ZRdb KZFP & Repeats
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Human_ZFP92

  • Protein
    Zinc finger protein 92 homolog
  • Length
    416
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    99.0 Mya
  • Uniprot_ID
    A6NM28
  • NCBI_ID
    139735
Sequence:
MAAILLTTRPKVPVSFEDVSVYFTKTEWKLLDLRQKVLYKRVMLENYSHLVSLGFSFSKPHLISQLERGEGPWVADIPRTWATAGLHIGDRTQSKTSTSTQKHSGRQLPGADPQGGKEGQAARSSVLQRGAQGLGQSSAAGPQGPKGAEKRYLCQQCGKAFSRSSNLIKHRIIHSGEKPYACPECGKLFRRSFALLEHQRIHSGEKPYACPECSKTFTRSSNLIKHQVIHSGERPFACGDCGKLFRRSFALLEHARVHSGERPYACPECGKAFSRSSNLIEHQRTHRGEKPYACGQCAKAFKGVSQLIHHQRSHSGERPFACRECGKAFRGRSGLSQHRRVHSGEKPYECSDCGKAFGRRANLFKHQAVHGARRPAKAETARRLAGPGSTGPGSAVAATSPPRPSTAARPSRPSRR
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 14..85
2 C2h2 152..174
3 C2h2 180..202
4 C2h2 208..230
5 C2h2 236..258
6 C2h2 264..286
7 C2h2 292..314
8 C2h2 320..342
9 C2h2 348..370
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1P3 7 **** 74.0 Weakly correlated
2 AluSc8 5 * 74.0 Weakly correlated
3 AluJb 4 n.s 74.0 Weakly correlated
4 LTR10A 4 **** 28.9 Weakly correlated
5 MER21B 3 *** 99.0 Highly correlated
6 L1MB8 2 n.s 99.0 Highly correlated
7 L1P4 2 * 74.0 Weakly correlated
8 L1PA5 2 n.s 19.6 Weakly correlated
9 AluSx 1 n.s 74.0 Weakly correlated
10 AluSz 1 n.s 74.0 Weakly correlated
11 FRAM 1 n.s 74.0 Weakly correlated
12 L1HS 1 n.s 8.6 Weakly correlated
13 L1MA8 1 n.s 87.0 Weakly correlated
14 L1MEg 1 n.s 99.0 Highly correlated
15 L2c 1 n.s 99.0 Highly correlated
16 LTR10B1 1 *** 28.9 Weakly correlated
17 LTR13 1 ** 19.6 Weakly correlated
18 MLT1L 1 n.s 99.0 Highly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1P3 1 n.s 74.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP