ZRdb KZFP & Repeats
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Human_RBAK

  • Protein
    RB-associated KRAB zinc finger protein
  • Length
    714
  • Organism
    Homo sapiens (Human)
  • Time of emergence
    99.0 Mya
  • Time of Changing in binding specificity
    99.0 Mya
  • Uniprot_ID
    Q9NYW8
  • NCBI_ID
    57786
Sequence:
MNTLQGPVSFKDVAVDFTQEEWQQLDPDEKITYRDVMLENYSHLVSVGYDTTKPNVIIKLEQGEEPWIMGGEFPCQHSPEAWRVDDLIERIQENEDKHSRQAACINSKTLTEEKENTFSQIYMETSLVPSSIIAHNCVSCGKNLESISQLISSDGSYARTKPDECNECGKTYHGEKMCEFNQNGDTYSHNEENILQKISILEKPFEYNECMEALDNEAVFIAHKRAYIGEKPYEWNDSGPDFIQMSNFNAYQRSQMEMKPFECSECGKSFCKKSKFIIHQRAHTGEKPYECNVCGKSFSQKGTLTVHRRSHLEEKPYKCNECGKTFCQKLHLTQHLRTHSGEKPYECSECGKTFCQKTHLTLHQRNHSGERPYPCNECGKSFSRKSALSDHQRTHTGEKLYKCNECGKSYYRKSTLITHQRTHTGEKPYQCSECGKFFSRVSYLTIHYRSHLEEKPYECNECGKTFNLNSAFIRHRKVHTEEKSHECSECGKFSQLYLTDHHTAHLEEKPYECNECGKTFLVNSAFDGHQPLPKGEKSYECNVCGKLFNELSYYTEHYRSHSEEKPYGCSECGKTFSHNSSLFRHQRVHTGEKPYECYECGKFFSQKSYLTIHHRIHSGEKPYECSKCGKVFSRMSNLTVHYRSHSGEKPYECNECGKVFSQKSYLTVHYRTHSGEKPYECNECGKKFHHRSAFNSHQRIHRRGNMNVLDVENL
Domain KRAB, ZF, and degenerated ZF domains of KZFPs. :
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# Domain name Pos
1 KRAB 8..79
2 C2h2 261..283
3 C2h2 289..311
4 C2h2 317..339
5 C2h2 345..367
6 C2h2 373..395
7 C2h2 401..423
8 C2h2 429..451
9 C2h2 457..479
10 C2h2 485..505
11 dec2h2 511..533
12 C2h2 539..561
13 C2h2 567..589
14 C2h2 595..617
15 C2h2 623..645
16 C2h2 651..673
17 C2h2 679..701
Gene Ontology Annotation The Gene Ontology (GO) describes knowledge of the biological domain based on three aspects: Molecular function, Biological process, and Cellular component. :
# Type TERM
1 Cellular Component nucleoplasm
2 Cellular Component nucleus
3 Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific
4 Molecular Function RNA polymerase II transcription regulatory region sequence-specific DNA binding
5 Molecular Function zinc ion binding
6 Biological Process negative regulation of DNA-templated transcription
7 Biological Process regulation of DNA-templated transcription
8 Biological Process regulation of transcription by RNA polymerase II
Is there ChIP-seq data Is there any ChIP-seq data available for these KZFPs in the Cistrome database? :
Yes
Motif(meme-ChIP) DNA binding motifs of KZFPs obtained using meme-ChIP and mapped using pylogo. :
Forward:
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Reverse:
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Peak overlapping A ChIP-seq peak of KZFPs that intersects with a certain repeats sequences on the genome. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 MLT1I 13 **** 99.0 Highly correlated
2 AluJb 9 n.s 74.0 Weakly correlated
3 MLT1H 7 **** 99.0 Highly correlated
4 L2a 7 n.s 99.0 Highly correlated
5 MIRc 6 n.s 99.0 Highly correlated
6 AluSx 6 n.s 74.0 Weakly correlated
7 L2c 5 n.s 99.0 Highly correlated
8 MIRb 5 n.s 99.0 Highly correlated
9 MIR 5 n.s 99.0 Highly correlated
10 MLT1J2 4 *** 99.0 Highly correlated
11 L2b 4 n.s 99.0 Highly correlated
12 AluSx1 4 n.s 74.0 Weakly correlated
13 AluY 4 n.s 74.0 Weakly correlated
14 LTR50 3 *** 99.0 Highly correlated
15 L1P1 3 * 19.6 Weakly correlated
16 MIR3 3 n.s 99.0 Highly correlated
17 AluSz 3 n.s 74.0 Weakly correlated
18 L3 3 n.s 99.0 Highly correlated
19 LTR10A 3 **** 28.9 Weakly correlated
20 MIR1_Amn 2 ** 319.0 Weakly correlated
21 L1P4a 2 ** 74.0 Weakly correlated
22 L1PA6 2 n.s 28.9 Weakly correlated
23 MER50 2 ** 43.0 Weakly correlated
24 AluJo 2 n.s 74.0 Weakly correlated
25 MLT1F1 2 ** 99.0 Highly correlated
26 AluSz6 2 n.s 74.0 Weakly correlated
27 AluSp 2 n.s 74.0 Weakly correlated
28 AluSx3 2 n.s 74.0 Weakly correlated
29 MamRTE1 2 * 99.0 Highly correlated
30 AluJr 2 n.s 74.0 Weakly correlated
31 FLAM_C 2 n.s 74.0 Weakly correlated
32 MLT1F2 2 * 99.0 Highly correlated
33 MER39B 1 * 74.0 Weakly correlated
34 MER41G 1 *** 74.0 Weakly correlated
35 X7C_LINE 1 *** 319.0 Weakly correlated
36 MER4D1 1 * 74.0 Weakly correlated
37 LTR88a 1 ** 99.0 Highly correlated
38 UCON51 1 **** 319.0 Weakly correlated
39 LTR75_1 1 **** 99.0 Highly correlated
40 MER50-int 1 ** 43.0 Weakly correlated
41 LTR72 1 *** 74.0 Weakly correlated
42 PABL_B-int 1 ** 74.0 Weakly correlated
43 MamSINE1 1 * 99.0 Highly correlated
44 MER51A 1 ** 43.0 Weakly correlated
45 MER51C 1 *** 43.0 Weakly correlated
46 MER65D 1 *** 87.0 Weakly correlated
47 MER66B 1 * 43.0 Weakly correlated
48 MamGypLTR3a 1 ** 99.0 Highly correlated
49 MSTD 1 n.s 74.0 Weakly correlated
50 MSTB-int 1 * 43.0 Weakly correlated
51 MLT1L 1 n.s 99.0 Highly correlated
52 MLT1G 1 * 99.0 Highly correlated
53 MLT1E3 1 * 99.0 Highly correlated
54 L1M6B 1 *** 99.0 Highly correlated
55 L1ME4b 1 n.s 99.0 Highly correlated
56 L1ME3A 1 n.s 99.0 Highly correlated
57 L1MDb 1 * 99.0 Highly correlated
58 L1MC4 1 n.s 99.0 Highly correlated
59 L1MC3 1 n.s 99.0 Highly correlated
60 L1MB7 1 n.s 99.0 Highly correlated
61 L1MA9 1 n.s 99.0 Highly correlated
62 L1MA10 1 n.s 99.0 Highly correlated
63 L1P2 1 n.s 28.9 Weakly correlated
64 L1M4 1 n.s 99.0 Highly correlated
65 HERVK22-int 1 * 43.0 Weakly correlated
66 AluYh9 1 **** 15.2 Weakly correlated
67 AluSx4 1 n.s 74.0 Weakly correlated
68 AluSq2 1 n.s 74.0 Weakly correlated
69 AluSg 1 n.s 74.0 Weakly correlated
70 AluSc5 1 n.s 74.0 Weakly correlated
71 AluJr4 1 n.s 74.0 Weakly correlated
72 L4_B_Mam 1 * 99.0 Highly correlated
73 LTR37-int 1 * 99.0 Highly correlated
74 LTR33 1 n.s 99.0 Highly correlated
75 LTR22B2 1 **** 28.9 Weakly correlated
76 LTR18A 1 *** 43.0 Weakly correlated
77 LTR16D1 1 *** 99.0 Highly correlated
78 LTR16A1 1 * 99.0 Highly correlated
79 LTR13 1 ** 19.6 Weakly correlated
80 L5 1 ** 99.0 Highly correlated
81 LTR45C 1 ** 99.0 Highly correlated
82 L2 1 n.s 99.0 Highly correlated
83 L1PA5 1 n.s 19.6 Weakly correlated
84 L1PA3 1 n.s 19.6 Weakly correlated
85 L1PA2 1 n.s 15.2 Weakly correlated
86 L1PA17 1 n.s 74.0 Weakly correlated
87 L1PA15 1 n.s 74.0 Weakly correlated
88 L1PA10 1 n.s 74.0 Weakly correlated
Motif in Repeats The motif of KZFPs identified by the MEME-ChIP is present in repeats sequences. :
# Repeats name Record number Significance Emergence time(Mya) Time correlation with KZFP
1 AluYh9 1 **** 15.2 Weakly correlated
2 L2c 1 n.s 99.0 Highly correlated
3 MLT1I 1 n.s 99.0 Highly correlated
4 AluY 1 n.s 74.0 Weakly correlated
5 L1ME4b 1 n.s 99.0 Highly correlated
Motif in Repeats Consensus The motif of KZFPs identified by MEME-ChIP analysis can be utilized to locate the corresponding region within the consensus sequences of repeats. :
# Repeats name Emergence time(Mya) Time correlation with KZFP