 Moderately correlated
42 L4_A_Mam 2 ** 99.0 Moderately correlated
43 LTR12F 2 **** 28.9 Weakly correlated
44 LTR54 2 **** 74.0 Weakly correlated
45 MER11A 2 *** 28.9 Weakly correlated
46 MIR3 2 n.s 99.0 Moderately correlated
47 MLT1F2 2 ** 99.0 Moderately correlated
48 MLT1H2 2 ** 99.0 Moderately correlated
49 MLT1L 2 * 99.0 Moderately correlated
50 MamGypLTR1b 2 **** 99.0 Moderately correlated
51 AluSg4 1 n.s 74.0 Weakly correlated
52 AluSg7 1 n.s 74.0 Weakly correlated
53 AluSq10 1 ** 74.0 Weakly correlated
54 AluSx3 1 n.s 74.0 Weakly correlated
55 AluYh9 1 **** 15.2 Weakly correlated
56 AluYi6 1 *** 15.2 Weakly correlated
57 HAL1ME 1 n.s 99.0 Moderately correlated
58 HERV16-int 1 * 99.0 Moderately correlated
59 HUERS-P1-int 1 ** 43.0 Weakly correlated
60 HUERS-P3b-int 1 ** 43.0 Weakly correlated
61 L1M4 1 n.s 99.0 Moderately correlated
62 L1M5 1 n.s 99.0 Moderately correlated
63 L1MA3 1 n.s 74.0 Weakly correlated
64 L1MA5 1 n.s 87.0 Highly correlated
65 L1MA7 1 n.s 87.0 Highly correlated
66 L1MA9 1 n.s 99.0 Moderately correlated
67 L1MB2 1 n.s 99.0 Moderately correlated
68 L1MB8 1 n.s 99.0 Moderately correlated
69 L1MC2 1 n.s 99.0 Moderately correlated
70 L1MC5a 1 n.s 99.0 Moderately correlated
71 L1MCc 1 * 99.0 Moderately correlated
72 L1MD 1 n.s 99.0 Moderately correlated
73 L1ME1 1 n.s 99.0 Moderately correlated
74 L1ME2 1 n.s 99.0 Moderately correlated
75 L1ME3 1 n.s 99.0 Moderately correlated
76 L1ME3Cz 1 n.s 99.0 Moderately correlated
77 L1ME3F 1 * 99.0 Moderately correlated
78 L1ME3G 1 n.s 99.0 Moderately correlated
79 L1ME4a 1 n.s 99.0 Moderately correlated
80 L1ME4b 1 n.s 99.0 Moderately correlated
81 L1ME4c 1 n.s 99.0 Moderately correlated
82 L1MEg 1 n.s 99.0 Moderately correlated
83 L1P1 1 n.s 19.6 Weakly correlated
84 L1PA15 1 n.s 74.0 Weakly correlated
85 L1PA16 1 n.s 74.0 Weakly correlated
86 L1PA4 1 n.s 19.6 Weakly correlated
87 L1PA7 1 n.s 74.0 Weakly correlated
88 L1PA8A 1 n.s 74.0 Weakly correlated
89 LTR103b_Mam 1 *** 99.0 Moderately correlated
90 LTR13 1 ** 19.6 Weakly correlated
91 LTR25-int 1 ** 43.0 Weakly correlated
92 LTR7B 1 ** 28.9 Weakly correlated
93 LTR80B 1 *** 99.0 Moderately correlated
94 MER11B 1 ** 19.6 Weakly correlated
95 MER39B 1 ** 74.0 Weakly correlated
96 MER4B-int 1 * 99.0 Moderately correlated
97 MER52C 1 ** 74.0 Weakly correlated
98 MER68 1 ** 99.0 Moderately correlated
99 MER76 1 ** 99.0 Moderately correlated
100 MLT1D 1 n.s 99.0 Moderately correlated
101 MLT1E1A 1 * 99.0 Moderately correlated
102 MLT1F1 1 * 99.0 Moderately correlated
103 MLT1H 1 n.s 99.0 Moderately correlated
104 MLT1O 1 * 99.0 Moderately correlated
105 MSTB1 1 * 74.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1MC1 9 **** 99.0 Moderately correlated
2 AluJr 6 n.s 74.0 Weakly correlated
3 AluSq2 6 n.s 74.0 Weakly correlated
4 AluSx 6 n.s 74.0 Weakly correlated
5 AluJb 5 n.s 74.0 Weakly correlated
6 L2a 5 n.s 99.0 Moderately correlated
7 AluJo 4 n.s 74.0 Weakly correlated
8 MLT1E1 3 **** 99.0 Moderately correlated
9 L2c 3 n.s 99.0 Moderately correlated
10 AluSz6 3 n.s 74.0 Weakly correlated
11 L1MC3 3 n.s 99.0 Moderately correlated
12 AluSx1 3 n.s 74.0 Weakly correlated
13 L1MC 2 * 99.0 Moderately correlated
14 MER11A 2 *** 28.9 Weakly correlated
15 MIR 2 n.s 99.0 Moderately correlated
16 L2b 2 n.s 99.0 Moderately correlated
17 LTR54 2 **** 74.0 Weakly correlated
18 L1ME3B 2 * 99.0 Moderately correlated
19 L1P2 2 * 28.9 Weakly correlated
20 MLT1F2 2 ** 99.0 Moderately correlated
21 L2 2 n.s 99.0 Moderately correlated
22 MLT1L 2 * 99.0 Moderately correlated
23 MSTA 2 n.s 43.0 Weakly correlated
24 AluSz 2 n.s 74.0 Weakly correlated
25 AluSp 2 n.s 74.0 Weakly correlated
26 L1PA8A 1 n.s 74.0 Weakly correlated
27 L4_A_Mam 1 * 99.0 Moderately correlated
28 LTR25-int 1 ** 43.0 Weakly correlated
29 L1PA7 1 n.s 74.0 Weakly correlated
30 L1PA16 1 n.s 74.0 Weakly correlated
31 MER11B 1 ** 19.6 Weakly correlated
32 MER4B-int 1 * 99.0 Moderately correlated
33 MER52C 1 ** 74.0 Weakly correlated
34 MIRc 1 n.s 99.0 Moderately correlated
35 MLT1D 1 n.s 99.0 Moderately correlated
36 MLT1E1A 1 * 99.0 Moderately correlated
37 MLT1H 1 n.s 99.0 Moderately correlated
38 MLT1F1 1 * 99.0 Moderately correlated
39 HAL1 1 n.s 99.0 Moderately correlated
40 L1MB8 1 n.s 99.0 Moderately correlated
41 AluJr4 1 n.s 74.0 Weakly correlated
42 AluSg4 1 n.s 74.0 Weakly correlated
43 AluSx3 1 n.s 74.0 Weakly correlated
44 HERV16-int 1 * 99.0 Moderately correlated
45 HUERS-P1-int 1 ** 43.0 Weakly correlated
46 L1M5 1 n.s 99.0 Moderately correlated
47 L1MA2 1 n.s 74.0 Weakly correlated
48 L1MA3 1 n.s 74.0 Weakly correlated
49 L1MA5 1 n.s 87.0 Highly correlated
50 L1MA7 1 n.s 87.0 Highly correlated
51 L1MA9 1 n.s 99.0 Moderately correlated
52 L1MB2 1 n.s 99.0 Moderately correlated
53 L1PA15 1 n.s 74.0 Weakly correlated
54 L1MC5a 1 n.s 99.0 Moderately correlated
55 L1MCc 1 * 99.0 Moderately correlated
56 L1ME2 1 n.s 99.0 Moderately correlated
57 L1ME3 1 n.s 99.0 Moderately correlated
58 L1ME3Cz 1 n.s 99.0 Moderately correlated
59 L1ME3F 1 * 99.0 Moderately correlated
60 L1ME3G 1 n.s 99.0 Moderately correlated
61 L1MEc 1 n.s 99.0 Moderately correlated
62 L1MEg 1 n.s 99.0 Moderately correlated
63 L1P4 1 n.s 74.0 Weakly correlated
64 L1PA10 1 n.s 74.0 Weakly correlated
65 L1PA13 1 n.s 74.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP