ZRdb KZFP & Repeats
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Human_ZFP30

  • Protein
    Zinc finger protein 30 homolog
  • Length
    519
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    99.0 Mya
  • Uniprot_ID
    Q9Y2G7
  • NCBI_ID
    22835
Sequence:
MARDLVMFRDVAVDFSQEEWECLNSYQRNLYRDVILENYSNLVSLAGCSISKPDVITLLEQGKEPWMVVRDEKRRWTLDLESRYDTKKLFQGKDIYEMNLSQWKVMERIKSCGLEEQESPHEVCFRQVTKTTSEKMPTYRKLTSLPLYQKSHNREKPYECGECGKAFRVRQQLTFHQRIHTGEKPYECKECGKAFRQCAHLSRHQRIHTSDKLYECKKCGKIFTCGSDLRVHQRIHIGEKPYECKECGKAFRVRGQLNLHQRIHTGEKPYECKECGKAFRQYAHLTRHQRLNIAEKCYECKECGQAFLCSTGLRLHHKLHTGEKPYECKECGKAFRVRQQLTLHQRIHTGEKPYDCKECGKTFSRGYHLTLHQRIHTGEKPYECKECQKFFRRYSELISHQGIHIGEKPYECKECGKAFRLFSQLTQHQSIHFGEKPFKCKECEKTFRLLSQLTQHQSIHTGEKPYDCKECGKAFRLHSSLIQHQRIHSGEKPYKCKECKKAFRQHSHLTYHQRIHNVT
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 6..78
2 C2h2 158..180
3 C2h2 186..208
4 C2h2 214..236
5 C2h2 242..264
6 dec2h2 270..292
7 C2h2 298..320
8 C2h2 326..348
9 C2h2 354..376
10 C2h2 382..404
11 C2h2 410..432
12 C2h2 438..460
13 C2h2 466..488
14 C2h2 494..516
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1MEd 180 **** 99.0 Highly correlated
2 L1MEg 127 **** 99.0 Highly correlated
3 L1MEc 57 **** 99.0 Highly correlated
4 L2a 27 n.s 99.0 Highly correlated
5 AluJb 25 n.s 74.0 Weakly correlated
6 L1ME1 19 * 99.0 Highly correlated
7 L1ME3B 19 **** 99.0 Highly correlated
8 L2c 18 n.s 99.0 Highly correlated
9 HAL1 17 **** 99.0 Highly correlated
10 AluY 15 n.s 74.0 Weakly correlated
11 AluSz 14 n.s 74.0 Weakly correlated
12 L1MEi 13 **** 99.0 Highly correlated
13 AluSx1 12 n.s 74.0 Weakly correlated
14 AluJo 11 n.s 74.0 Weakly correlated
15 AluSx 11 n.s 74.0 Weakly correlated
16 L1MB8 11 * 99.0 Highly correlated
17 L2 11 n.s 99.0 Highly correlated
18 MIR 11 n.s 99.0 Highly correlated
19 AluSc8 10 * 74.0 Weakly correlated
20 AluJr 9 n.s 74.0 Weakly correlated
21 L1MC4 9 n.s 99.0 Highly correlated
22 L1ME4a 9 n.s 99.0 Highly correlated
23 L2b 9 n.s 99.0 Highly correlated
24 AluSp 8 n.s 74.0 Weakly correlated
25 AluYj4 8 **** 0.0 Weakly correlated
26 L1MB7 8 n.s 99.0 Highly correlated
27 L1ME3 8 ** 99.0 Highly correlated
28 L1ME3A 8 * 99.0 Highly correlated
29 L1P3 7 ** 74.0 Weakly correlated
30 L1PA16 7 n.s 74.0 Weakly correlated
31 MIRc 7 n.s 99.0 Highly correlated
32 L1MEf 6 n.s 99.0 Highly correlated
33 LTR8 6 *** 43.0 Weakly correlated
34 MIR3 6 n.s 99.0 Highly correlated
35 AluJr4 5 n.s 74.0 Weakly correlated
36 L1M5 5 n.s 99.0 Highly correlated
37 L1ME2z 5 * 99.0 Highly correlated
38 L1ME3C 5 *** 99.0 Highly correlated
39 MIRb 5 n.s 99.0 Highly correlated
40 MLT1A 5 * 99.0 Highly correlated
41 AluSg 4 n.s 74.0 Weakly correlated
42 AluSq2 4 n.s 74.0 Weakly correlated
43 L1M4 4 n.s 99.0 Highly correlated
44 L1MDa 4 n.s 99.0 Highly correlated
45 L1ME3F 4 ** 99.0 Highly correlated
46 L3b 4 ** 99.0 Highly correlated
47 LTR10A 4 **** 28.9 Weakly correlated
48 MLT1J 4 n.s 99.0 Highly correlated
49 MLT1K 4 n.s 99.0 Highly correlated
50 AluSc 3 n.s 74.0 Weakly correlated
51 AluSq 3 n.s 74.0 Weakly correlated
52 AluSz6 3 n.s 74.0 Weakly correlated
53 AluYm1 3 * 19.6 Weakly correlated
54 FLAM_C 3 n.s 74.0 Weakly correlated
55 FRAM 3 * 74.0 Weakly correlated
56 HUERS-P1-int 3 *** 43.0 Weakly correlated
57 L1M1 3 n.s 74.0 Weakly correlated
58 L1M4c 3 n.s 99.0 Highly correlated
59 L1MA6 3 n.s 87.0 Weakly correlated
60 L1MC5 3 n.s 99.0 Highly correlated
61 L1MCc 3 * 99.0 Highly correlated
62 L1MD1 3 n.s 99.0 Highly correlated
63 L1ME2 3 n.s 99.0 Highly correlated
64 L1ME3D 3 * 99.0 Highly correlated
65 L1ME3E 3 * 99.0 Highly correlated
66 L1ME3G 3 n.s 99.0 Highly correlated
67 L1MEg1 3 **** 99.0 Highly correlated
68 LTR10F 3 **** 28.9 Weakly correlated
69 MER21B 3 * 99.0 Highly correlated
70 MLT1A0 3 n.s 99.0 Highly correlated
71 MLT1L 3 n.s 99.0 Highly correlated
72 AluSx3 2 n.s 74.0 Weakly correlated
73 AluYa8 2 **** 15.2 Weakly correlated
74 ERV3-16A3_I-int 2 n.s 99.0 Highly correlated
75 HAL1ME 2 n.s 99.0 Highly correlated
76 HERVIP10FH-int 2 ** 28.9 Weakly correlated
77 L1HS 2 n.s 8.6 Weakly correlated
78 L1M4b 2 n.s 99.0 Highly correlated
79 L1M6 2 n.s 99.0 Highly correlated
80 L1MA3 2 n.s 74.0 Weakly correlated
81 L1MA9 2 n.s 99.0 Highly correlated
82 L1MB1 2 n.s 99.0 Highly correlated
83 L1MB3 2 n.s 99.0 Highly correlated
84 L1MC1 2 n.s 99.0 Highly correlated
85 L1MC4a 2 n.s 99.0 Highly correlated
86 L1MD3 2 n.s 99.0 Highly correlated
87 L1ME4c 2 n.s 99.0 Highly correlated
88 L1MEj 2 * 99.0 Highly correlated
89 L1PA13 2 n.s 74.0 Weakly correlated
90 L1PA2 2 n.s 15.2 Weakly correlated
91 L1PA5 2 n.s 19.6 Weakly correlated
92 L1PA7 2 n.s 74.0 Weakly correlated
93 L3 2 n.s 99.0 Highly correlated
94 LTR33 2 n.s 99.0 Highly correlated
95 LTR50 2 * 99.0 Highly correlated
96 LTR75B 2 **** 99.0 Highly correlated
97 MLT1B 2 n.s 99.0 Highly correlated
98 MLT1E3 2 * 99.0 Highly correlated
99 MLT1I 2 n.s 99.0 Highly correlated
100 Alu 1 * 74.0 Weakly correlated
101 AluSg4 1 n.s 74.0 Weakly correlated
102 AluYf1 1 n.s 19.6 Weakly correlated
103 AluYi6 1 ** 15.2 Weakly correlated
104 FLAM_A 1 n.s 74.0 Weakly correlated
105 HAL1b 1 n.s 99.0 Highly correlated
106 HERV17-int 1 n.s 28.9 Weakly correlated
107 L1M2 1 n.s 99.0 Highly correlated
108 L1M3 1 n.s 99.0 Highly correlated
109 L1MA2 1 n.s 74.0 Weakly correlated
110 L1MA8 1 n.s 87.0 Weakly correlated
111 L1MB4 1 n.s 99.0 Highly correlated
112 L1MC 1 n.s 99.0 Highly correlated
113 L1MC5a 1 n.s 99.0 Highly correlated
114 L1ME3Cz 1 n.s 99.0 Highly correlated
115 L1ME4b 1 n.s 99.0 Highly correlated
116 L1MEh 1 n.s 99.0 Highly correlated
117 L1P4 1 n.s 74.0 Weakly correlated
118 L1P4d 1 ** 74.0 Weakly correlated
119 L1PA12 1 n.s 74.0 Weakly correlated
120 L1PA14 1 n.s 74.0 Weakly correlated
121 L1PA15 1 n.s 74.0 Weakly correlated
122 L1PA17 1 n.s 74.0 Weakly correlated
123 L1PA4 1 n.s 19.6 Weakly correlated
124 L1PA8 1 n.s 74.0 Weakly correlated
125 L1PB1 1 n.s 74.0 Weakly correlated
126 L1PB3 1 n.s 74.0 Weakly correlated
127 L1PB4 1 n.s 99.0 Highly correlated
128 L1PBa 1 n.s 74.0 Weakly correlated
129 L2-3_Crp 1 * 431.0 Weakly correlated
130 LFSINE_Vert 1 * 319.0 Weakly correlated
131 LTR10B1 1 *** 28.9 Weakly correlated
132 LTR10C 1 * 28.9 Weakly correlated
133 LTR10D 1 ** 28.9 Weakly correlated
134 LTR13 1 * 19.6 Weakly correlated
135 LTR14 1 *** 28.9 Weakly correlated
136 LTR16B 1 * 99.0 Highly correlated
137 LTR16C 1 n.s 99.0 Highly correlated
138 LTR26 1 * 74.0 Weakly correlated
139 LTR33A_ 1 * 99.0 Highly correlated
140 LTR40a 1 n.s 99.0 Highly correlated
141 LTR41 1 * 99.0 Highly correlated
142 LTR41B 1 * 99.0 Highly correlated
143 LTR51 1 ** 74.0 Weakly correlated
144 LTR78 1 n.s 99.0 Highly correlated
145 LTR87 1 * 99.0 Highly correlated
146 LTR9 1 * 43.0 Weakly correlated
147 MER110A 1 ** 99.0 Highly correlated
148 MER11A 1 n.s 28.9 Weakly correlated
149 MER4-int 1 n.s 74.0 Weakly correlated
150 MER4D0 1 ** 74.0 Weakly correlated
151 MER50-int 1 * 43.0 Weakly correlated
152 MER57A-int 1 n.s 43.0 Weakly correlated
153 MER57E1 1 ** 87.0 Weakly correlated
154 MER57E3 1 *** 74.0 Weakly correlated
155 MER61-int 1 n.s 43.0 Weakly correlated
156 MER66-int 1 n.s 43.0 Weakly correlated
157 MER67D 1 * 99.0 Highly correlated
158 MIR1_Amn 1 n.s 319.0 Weakly correlated
159 MLT1E2 1 n.s 99.0 Highly correlated
160 MLT1F2 1 n.s 99.0 Highly correlated
161 MLT1G1 1 n.s 99.0 Highly correlated
162 MLT1J1 1 n.s 99.0 Highly correlated
163 MLT1M 1 * 99.0 Highly correlated
164 MLT1O 1 n.s 99.0 Highly correlated
165 MLT2B4 1 n.s 99.0 Highly correlated
166 MSTB 1 n.s 43.0 Weakly correlated
167 MSTB2 1 n.s 74.0 Weakly correlated
168 MSTD 1 n.s 74.0 Weakly correlated
169 MamRep605 1 n.s 99.0 Highly correlated
170 SVA_A 1 * 19.6 Weakly correlated
171 SVA_B 1 n.s 15.2 Weakly correlated
172 THE1C-int 1 n.s 43.0 Weakly correlated
173 THE1D 1 n.s 43.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1MEd 2 n.s 99.0 Highly correlated
2 ERV3-16A3_I-int 2 n.s 99.0 Highly correlated
3 SVA_A 1 * 19.6 Weakly correlated
4 L1MEg 1 n.s 99.0 Highly correlated
5 FLAM_C 1 n.s 74.0 Weakly correlated
6 MamRep605 1 n.s 99.0 Highly correlated
7 LTR75B 1 *** 99.0 Highly correlated
8 L3b 1 n.s 99.0 Highly correlated
9 L1M2 1 n.s 99.0 Highly correlated
10 L2a 1 n.s 99.0 Highly correlated
11 MLT1M 1 * 99.0 Highly correlated
12 SVA_B 1 n.s 15.2 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP