Human_PRDM9
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ProteinHistone-lysine N-methyltransferase PRDM9
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Length894
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OrganismHomo sapiens (Human)
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Time of emergence99.0 Mya
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Time of Changing in binding specificity0.0 Mya
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Uniprot_ID
-
NCBI_ID
Sequence:
MSPEKSQEESPEEDTERTERKPMVKDAFKDISIYFTKEEWAEMGDWEKTRYRNVKRNYNALITIGLRATRPAFMCHRRQAIKLQVDDTEDSDEEWTPRQQVKPPWMALRVEQRKHQKGMPKASFSNESSLKELSRTANLLNASGSEQAQKPVSPSGEASTSGQHSRLKLELRKKETERKMYSLRERKGHAYKEVSEPQDDDYLYCEMCQNFFIDSCAAHGPPTFVKDSAVDKGHPNRSALSLPPGLRIGPSGIPQAGLGVWNEASDLPLGLHFGPYEGRITEDEEAANNGYSWLITKGRNCYEYVDGKDKSWANWMRYVNCARDDEEQNLVAFQYHRQIFYRTCRVIRPGCELLVWYGDEYGQELGIKWGSKWKKELMAGREPKPEIHPCPSCCLAFSSQKFLSQHVERNHSSQNFPGPSARKLLQPENPCPGDQNQEQQYPDPHSRNDKTKGQEIKERSKLLNKRTWQREISRAFSSPPKGQMGSCRVGKRIMEEESRTGQKVNPGNTGKLFVGVGISRIAKVKYGECGQGFSVKSDVITHQRTHTGEKLYVCRECGRGFSWKSHLLIHQRIHTGEKPYVCRECGRGFSWQSVLLTHQRTHTGEKPYVCRECGRGFSRQSVLLTHQRRHTGEKPYVCRECGRGFSRQSVLLTHQRRHTGEKPYVCRECGRGFSWQSVLLTHQRTHTGEKPYVCRECGRGFSWQSVLLTHQRTHTGEKPYVCRECGRGFSNKSHLLRHQRTHTGEKPYVCRECGRGFRDKSHLLRHQRTHTGEKPYVCRECGRGFRDKSNLLSHQRTHTGEKPYVCRECGRGFSNKSHLLRHQRTHTGEKPYVCRECGRGFRNKSHLLRHQRTHTGEKPYVCRECGRGFSDRSSLCYHQRTHTGEKPYVCREDE
Domain
:
| # | Domain name | Pos | |
|---|---|---|---|
| 1 | KRAB | 23..86 | |
| 2 | C2h2 | 388..411 | |
| 3 | dec2h2 | 524..546 | |
| 4 | C2h2 | 552..574 | |
| 5 | C2h2 | 580..602 | |
| 6 | C2h2 | 608..630 | |
| 7 | C2h2 | 636..658 | |
| 8 | C2h2 | 664..686 | |
| 9 | C2h2 | 692..714 | |
| 10 | C2h2 | 720..742 | |
| 11 | C2h2 | 748..770 | |
| 12 | C2h2 | 776..798 | |
| 13 | C2h2 | 804..826 | |
| 14 | C2h2 | 832..854 | |
| 15 | C2h2 | 860..882 |
Gene Ontology Annotation
:
| # | Type | TERM | |
|---|---|---|---|
| 1 | Cellular Component | chromosome | |
| 2 | Cellular Component | nucleoplasm | |
| 3 | Cellular Component | nucleus | |
| 4 | Molecular Function | histone methyltransferase activity (H3-K36 specific) | |
| 5 | Molecular Function | histone methyltransferase activity (H3-K4 specific) | |
| 6 | Molecular Function | histone-lysine N-methyltransferase activity | |
| 7 | Molecular Function | metal ion binding | |
| 8 | Molecular Function | protein homodimerization activity | |
| 9 | Molecular Function | recombination hotspot binding | |
| 10 | Molecular Function | transcription cis-regulatory region binding | |
| 11 | Biological Process | chromatin organization | |
| 12 | Biological Process | double-strand break repair involved in meiotic recombination | |
| 13 | Biological Process | female gamete generation | |
| 14 | Biological Process | histone H3-K36 dimethylation | |
| 15 | Biological Process | histone H3-K36 trimethylation | |
| 16 | Biological Process | histone H3-K4 dimethylation | |
| 17 | Biological Process | histone H3-K4 methylation | |
| 18 | Biological Process | histone H3-K4 monomethylation | |
| 19 | Biological Process | histone H3-K4 trimethylation | |
| 20 | Biological Process | histone H3-K9 methylation | |
| 21 | Biological Process | homologous chromosome pairing at meiosis | |
| 22 | Biological Process | male gamete generation | |
| 23 | Biological Process | meiotic gene conversion | |
| 24 | Biological Process | negative regulation of apoptotic process | |
| 25 | Biological Process | positive regulation of fertilization | |
| 26 | Biological Process | positive regulation of histone H3-K36 trimethylation | |
| 27 | Biological Process | positive regulation of histone H3-K4 trimethylation | |
| 28 | Biological Process | positive regulation of reciprocal meiotic recombination | |
| 29 | Biological Process | regulation of DNA-templated transcription | |
| 30 | Biological Process | regulation of gene expression |
Is there ChIP-seq data
:
Yes
Motif(meme-ChIP)
:
Forward:
Reverse:
Peak overlapping
:
| # | Repeats name | Record number | Significance | Emergence time(Mya) | Time correlation with KZFP | |
|---|---|---|---|---|---|---|
| 1 | THE1B | 14 | **** | 43.0 | Weakly correlated | |
| 2 | L2a | 13 | **** | 99.0 | Weakly correlated | |
| 3 | L2c | 6 | ** | 99.0 | Weakly correlated | |
| 4 | MIRb | 5 | * | 99.0 | Weakly correlated | |
| 5 | L2b | 5 | ** | 99.0 | Weakly correlated | |
| 6 | LTR10A | 4 | **** | 28.9 | Weakly correlated | |
| 7 | MSTA | 4 | *** | 43.0 | Weakly correlated | |
| 8 | L2 | 4 | ** | 99.0 | Weakly correlated | |
| 9 | AluY | 4 | n.s | 74.0 | Weakly correlated | |
| 10 | L1MA2 | 3 | ** | 74.0 | Weakly correlated | |
| 11 | L1MEi | 3 | **** | 99.0 | Weakly correlated | |
| 12 | THE1A | 3 | **** | 43.0 | Weakly correlated | |
| 13 | AluJb | 2 | n.s | 74.0 | Weakly correlated | |
| 14 | MIR | 2 | n.s | 99.0 | Weakly correlated | |
| 15 | L1MC5 | 2 | ** | 99.0 | Weakly correlated | |
| 16 | LTR10F | 2 | **** | 28.9 | Weakly correlated | |
| 17 | L1MC1 | 2 | * | 99.0 | Weakly correlated | |
| 18 | MIRc | 2 | n.s | 99.0 | Weakly correlated | |
| 19 | MLT1H2 | 2 | **** | 99.0 | Weakly correlated | |
| 20 | THE1D | 2 | ** | 43.0 | Weakly correlated | |
| 21 | AluJr | 2 | n.s | 74.0 | Weakly correlated | |
| 22 | MLT1K | 2 | ** | 99.0 | Weakly correlated | |
| 23 | AluSg | 2 | n.s | 74.0 | Weakly correlated | |
| 24 | AluSz | 2 | n.s | 74.0 | Weakly correlated | |
| 25 | MER50B | 1 | *** | 43.0 | Weakly correlated | |
| 26 | L1PBa1 | 1 | ** | 74.0 | Weakly correlated | |
| 27 | LTR28C | 1 | *** | 43.0 | Weakly correlated | |
| 28 | THE1B-int | 1 | n.s | 43.0 | Weakly correlated | |
| 29 | THE1A-int | 1 | ** | 43.0 | Weakly correlated | |
| 30 | Mam_R4 | 1 | **** | 99.0 | Weakly correlated | |
| 31 | LTR33 | 1 | * | 99.0 | Weakly correlated | |
| 32 | LTR8B | 1 | ** | 43.0 | Weakly correlated | |
| 33 | MamRTE1 | 1 | ** | 99.0 | Weakly correlated | |
| 34 | MER34A1 | 1 | *** | 99.0 | Weakly correlated | |
| 35 | MLT1J | 1 | * | 99.0 | Weakly correlated | |
| 36 | MER52D | 1 | ** | 74.0 | Weakly correlated | |
| 37 | MER61A | 1 | *** | 43.0 | Weakly correlated | |
| 38 | MER83 | 1 | **** | 43.0 | Weakly correlated | |
| 39 | MamGypsy2-I | 1 | ** | 99.0 | Weakly correlated | |
| 40 | MIR3 | 1 | n.s | 99.0 | Weakly correlated | |
| 41 | MSTA-int | 1 | * | 43.0 | Weakly correlated | |
| 42 | MLT2B3 | 1 | ** | 99.0 | Weakly correlated | |
| 43 | MLT1J2 | 1 | ** | 99.0 | Weakly correlated | |
| 44 | MLT1A0 | 1 | n.s | 99.0 | Weakly correlated | |
| 45 | MLT1D | 1 | n.s | 99.0 | Weakly correlated | |
| 46 | L1MA3 | 1 | n.s | 74.0 | Weakly correlated | |
| 47 | AluJo | 1 | n.s | 74.0 | Weakly correlated | |
| 48 | AluJr4 | 1 | n.s | 74.0 | Weakly correlated | |
| 49 | AluSq10 | 1 | *** | 74.0 | Weakly correlated | |
| 50 | AluSx | 1 | n.s | 74.0 | Weakly correlated | |
| 51 | AluSx1 | 1 | n.s | 74.0 | Weakly correlated | |
| 52 | AluSx3 | 1 | n.s | 74.0 | Weakly correlated | |
| 53 | ERV3-16A3_I-int | 1 | * | 99.0 | Weakly correlated | |
| 54 | ERV3-16A3_LTR | 1 | *** | 99.0 | Weakly correlated | |
| 55 | FLAM_A | 1 | ** | 74.0 | Weakly correlated | |
| 56 | HERV16-int | 1 | ** | 99.0 | Weakly correlated | |
| 57 | L1M4 | 1 | n.s | 99.0 | Weakly correlated | |
| 58 | L1M4b | 1 | * | 99.0 | Weakly correlated | |
| 59 | L1M5 | 1 | n.s | 99.0 | Weakly correlated | |
| 60 | L1MA1 | 1 | * | 74.0 | Weakly correlated | |
| 61 | LTR16A | 1 | ** | 99.0 | Weakly correlated | |
| 62 | L1MA4 | 1 | n.s | 87.0 | Weakly correlated | |
| 63 | L1MA5 | 1 | * | 87.0 | Weakly correlated | |
| 64 | L1MC | 1 | * | 99.0 | Weakly correlated | |
| 65 | L1MC4 | 1 | n.s | 99.0 | Weakly correlated | |
| 66 | L1MC5a | 1 | n.s | 99.0 | Weakly correlated | |
| 67 | L1MCa | 1 | * | 99.0 | Weakly correlated | |
| 68 | L1MCc | 1 | ** | 99.0 | Weakly correlated | |
| 69 | L1MDb | 1 | *** | 99.0 | Weakly correlated | |
| 70 | L1ME1 | 1 | n.s | 99.0 | Weakly correlated | |
| 71 | L1ME3A | 1 | n.s | 99.0 | Weakly correlated | |
| 72 | L1ME4a | 1 | n.s | 99.0 | Weakly correlated | |
| 73 | L1MEj | 1 | ** | 99.0 | Weakly correlated | |
| 74 | L1P4a | 1 | ** | 74.0 | Weakly correlated | |
| 75 | L3 | 1 | n.s | 99.0 | Weakly correlated |
Motif in Repeats
:
| # | Repeats name | Record number | Significance | Emergence time(Mya) | Time correlation with KZFP | |
|---|---|---|---|---|---|---|
| 1 | THE1B | 14 | **** | 43.0 | Weakly correlated | |
| 2 | L2a | 9 | ** | 99.0 | Weakly correlated | |
| 3 | L2b | 4 | * | 99.0 | Weakly correlated | |
| 4 | LTR10A | 3 | **** | 28.9 | Weakly correlated | |
| 5 | MSTA | 3 | ** | 43.0 | Weakly correlated | |
| 6 | THE1D | 2 | ** | 43.0 | Weakly correlated | |
| 7 | LTR10F | 2 | **** | 28.9 | Weakly correlated | |
| 8 | L2 | 2 | n.s | 99.0 | Weakly correlated | |
| 9 | THE1A | 2 | *** | 43.0 | Weakly correlated | |
| 10 | MLT1A0 | 1 | n.s | 99.0 | Weakly correlated | |
| 11 | MIRb | 1 | n.s | 99.0 | Weakly correlated | |
| 12 | MER50B | 1 | *** | 43.0 | Weakly correlated | |
| 13 | LTR8B | 1 | ** | 43.0 | Weakly correlated | |
| 14 | LTR33 | 1 | * | 99.0 | Weakly correlated | |
| 15 | MLT1J | 1 | * | 99.0 | Weakly correlated | |
| 16 | MLT1K | 1 | * | 99.0 | Weakly correlated | |
| 17 | MLT2B3 | 1 | ** | 99.0 | Weakly correlated | |
| 18 | LTR28C | 1 | *** | 43.0 | Weakly correlated | |
| 19 | L2c | 1 | n.s | 99.0 | Weakly correlated | |
| 20 | L3 | 1 | n.s | 99.0 | Weakly correlated | |
| 21 | AluSq10 | 1 | *** | 74.0 | Weakly correlated | |
| 22 | L1P4a | 1 | ** | 74.0 | Weakly correlated | |
| 23 | L1MCa | 1 | * | 99.0 | Weakly correlated | |
| 24 | L1MC1 | 1 | n.s | 99.0 | Weakly correlated | |
| 25 | L1MC | 1 | * | 99.0 | Weakly correlated | |
| 26 | L1MA3 | 1 | n.s | 74.0 | Weakly correlated | |
| 27 | L1MA1 | 1 | * | 74.0 | Weakly correlated | |
| 28 | L1M4b | 1 | * | 99.0 | Weakly correlated | |
| 29 | HERV16-int | 1 | ** | 99.0 | Weakly correlated | |
| 30 | AluY | 1 | n.s | 74.0 | Weakly correlated | |
| 31 | AluSz | 1 | n.s | 74.0 | Weakly correlated | |
| 32 | AluSx3 | 1 | n.s | 74.0 | Weakly correlated | |
| 33 | AluSx1 | 1 | n.s | 74.0 | Weakly correlated |
Motif in Repeats Consensus
:
| # | Repeats name | Emergence time(Mya) | Time correlation with KZFP |
|---|