ZRdb KZFP & Repeats
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Human_ZFP14

  • Protein
    Zinc finger protein 14 homolog
  • Length
    533
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    99.0 Mya
  • Uniprot_ID
    Q9HCL3
  • NCBI_ID
    57677
Sequence:
MAHGSVTFRDVAIDFSQEEWEFLDPAQRDLYRDVMWENYSNFISLGPSISKPDVITLLDEERKEPGMVVREGTRRYCPDLESRYRTNTLSPEKDIYEIYSFQWDIMERIKSYSLQGSIFRNDWECKSKIEGEKEQQEGYFGQVKITSEKMTTYKRHNFLTEYQIVHNGEKVYECKECRKTFIRRSTLSQHLRIHTGEKPYKCKECGQAFRQRAHLIRHHKLHTGEKPYECKECGKAFTVLQELTQHQRLHTGEKPYECKECGKAFRVHQQLARHQRIHTGEKPYECKDCGKTFRQCTHLTRHQRLHTAEKLYECKECGKAFVCGPDLRVHQKIHFGEKPYECKECGKAFRICQQLTVHQSIHTGEKPYECKECGKTFRLRQQLVRHQRIHTREKPYECMECWKTFSSYSQLISHQSIHIGERPYECEECGKAFRLLSQLTQHQSIHTGEKPYECKECRKPFRLLSQLTQHQSIHTGEKPYECKECGKAFRLYSFLTQHQRIHTGEKPYKCKECKKAFRQHSHLTQHQKIHNGI
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 6..78
2 C2h2 172..194
3 C2h2 200..222
4 C2h2 228..250
5 C2h2 256..278
6 C2h2 284..306
7 C2h2 312..334
8 C2h2 340..362
9 C2h2 368..390
10 C2h2 396..418
11 C2h2 424..446
12 C2h2 452..474
13 C2h2 480..502
14 C2h2 508..530
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleus
2 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
3 Molecular Function metal ion binding
4 Molecular Function RNA polymerase II cis-regulatory region sequence-specific DNA binding
5 Biological Process blastocyst hatching
6 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1ME1 32 **** 99.0 Highly correlated
2 L2a 17 n.s 99.0 Highly correlated
3 L2b 13 ** 99.0 Highly correlated
4 L1M5 12 ** 99.0 Highly correlated
5 L2 12 ** 99.0 Highly correlated
6 L2c 12 n.s 99.0 Highly correlated
7 AluSp 9 * 74.0 Weakly correlated
8 AluY 9 n.s 74.0 Weakly correlated
9 L1MC1 9 *** 99.0 Highly correlated
10 AluJb 8 n.s 74.0 Weakly correlated
11 AluSx 8 n.s 74.0 Weakly correlated
12 L1MB3 8 *** 99.0 Highly correlated
13 L1ME2 8 *** 99.0 Highly correlated
14 L1ME3 8 **** 99.0 Highly correlated
15 LTR1A2 8 **** 43.0 Weakly correlated
16 AluSx1 7 n.s 74.0 Weakly correlated
17 L1ME3A 7 *** 99.0 Highly correlated
18 AluJo 6 n.s 74.0 Weakly correlated
19 AluSz 6 n.s 74.0 Weakly correlated
20 L1ME2z 6 **** 99.0 Highly correlated
21 L1MB7 4 n.s 99.0 Highly correlated
22 MIR 4 n.s 99.0 Highly correlated
23 MLT1D 4 n.s 99.0 Highly correlated
24 AluSq2 3 n.s 74.0 Weakly correlated
25 AluSz6 3 n.s 74.0 Weakly correlated
26 L1MC 3 ** 99.0 Highly correlated
27 L1MC5a 3 n.s 99.0 Highly correlated
28 L1MEb 3 **** 99.0 Highly correlated
29 L1MEf 3 n.s 99.0 Highly correlated
30 LTR10A 3 **** 28.9 Weakly correlated
31 MER31A 3 **** 87.0 Weakly correlated
32 MIRc 3 n.s 99.0 Highly correlated
33 AluJr 2 n.s 74.0 Weakly correlated
34 AluSc8 2 n.s 74.0 Weakly correlated
35 AluSx3 2 n.s 74.0 Weakly correlated
36 FLAM_C 2 n.s 74.0 Weakly correlated
37 HAL1 2 n.s 99.0 Highly correlated
38 L1M4 2 n.s 99.0 Highly correlated
39 L1MB8 2 n.s 99.0 Highly correlated
40 L1MC3 2 n.s 99.0 Highly correlated
41 L1MC4a 2 n.s 99.0 Highly correlated
42 L1MEc 2 n.s 99.0 Highly correlated
43 L1PA2 2 n.s 15.2 Weakly correlated
44 L3 2 n.s 99.0 Highly correlated
45 LTR28B 2 **** 43.0 Weakly correlated
46 MER50 2 ** 43.0 Weakly correlated
47 MER52D 2 ** 74.0 Weakly correlated
48 MER61B 2 **** 43.0 Weakly correlated
49 MIR3 2 n.s 99.0 Highly correlated
50 MIRb 2 n.s 99.0 Highly correlated
51 MLT2B1 2 * 99.0 Highly correlated
52 Alu 1 ** 74.0 Weakly correlated
53 AluSc 1 n.s 74.0 Weakly correlated
54 AluSc5 1 n.s 74.0 Weakly correlated
55 AluSg 1 n.s 74.0 Weakly correlated
56 AluSq 1 n.s 74.0 Weakly correlated
57 AluYa5 1 n.s 15.2 Weakly correlated
58 AluYm1 1 n.s 19.6 Weakly correlated
59 ERV24_Prim-int 1 ** 74.0 Weakly correlated
60 FRAM 1 * 74.0 Weakly correlated
61 HERVH-int 1 n.s 28.9 Weakly correlated
62 HERVK-int 1 * 28.9 Weakly correlated
63 HERVS71-int 1 ** 28.9 Weakly correlated
64 L1M1 1 n.s 74.0 Weakly correlated
65 L1M3 1 n.s 99.0 Highly correlated
66 L1M3e 1 * 99.0 Highly correlated
67 L1M4a1 1 n.s 99.0 Highly correlated
68 L1M4b 1 n.s 99.0 Highly correlated
69 L1MB2 1 n.s 99.0 Highly correlated
70 L1MB4 1 n.s 99.0 Highly correlated
71 L1MB5 1 n.s 99.0 Highly correlated
72 L1MC2 1 n.s 99.0 Highly correlated
73 L1MD 1 n.s 99.0 Highly correlated
74 L1MD1 1 n.s 99.0 Highly correlated
75 L1MD2 1 n.s 99.0 Highly correlated
76 L1MDa 1 n.s 99.0 Highly correlated
77 L1ME3B 1 n.s 99.0 Highly correlated
78 L1ME4b 1 n.s 99.0 Highly correlated
79 L1MEg 1 n.s 99.0 Highly correlated
80 L1MEi 1 n.s 99.0 Highly correlated
81 L1P1 1 n.s 19.6 Weakly correlated
82 L1PA5 1 n.s 19.6 Weakly correlated
83 L1PB1 1 n.s 74.0 Weakly correlated
84 L2-3_Crp 1 ** 431.0 Weakly correlated
85 LFSINE_Vert 1 ** 319.0 Weakly correlated
86 LTR12C 1 n.s 19.6 Weakly correlated
87 LTR13 1 ** 19.6 Weakly correlated
88 LTR14B 1 ** 28.9 Weakly correlated
89 LTR16A1 1 * 99.0 Highly correlated
90 LTR16E1 1 * 99.0 Highly correlated
91 LTR33A_ 1 * 99.0 Highly correlated
92 LTR33B 1 ** 99.0 Highly correlated
93 LTR40c 1 ** 99.0 Highly correlated
94 LTR56 1 ** 74.0 Weakly correlated
95 LTR78 1 n.s 99.0 Highly correlated
96 MER21C 1 n.s 99.0 Highly correlated
97 MER34 1 ** 87.0 Weakly correlated
98 MER34C2 1 ** 74.0 Weakly correlated
99 MER39B 1 ** 74.0 Weakly correlated
100 MER51B 1 ** 43.0 Weakly correlated
101 MER52A 1 n.s 74.0 Weakly correlated
102 MER57-int 1 * 87.0 Weakly correlated
103 MER61A 1 ** 43.0 Weakly correlated
104 MER61D 1 *** 43.0 Weakly correlated
105 MER83A-int 1 *** 99.0 Highly correlated
106 MIR1_Amn 1 n.s 319.0 Weakly correlated
107 MLT1A 1 n.s 99.0 Highly correlated
108 MLT1C 1 n.s 94.0 Weakly correlated
109 MLT1F 1 n.s 99.0 Highly correlated
110 MLT1F1 1 * 99.0 Highly correlated
111 MLT1J1 1 * 99.0 Highly correlated
112 MLT1J2 1 n.s 99.0 Highly correlated
113 MLT1M 1 ** 99.0 Highly correlated
114 MLT2C2 1 ** 99.0 Highly correlated
115 MSTA 1 n.s 43.0 Weakly correlated
116 MSTA-int 1 n.s 43.0 Weakly correlated
117 MSTB 1 n.s 43.0 Weakly correlated
118 SVA_C 1 ** 15.2 Weakly correlated
119 THE1C-int 1 n.s 43.0 Weakly correlated
120 THE1D-int 1 n.s 28.9 Weakly correlated
121 X7C_LINE 1 *** 319.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 L1ME1 27 **** 99.0 Highly correlated
2 L1M5 11 ** 99.0 Highly correlated
3 L1MC1 9 *** 99.0 Highly correlated
4 L2a 9 n.s 99.0 Highly correlated
5 L2 9 * 99.0 Highly correlated
6 L1ME3 8 **** 99.0 Highly correlated
7 L1ME2 7 *** 99.0 Highly correlated
8 L2b 7 n.s 99.0 Highly correlated
9 L1MB3 7 ** 99.0 Highly correlated
10 L1ME3A 7 *** 99.0 Highly correlated
11 LTR1A2 5 **** 43.0 Weakly correlated
12 L1ME2z 5 *** 99.0 Highly correlated
13 MLT1D 3 n.s 99.0 Highly correlated
14 L1MC 3 ** 99.0 Highly correlated
15 L1MB7 3 n.s 99.0 Highly correlated
16 L1MEf 3 n.s 99.0 Highly correlated
17 L2c 3 n.s 99.0 Highly correlated
18 MIR3 2 n.s 99.0 Highly correlated
19 LTR28B 2 **** 43.0 Weakly correlated
20 MER52D 2 ** 74.0 Weakly correlated
21 AluSz6 2 n.s 74.0 Weakly correlated
22 MLT2B1 2 * 99.0 Highly correlated
23 L1MC4a 2 n.s 99.0 Highly correlated
24 L1MC3 2 n.s 99.0 Highly correlated
25 L1MB8 2 n.s 99.0 Highly correlated
26 HAL1 2 n.s 99.0 Highly correlated
27 L1M4 2 n.s 99.0 Highly correlated
28 MER52A 1 n.s 74.0 Weakly correlated
29 MSTB 1 n.s 43.0 Weakly correlated
30 MER57-int 1 * 87.0 Weakly correlated
31 MER61A 1 ** 43.0 Weakly correlated
32 MER61B 1 *** 43.0 Weakly correlated
33 MER61D 1 *** 43.0 Weakly correlated
34 MER83A-int 1 *** 99.0 Highly correlated
35 MIR1_Amn 1 n.s 319.0 Weakly correlated
36 L1PA2 1 n.s 15.2 Weakly correlated
37 L1M4b 1 n.s 99.0 Highly correlated
38 AluSc5 1 n.s 74.0 Weakly correlated
39 AluSp 1 n.s 74.0 Weakly correlated
40 AluSx 1 n.s 74.0 Weakly correlated
41 MIRb 1 n.s 99.0 Highly correlated
42 MER31A 1 ** 87.0 Weakly correlated
43 MIRc 1 n.s 99.0 Highly correlated
44 MLT1C 1 n.s 94.0 Weakly correlated
45 X7C_LINE 1 *** 319.0 Weakly correlated
46 THE1D-int 1 n.s 28.9 Weakly correlated
47 MLT2C2 1 ** 99.0 Highly correlated
48 MLT1J1 1 * 99.0 Highly correlated
49 MLT1J2 1 n.s 99.0 Highly correlated
50 L1MD2 1 n.s 99.0 Highly correlated
51 ERV24_Prim-int 1 ** 74.0 Weakly correlated
52 HERVK-int 1 * 28.9 Weakly correlated
53 HERVS71-int 1 ** 28.9 Weakly correlated
54 L1M3 1 n.s 99.0 Highly correlated
55 L1M3e 1 * 99.0 Highly correlated
56 L1MB2 1 n.s 99.0 Highly correlated
57 L1MB4 1 n.s 99.0 Highly correlated
58 L1MB5 1 n.s 99.0 Highly correlated
59 L1MC2 1 n.s 99.0 Highly correlated
60 L1MC5a 1 n.s 99.0 Highly correlated
61 L1MD 1 n.s 99.0 Highly correlated
62 L1MD1 1 n.s 99.0 Highly correlated
63 MER50 1 n.s 43.0 Weakly correlated
64 L1MDa 1 n.s 99.0 Highly correlated
65 L1ME3B 1 n.s 99.0 Highly correlated
66 L1MEb 1 * 99.0 Highly correlated
67 L1MEi 1 n.s 99.0 Highly correlated
68 LTR16E1 1 * 99.0 Highly correlated
69 LTR33A_ 1 * 99.0 Highly correlated
70 LTR33B 1 ** 99.0 Highly correlated
71 LTR40c 1 ** 99.0 Highly correlated
72 LTR56 1 ** 74.0 Weakly correlated
73 LTR78 1 n.s 99.0 Highly correlated
74 MER21C 1 n.s 99.0 Highly correlated
75 MER34 1 ** 87.0 Weakly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP
1 L1MB3 99.0 Highly correlated
2 L1MC1 99.0 Highly correlated
3 L1ME1 99.0 Highly correlated
4 L1ME2 99.0 Highly correlated
5 L1ME3 99.0 Highly correlated
6 L1ME3A 99.0 Highly correlated